BIOMARKER FOR PREDICTING PROGNOSIS OF CANCER

WIPO Patent Application WO/2010/064702

A1

Disclosed are: a genetic signature useful for the diagnosis of cancer, particularly lung cancer; a method for diagnosing cancer utilizing the signature; a test method for predicting the prognosis of cancer, which comprises a step of determining the expression level of a prognosis-related gene, i.e., the expression level of a transcript of the gene or a translation product of the gene, in a biological sample collected from a cancer patient, wherein the gene is selected from 277 genes included in a prognosis-related genetic signature (1) (the prognosis-related genetic signature (1) is as defined in the description); and a diagnostic agent for predicting the prognosis of cancer, which comprises a reagent for detecting the expression level of the prognosis-related gene.

GOTOH NORIKO (JP)
MIYANO SATORU (JP)
IMOTO SEIYA (JP)
YAMAUCHI MAI (JP)
YAMAGUCHI RUI (JP)
KOHNO TAKASHI (JP)
YOKOTA JUN (JP)

PCT/JP2009/070386

June 10, 2010

December 04, 2009

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UNIV TOKYO (JP)
JAPAN HEALTH SCIENCE FOUND (JP)
GOTOH NORIKO (JP)
MIYANO SATORU (JP)
IMOTO SEIYA (JP)
YAMAUCHI MAI (JP)
YAMAGUCHI RUI (JP)
KOHNO TAKASHI (JP)
YOKOTA JUN (JP)

C12Q1/68; C12M1/00; C12N15/09; G01N33/53; G01N33/574; G01N37/00

JP2006521793A	2006-09-28
JP2007506442A	2007-03-22

HITOSHI ZENBUTSU ET AL.: "Nude Mice Xenograft o Mochiita EGFR Sogaizai ni Taisuru Kanjusei Shiken to cDNA Maico Array ni yoru Keijiteki Idenshi Hatsugen Profile no Kaiseki", NIHON GAN GAKKAI GAKUJUTSU SOKAI KIJI, vol. 61, 2002, pages 166, 1057
BASELGA, J. ET AL.: "Strategies to optimise anti-EGF receptor therapies", EUROPEAN JOURNAL OF CANCER, vol. 38, 2002, pages S4, 6

TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)

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