Title:
BIOMARKER FOR PREDICTING LIKELIHOOD OF DEVELOPING GASTRIC CANCER AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/234485
Kind Code:
A1
Abstract:
The present invention relates to a biomarker for predicting the likelihood of developing gastric cancer and use thereof, in which, by measuring an mRNA level of any at least one gene selected from the group consisting of CDK1, KDF1, CREB5, and AKT2 or a level of a protein expressed therefrom, the likelihood of developing gastric cancer including metachronous gastric cancer can be predicted. A composition for predicting the likelihood of developing gastric cancer, according to the present invention, not only has high accuracy in predicting the onset of gastric cancer, but also enables the prediction of gastric cancer through a one-time measurement method by using multi-plex PCR with a single tissue sample, and thus is highly usable. In addition, since a quantitative method for predicting the onset of gastric cancer as well as metachronous gastric cancer includes a method for quantifying basal gastritis, provided is a method for predicting the risk of developing gastric cancer in normal individuals with a family history of gastric cancer or risk factors. Moreover, there is the effect of predicting prognoses of patients by predicting the onset of metachronous gastric cancer in early gastric cancer patients who are treated by endoscopic submucosal dissection.
Inventors:
CHO SOO JEONG (KR)
KIM SANG GYUN (KR)
PARK MIREE (KR)
KIM SANG GYUN (KR)
PARK MIREE (KR)
Application Number:
PCT/KR2022/014463
Publication Date:
December 07, 2023
Filing Date:
September 27, 2022
Export Citation:
Assignee:
SEOUL NAT UNIV HOSPITAL (KR)
International Classes:
C12Q1/6886; G01N33/574
Domestic Patent References:
| WO2020226333A1 | 2020-11-12 |
Foreign References:
| CN113555121A | 2021-10-26 | |||
| KR20120065959A | 2012-06-21 |
Other References:
WEI KANG;JOANNA HM TONG;RAYMOND WM LUNG;YUJUAN DONG;WEIQIN YANG;YI PAN;KIN MANG LAU;JUN YU;ALFRED SL CHENG;KA FAI TO: "let-7b/g silencing activates AKT signaling to promote gastric carcinogenesis", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, vol. 12, no. 1, 5 October 2014 (2014-10-05), pages 281, XP021200372, ISSN: 1479-5876, DOI: 10.1186/s12967-014-0281-3
JIRO WATARI; , KENTARO MORIICHI; , HIROKI TANABE; SHIN KASHIMA; YOSHIKI NOMURA; MIKIHIRO FUJIYA; TOSHIHIKO TOMITA; TADAYUKI OSHIMA: "Biomarkers predicting development of metachronous gastric cancer after endoscopic resection: an analysis of molecular pathology of Helicobacter pylori eradication", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC., US, vol. 130, no. 10, 24 August 2011 (2011-08-24), US , pages 2349 - 2358, XP071286894, ISSN: 0020-7136, DOI: 10.1002/ijc.26275
KIM, B.: "Candidate Gene Identification for Prediction of Metachronous Gastric Cancer Development using RNA Sequencing in Patients with Early Gastric Cancer Treated with Endoscopic Submucosal Dissection", KOREA INTERNATIONAL GASTRIC CANCER WEEK 2021 VIRTUAL CONFERENCE, P-067, 30 September 2021 (2021-09-30)
BOKYUNG KIM, JUNGMIN CHOI, HARIM CHUN, MIREE PARK, SEUNGKYUNG KANG, EUNWOO LEE, HAN MYUNG LEE, HYUNSOO CHUNG, SANG GYUN KIM, SOO-J: "FP19-04: KDF1 and CDK1 are Candidate Markers for Prediction of Metachronous Gastric Cancer Development in Patients with Early Gastric Cancer Treated Endoscopic Submucosal Dissection", GUT AND LIVER, GUT AND LIVER, EDITORIAL OFFICE, KR, vol. 15, no. 6, Suppl. 1, 18 November 2021 (2021-11-18) - 20 November 2021 (2021-11-20), KR , pages 44, XP009551519, ISSN: 1976-2283
JIRO WATARI; , KENTARO MORIICHI; , HIROKI TANABE; SHIN KASHIMA; YOSHIKI NOMURA; MIKIHIRO FUJIYA; TOSHIHIKO TOMITA; TADAYUKI OSHIMA: "Biomarkers predicting development of metachronous gastric cancer after endoscopic resection: an analysis of molecular pathology of Helicobacter pylori eradication", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC., US, vol. 130, no. 10, 24 August 2011 (2011-08-24), US , pages 2349 - 2358, XP071286894, ISSN: 0020-7136, DOI: 10.1002/ijc.26275
KIM, B.: "Candidate Gene Identification for Prediction of Metachronous Gastric Cancer Development using RNA Sequencing in Patients with Early Gastric Cancer Treated with Endoscopic Submucosal Dissection", KOREA INTERNATIONAL GASTRIC CANCER WEEK 2021 VIRTUAL CONFERENCE, P-067, 30 September 2021 (2021-09-30)
BOKYUNG KIM, JUNGMIN CHOI, HARIM CHUN, MIREE PARK, SEUNGKYUNG KANG, EUNWOO LEE, HAN MYUNG LEE, HYUNSOO CHUNG, SANG GYUN KIM, SOO-J: "FP19-04: KDF1 and CDK1 are Candidate Markers for Prediction of Metachronous Gastric Cancer Development in Patients with Early Gastric Cancer Treated Endoscopic Submucosal Dissection", GUT AND LIVER, GUT AND LIVER, EDITORIAL OFFICE, KR, vol. 15, no. 6, Suppl. 1, 18 November 2021 (2021-11-18) - 20 November 2021 (2021-11-20), KR , pages 44, XP009551519, ISSN: 1976-2283
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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