Title:
BIOMARKER FOR DIAGNOSING NONALCOHOLIC STEATOHEPATITIS USING MICRORNA COMBINATION
Document Type and Number:
WIPO Patent Application WO/2022/025387
Kind Code:
A1
Abstract:
The present invention relates to miRNA-4449, which is a biomarker that can be used to diagnose nonalcoholic steatohepatitis, and at least one miRNA selected from the group consisting of miRNA-15, miRNA-21, miRNA-29, miRNA-126, miRNA-151, miRNA-183, and miRNA-192. The prognosis of nonalcoholic steatohepatitis among nonalcoholic fatty liver diseases is poor unlike simple steatosis. According to the present invention, the level of the miRNA can be measured in the serum of a patient to provide an accurate diagnostic result of nonalcoholic steatohepatitis, thus making it possible to eliminate side effects caused by conventional invasive test methods, and enabling early diagnosis and appropriate treatment of steatohepatitis in a simple and economical manner.
Inventors:
LEE YOUNG-SUN (KR)
Application Number:
PCT/KR2021/004389
Publication Date:
February 03, 2022
Filing Date:
April 08, 2021
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C12Q1/6883; A61K31/7088; A61P1/16; A61P3/00
Foreign References:
| KR20200002241A | 2020-01-08 | |||
| KR20140147919A | 2014-12-31 | |||
| KR20180085533A | 2018-07-27 | |||
| KR20150003846A | 2015-01-09 | |||
| JP2017074077A | 2017-04-20 |
Other References:
YUNFENG SHEN, MEIMEI LIU, CHAO CHEN, XIAOYANG LAI, MEIYING ZHANG: "MicroRNA profile changes in liraglutide treated steatotic HepG2 cells", INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE : IJCEM, vol. 10, no. 3, 1 January 2017 (2017-01-01), US , pages 4856 - 4864, XP009533634, ISSN: 1940-5901
PIROLA CARLOS J; FERNANDEZ GIANOTTI TOMAS; CASTANO GUSTAVO O; MALLARDI PABLO; SAN MARTINO JULIO; LOPEZ LEDESMA MARIA MORA GONZALEZ: "Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis", GUT MICROBIOTA, BRITISH MEDICAL ASSOCIATION , LONDON, UK, vol. 64, no. 5, 1 May 2015 (2015-05-01), UK , pages 800 - 812, XP008180955, ISSN: 0017-5749
KIM TAE HYUNG, LEE YOONSEOK, LEE YOUNG-SUN, GIM JEONG-AN, KO EUNJUNG, YIM SUN YOUNG, JUNG YOUNG KUL, KANG SEONGHEE, KIM MOON YOUNG: "Circulating miRNA is a useful diagnostic biomarker for nonalcoholic steatohepatitis in nonalcoholic fatty liver disease", SCIENTIFIC REPORTS, vol. 11, no. 1, 1 December 2021 (2021-12-01), XP055890325, ISSN: 2045-2322, DOI: 10.1038/s41598-021-94115-6
See also references of EP 4190915A4
PIROLA CARLOS J; FERNANDEZ GIANOTTI TOMAS; CASTANO GUSTAVO O; MALLARDI PABLO; SAN MARTINO JULIO; LOPEZ LEDESMA MARIA MORA GONZALEZ: "Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis", GUT MICROBIOTA, BRITISH MEDICAL ASSOCIATION , LONDON, UK, vol. 64, no. 5, 1 May 2015 (2015-05-01), UK , pages 800 - 812, XP008180955, ISSN: 0017-5749
KIM TAE HYUNG, LEE YOONSEOK, LEE YOUNG-SUN, GIM JEONG-AN, KO EUNJUNG, YIM SUN YOUNG, JUNG YOUNG KUL, KANG SEONGHEE, KIM MOON YOUNG: "Circulating miRNA is a useful diagnostic biomarker for nonalcoholic steatohepatitis in nonalcoholic fatty liver disease", SCIENTIFIC REPORTS, vol. 11, no. 1, 1 December 2021 (2021-12-01), XP055890325, ISSN: 2045-2322, DOI: 10.1038/s41598-021-94115-6
See also references of EP 4190915A4
Attorney, Agent or Firm:
MUHANN PATENT & LAW FIRM (KR)
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