Title:
BIOMARKER COMPOSITION FOR PREDICTING PROGNOSIS OF BRAIN DISEASE CAUSED BY MICROPLASTIC EXPOSURE AND METHOD FOR PREDICTING PROGNOSIS USING SAME
Document Type and Number:
WIPO Patent Application WO/2022/010202
Kind Code:
A1
Abstract:
The present invention relates to: a biomarker composition for predicting the prognosis of brain disease caused by microplastic exposure; and a use thereof. More particularly, it was confirmed that polyethylene microspheres (PS) in a mouse animal model orally administered with the PS penetrate brain tissue to change the level of metabolites inside the brain tissue and the diversity of intestinal microorganisms, thereby causing brain disease, and thus the present invention is intended to provide a biomarker composition for predicting the prognosis of brain disease caused by microplastic exposure, and a method for predicting the prognosis of brain disease using same.
Inventors:
KIM JIN SU (KR)
KIM HYEONGI (KR)
ZAHEER JAVERIA (KR)
LEE YONG JIN (KR)
KANG KYUNG JUN (KR)
KO IN OK (KR)
KIM HYEONGI (KR)
ZAHEER JAVERIA (KR)
LEE YONG JIN (KR)
KANG KYUNG JUN (KR)
KO IN OK (KR)
Application Number:
PCT/KR2021/008493
Publication Date:
January 13, 2022
Filing Date:
July 05, 2021
Export Citation:
Assignee:
KOREA INST RADIOLOGICAL & MEDICAL SCIENCES (KR)
International Classes:
C12Q1/6883; C12Q1/6869; G16C20/10; G16C20/30
Other References:
JAVUREK ANGELA B., SPOLLEN WILLIAM G., JOHNSON SARAH A., BIVENS NATHAN J., BROMERT KAREN H., GIVAN SCOTT A., ROSENFELD CHERYL S.: "Effects of exposure to bisphenol A and ethinyl estradiol on the gut microbiota of parents and their offspring in a rodent model", GUT MICROBES, LANDES BIOSCIENCE, UNITED STATES, vol. 7, no. 6, 1 November 2016 (2016-11-01), United States , pages 471 - 485, XP055886352, ISSN: 1949-0976, DOI: 10.1080/19490976.2016.1234657
STEIN T. PETER, SCHLUTER MARGARET D., STEER ROBERT A., GUO LINING, MING XUE: "Bisphenol A Exposure in Children With Autism Spectrum Disorders : Bisphenol A and autism", AUTISM RESEARCH, vol. 8, no. 3, 1 June 2015 (2015-06-01), pages 272 - 283, XP055886353, ISSN: 1939-3792, DOI: 10.1002/aur.1444
XUE MING, STEIN T. PETER, BARNES VIRGINIA, RHODES NELSON, GUO LINING: "Metabolic Perturbance in Autism Spectrum Disorders: A Metabolomics Study", JOURNAL OF PROTEOME RESEARCH, AMERICAN CHEMICAL SOCIETY, vol. 11, no. 12, pages 5856 - 5862, XP055321133, ISSN: 1535-3893, DOI: 10.1021/pr300910n
LUTKENHOFF E S, VAN ERP T G, THOMAS M A, THERMAN S, MANNINEN M, HUTTUNEN M O, KAPRIO J, LÖNNQVIST J, O'NEILL J, CANNON T D: "Proton MRS in twin pairs discordant for schizophrenia", MOLECULAR PSYCHIATRY, NATURE PUBLISHING GROUP UK, LONDON, vol. 15, no. 3, 1 March 2010 (2010-03-01), London, pages 308 - 318, XP055886354, ISSN: 1359-4184, DOI: 10.1038/mp.2008.87
JIN YUANXIANG, LIANG LU, WENQING TU, TING LUO, ZHENGWEI FU : "Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice", SCIENCE OF THE TOTAL ENVIRONMENT, vol. 649, 28 August 2018 (2018-08-28), pages 308 - 317, XP055886356, DOI: 10.1016/j.scitotenv.2018.08.353
PRÜST MINNE, MEIJER JONELLE, WESTERINK REMCO H. S.: "The plastic brain: neurotoxicity of micro- and nanoplastics", PARTICLE AND FIBRE TOXICOLOGY, vol. 17, no. 1, 1 December 2020 (2020-12-01), XP055886357, DOI: 10.1186/s12989-020-00358-y
DE THEIJE CAROLINE G.M., HARM WOPEREIS, MOHAMED RAMADAN, TIEMEN VAN EIJNDTHOVEN, JOLANDA LAMBERT, JAN KNOL, JOHAN GARSSEN, ALETTA : "Altered gut microbiota and activity in a murine model of autism spectrum disorders", BRAIN, BEHAVIOR, AND IMMUNITY, vol. 37, 11 December 2013 (2013-12-11), pages 197 - 206, XP055886360, DOI: 10.1016/j.bbi.2013.12.005
