Title:
BISPECIFIC ANTIBODY BINDING TO CD40 AND FAP
Document Type and Number:
WIPO Patent Application WO/2020/230899
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a bispecific antibody that binds to CD40 and FAP and exhibits potent CD40 agonistic activity depending on FAP, a fragment of the bispecific antibody, etc. The present invention pertains to a bispecific antibody that comprises an IgG part including a first antigen-binding domain and a second antigen-binding domain and binds to human CD40 and human FAP, wherein the C-terminus of the heavy chain in the IgG part binds, either directly or via a linker, to the second antigen-binding domain, a fragment of the bispecific antibody, etc.
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Inventors:
TEZUKA YUTA (JP)
OSANAI AYA (JP)
USAMI KATSUAKI (JP)
NISHIYA HARUE (JP)
OSANAI AYA (JP)
USAMI KATSUAKI (JP)
NISHIYA HARUE (JP)
Application Number:
PCT/JP2020/019545
Publication Date:
November 19, 2020
Filing Date:
May 15, 2020
Export Citation:
Assignee:
KYOWA KIRIN CO LTD (JP)
International Classes:
A61K39/395; A61K47/55; A61K47/56; A61K47/62; A61K47/68; A61K49/00; A61P35/00; C07K16/18; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/62; C12N15/63; C12P21/08; G01N33/53; G01N33/574
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J. BACTERIOL., vol. 172, 1990, pages 2392
PROC. NATL. ACAD. SCI. USA, vol. 69, 1972, pages 2110
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CYTOTECHNOLOGY, vol. 3, 1990, pages 133
J. BIOCHEMISTRY, vol. 101, 1987, pages 1307
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NATURE, vol. 256, 1975, pages 495
P. J. DELVES.: "ANTIBODY PRODUCTION ESSENTIAL TECHNIQUES.", 1997, WILEY
ISHIDALONBERG, IBC'S 11TH ANTIBODY ENGINEERING, 2000
CYTOTECHNOL., vol. 13, 1993, pages 79
METHODS IN ENZYMOL., vol. 154, 1987, pages 3
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MOL. CELL. BIOL., vol. 3, 1983, pages 280
SCIENCE, vol. 222, 1983, pages 778
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J. MOL. BIOL., vol. 16, 1966, pages 118
PROC. NATL. ACAD. SCI. USA, vol. 74, 1977, pages 5463
"Sequences of Proteins of Immunological Interest", 1991, US DEPT. HEALTH AND HUMAN SERVICES
CYTOTECHNOL., vol. 4, 1990, pages 173
J. BIOCHEM., vol. 101, 1987, pages 1307
GENE, vol. 27, 1984, pages 223
PROC. NATL. ACAD. SCI. USA, vol. 78, 1981, pages 1527
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 149, 1987, pages 960
CELL, vol. 41, 1985, pages 479
CELL, vol. 33, 1983, pages 717
J. IMMUNOL. METHODS, vol. 167, 1994, pages 271
J. MOL. BIOL., vol. 112, 1977, pages 535
"Monoclonal Antibodies-Principles and practice", 1996, ACADEMIC PRESS
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
NATURE, vol. 227, 1970, pages 680
EMMANUELLE LAFFY, HUMAN ANTIBODIES, vol. 14, 2005, pages 33 - 55
"Fluorescent Antibody Method", 1983, SOFT SCIENCE, INC.
