Title:
BIOLOGICAL VESICLE SURFACE BIOMARKER DETECTION DEVICE
Document Type and Number:
WIPO Patent Application WO/2021/220928
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a system, device, and method for quantitatively analyzing, from among test targets resulting from a liquid biopsy, an expression amount of target marker molecules such as a protein present on a surface, by detecting and measuring biological vesicles, having a size of 20 microns or less and including cells, exosomes, and extracellular vesicles, from among body fluid-derived samples. By capturing, on a support, a body fluid-derived sample containing the plurality of target marker molecules, and by detecting and measuring the plurality of target marker molecules via a distinguishing substance such as an antibody, it became clear that it is possible to provide a method for qualitatively and quantitatively analyzing the expression of the plurality of target marker molecules, and a device and system therefor.
Inventors:
MIYAHARA YUJI (JP)
TABATA MIYUKI (JP)
TABATA MIYUKI (JP)
Application Number:
PCT/JP2021/016271
Publication Date:
November 04, 2021
Filing Date:
April 22, 2021
Export Citation:
Assignee:
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
International Classes:
G01N33/53; G01N33/543
Domestic Patent References:
| WO2015029979A1 | 2015-03-05 | |||
| WO2017200070A1 | 2017-11-23 | |||
| WO2017126617A1 | 2017-07-27 |
Foreign References:
| JP2018530755A | 2018-10-18 | |||
| US20170227533A1 | 2017-08-10 | |||
| JP2013246060A | 2013-12-09 |
Other References:
BIOSENSORS AND BIOELECTRONICS, vol. 117, 2018, pages 175 - 182
See also references of EP 4145130A1
See also references of EP 4145130A1
Attorney, Agent or Firm:
UCHIYAMA Tsutomu et al. (JP)
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