ROSENFELD CHERYL S: "Microbiome Disturbances and Autism Spectrum Disorders", DRUG METABOLISM AND DISPOSITION, vol. 43, no. 10, 1 January 2015 (2015-01-01), US , pages 1557 - 1571, XP009533191, ISSN: 0090-9556, DOI: 10.1124/dmd.115.063826
SHARMA, A. ET AL., WORLD J NUCL MED, vol. 17, no. 2, 2018, pages 94 - 101
KAIDANOVICH-BEILIN, O. ET AL.: "Assessment of social interaction behaviors", J VIS EXP, 2011, pages 48
ROULLET, F.I.J.N. CRAWLEY: "Mouse models of autism: testing hypotheses about molecular mechanisms", CURR TOP BEHAV NEUROSCI, vol. 7, 2011, pages 187 - 212
ANGOA-PEREZ, M. ET AL.: "Marble burying and nestlet shredding as tests of repetitive, compulsive-like behaviors in mice", J VIS EXP, no. 82, 2013, pages 50978
STEIN T. PETER, SCHLUTER MARGARET D., STEER ROBERT A., GUO LINING, MING XUE: "Bisphenol A Exposure in Children With Autism Spectrum Disorders : Bisphenol A and autism", AUTISM RESEARCH, vol. 8, no. 3, 1 June 2015 (2015-06-01), pages 272 - 283, XP055886353, ISSN: 1939-3792, DOI: 10.1002/aur.1444
XUE MING, STEIN T. PETER, BARNES VIRGINIA, RHODES NELSON, GUO LINING: "Metabolic Perturbance in Autism Spectrum Disorders: A Metabolomics Study", JOURNAL OF PROTEOME RESEARCH, AMERICAN CHEMICAL SOCIETY, vol. 11, no. 12, pages 5856 - 5862, XP055321133, ISSN: 1535-3893, DOI: 10.1021/pr300910n
LUTKENHOFF E S, VAN ERP T G, THOMAS M A, THERMAN S, MANNINEN M, HUTTUNEN M O, KAPRIO J, LÖNNQVIST J, O'NEILL J, CANNON T D: "Proton MRS in twin pairs discordant for schizophrenia", MOLECULAR PSYCHIATRY, NATURE PUBLISHING GROUP UK, LONDON, vol. 15, no. 3, 1 March 2010 (2010-03-01), London, pages 308 - 318, XP055886354, ISSN: 1359-4184, DOI: 10.1038/mp.2008.87
JIN YUANXIANG, LIANG LU, WENQING TU, TING LUO, ZHENGWEI FU : "Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice", SCIENCE OF THE TOTAL ENVIRONMENT, vol. 649, 28 August 2018 (2018-08-28), pages 308 - 317, XP055886356, DOI: 10.1016/j.scitotenv.2018.08.353
PRÜST MINNE, MEIJER JONELLE, WESTERINK REMCO H. S.: "The plastic brain: neurotoxicity of micro- and nanoplastics", PARTICLE AND FIBRE TOXICOLOGY, vol. 17, no. 1, 1 December 2020 (2020-12-01), XP055886357, DOI: 10.1186/s12989-020-00358-y
DE THEIJE CAROLINE G.M., HARM WOPEREIS, MOHAMED RAMADAN, TIEMEN VAN EIJNDTHOVEN, JOLANDA LAMBERT, JAN KNOL, JOHAN GARSSEN, ALETTA : "Altered gut microbiota and activity in a murine model of autism spectrum disorders", BRAIN, BEHAVIOR, AND IMMUNITY, vol. 37, 11 December 2013 (2013-12-11), pages 197 - 206, XP055886360, DOI: 10.1016/j.bbi.2013.12.005
ROSENFELD CHERYL S: "Microbiome Disturbances and Autism Spectrum Disorders", DRUG METABOLISM AND DISPOSITION, vol. 43, no. 10, 1 January 2015 (2015-01-01), US , pages 1557 - 1571, XP009533191, ISSN: 0090-9556, DOI: 10.1124/dmd.115.063826
SHARMA, A. ET AL., WORLD J NUCL MED, vol. 17, no. 2, 2018, pages 94 - 101
KAIDANOVICH-BEILIN, O. ET AL.: "Assessment of social interaction behaviors", J VIS EXP, 2011, pages 48
ROULLET, F.I.J.N. CRAWLEY: "Mouse models of autism: testing hypotheses about molecular mechanisms", CURR TOP BEHAV NEUROSCI, vol. 7, 2011, pages 187 - 212
ANGOA-PEREZ, M. ET AL.: "Marble burying and nestlet shredding as tests of repetitive, compulsive-like behaviors in mice", J VIS EXP, no. 82, 2013, pages 50978
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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