Title:
BIOMARKER FOR EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/014834
Kind Code:
A1
Abstract:
The present invention relates to a biomarker for the early diagnosis of Alzheimer's disease and a use thereof, and more particularly, the present invention relates to: a biomarker composition for the early diagnosis of Alzheimer's disease, the biomarker composition comprising one or more genes selected from the group consisting of alpha-2-macroglobulin (A2M), creatine kinase M-type (CKM), filamin-A (FLNA), integral alpha-IIb (ITGA2B), alpha-1-acid glycoprotein 2 (ORM2), phospholipid transfer protein (PLTP), haptoglobin (HP), sulfhydryl oxidase 1 (QSOX1), protein-glutamine gamma-glutamyltransferase 2 (TGM2), filamin C (FLNC), heat shock protein 70 (HSP70) and lysomal alpha-mannosidase (heat shock protein MAN2B1), or a protein expressed from the genes; a method for the early diagnosis of Alzheimer's disease; a diagnostic kit for the early diagnosis of Alzheimer's disease; and a method for providing information for predicting and diagnosing Alzheimer's disease.
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Inventors:
YOON JONG HYUK (KR)
JO YEON SUK (KR)
PARK GEUN A (KR)
BAE SUNG WON (KR)
KWON YANG WOO (KR)
LEE SEUL AH (KR)
JANG KUK IN (KR)
LEE CHAN Y (KR)
OH YONG SEOK (KR)
LEE HA GYEONG (KR)
KWON DA YOUNG (KR)
JO YEON SUK (KR)
PARK GEUN A (KR)
BAE SUNG WON (KR)
KWON YANG WOO (KR)
LEE SEUL AH (KR)
JANG KUK IN (KR)
LEE CHAN Y (KR)
OH YONG SEOK (KR)
LEE HA GYEONG (KR)
KWON DA YOUNG (KR)
Application Number:
PCT/KR2023/009845
Publication Date:
January 18, 2024
Filing Date:
July 11, 2023
Export Citation:
Assignee:
DAEGU GYEONGBUK INST SCIENCE & TECH (KR)
International Classes:
C12Q1/6883; G01N33/68
Domestic Patent References:
| WO2021071219A1 | 2021-04-15 |
Foreign References:
| US20110236917A1 | 2011-09-29 | |||
| JP2020144147A | 2020-09-10 |
Other References:
HYE, A. ET AL.: "Proteome-based plasma biomarkers for Alzheimer's disease.", BRAIN, vol. 129, 2006, pages 3042 - 3050, XP002606813, DOI: 10.1093/brain/awl279
VARMA, V. R. ET AL.: "Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway.", MOLECULAR PSYCHIATRY., vol. 22, 2017, pages 13 - 23, XP037651904, DOI: 10.1038/mp.2016.206
VARMA, V. R. ET AL.: "Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway.", MOLECULAR PSYCHIATRY., vol. 22, 2017, pages 13 - 23, XP037651904, DOI: 10.1038/mp.2016.206
Attorney, Agent or Firm:
NAM & NAM (KR)
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