"Genbank", Database accession no. NM_007986
ISHIDA, I. ET AL., CLONING & STEM CELLS, vol. 4, 2002, pages 85 - 96
ISAMU ISHIDA, EXPERIMENTAL MEDICINE, vol. 20, no. 6, 2002, pages 846 - 851
NATURE BIOTECHNOLOY, vol. 19, 2001, pages 75 - 78
CLIN CANCER RES, vol. 11, no. 8, 2005, pages 3126 - 3135
See also references of EP 3970743A4
GUAN-MIN JIANG ET AL., ONCOTARGET, vol. 7, no. 22, 31 May 2016 (2016-05-31), pages 33472 - 82
BEATTY GL ET AL., EXPERT REV ANTICANCER THER., vol. 17, no. 2, February 2017 (2017-02-01), pages 175 - 186
VONDERHEIDE RH ET AL., ONCOIMMUNOLOGY, vol. 2, no. 1, 1 January 2013 (2013-01-01), pages e23033
FIEDLER U. ET AL., AACR ANNUAL MEETING, 2018, pages 4552
RIGAMONTI N. ET AL., SITC 33RD ANNUAL MEETING, 2018
"GenBank", Database accession no. XM _011766922
AGRIC. BIOL. CHEM., vol. 53, 1989, pages 277
NUCLEIC ACIDS RESEARCH, vol. 10, 1982, pages 6487
PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409
GENE, vol. 38, 1985, pages 275
NUCLEIC ACIDS RESEARCH, vol. 13, 1985, pages 4431
PROCEEDING OF THE NATIONAL ACADEMY OF SCIENCES IN USA, vol. 82, 1985, pages 488
LAGRESLE ET AL., J IMMUNOL, vol. 154, 1995, pages 5746 - 5756
J. MOL. BIOL., vol. 215, 1990, pages 403
NUCLEIC ACIDS RESEARCH, vol. 25, 1997, pages 3389
GENOME RESEARCH, vol. 7, 1997, pages 649, Retrieved from the Internet
KABAT ET AL., SEQUENCES OF PROTEINS OF IMMUNOLOGICAL INTEREST, 1991
"Clinical oncology", JAPANESE JOURNAL OF CANCER AND CHEMOTHERAPY, 1996
"Antibodies - A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
NATURE, vol. 329, 1987, pages 840
NATURE PROTOCOLS, vol. 9, 2014, pages 2450 - 2463
PROC. NATL. ACAD. SCI., USA, vol. 79, 1982, pages 6409
PROC. NATL. ACAD. SCI USA, vol. 82, 1985, pages 488
BECK ET AL., ANALYTICAL CHEMISTRY, vol. 85, 2013, pages 715 - 736
ANNU. REV. IMMUNOL., vol. 9, pages 457 - 492
GENE, vol. 17, 1982, pages 107
AGRICULTURAL BIOLOGICAL CHEMISTRY, vol. 48, 1984, pages 669
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 4306
J. BACTERIOL., vol. 172, 1990, pages 2392
PROC. NATL. ACAD. SCI. USA, vol. 69, 1972, pages 2110
MOLECULAR & GENERAL GENETICS, vol. 168, 1979, pages 111
CYTOTECHNOLOGY, vol. 3, 1990, pages 133
J. BIOCHEMISTRY, vol. 101, 1987, pages 1307
PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 7413
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 199, 1967, pages 519
SCIENCE, vol. 122, 1952, pages 501
VIROLOGY, vol. 8, 1959, pages 396
PROC. SOC. EXP. BIOL. MED., vol. 73, 1950, pages 1
PAULSON ET AL., J. BIOL. CHEM., vol. 264, 1989, pages 17619
LOWE ET AL., PROC. NATL. ACAD. SCI., USA, vol. 86, 1989, pages 8227
GENES DEVELOP., vol. 4, 1990, pages 1288
TOMIZUKA ET AL., PROC NATL ACAD SCI USA., vol. 97, 2000, pages 722
EUROPEAN J. IMMUNOLOGY, vol. 6, 1976, pages 511
NATURE, vol. 276, 1978, pages 269
J. IMMUNOLOGY, vol. 123, 1979, pages 1548
NATURE, vol. 256, 1975, pages 495
P. J. DELVES.: "ANTIBODY PRODUCTION ESSENTIAL TECHNIQUES.", 1997, WILEY
ISHIDALONBERG, IBC'S 11TH ANTIBODY ENGINEERING, 2000
CYTOTECHNOL., vol. 13, 1993, pages 79
METHODS IN ENZYMOL., vol. 154, 1987, pages 3
NUCLEIC ACIDS RESEARCH, vol. 17, 1989, pages 9494
MOL. CELL. BIOL., vol. 3, 1983, pages 280
SCIENCE, vol. 222, 1983, pages 778
J. MOL. BIOL., vol. 166, 1983, pages 1
J. MOL. BIOL., vol. 16, 1966, pages 118
PROC. NATL. ACAD. SCI. USA, vol. 74, 1977, pages 5463
"Sequences of Proteins of Immunological Interest", 1991, US DEPT. HEALTH AND HUMAN SERVICES
CYTOTECHNOL., vol. 4, 1990, pages 173
J. BIOCHEM., vol. 101, 1987, pages 1307
GENE, vol. 27, 1984, pages 223
PROC. NATL. ACAD. SCI. USA, vol. 78, 1981, pages 1527
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 149, 1987, pages 960
CELL, vol. 41, 1985, pages 479
CELL, vol. 33, 1983, pages 717
J. IMMUNOL. METHODS, vol. 167, 1994, pages 271
J. MOL. BIOL., vol. 112, 1977, pages 535
"Monoclonal Antibodies-Principles and practice", 1996, ACADEMIC PRESS
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
NATURE, vol. 227, 1970, pages 680
EMMANUELLE LAFFY, HUMAN ANTIBODIES, vol. 14, 2005, pages 33 - 55
"Fluorescent Antibody Method", 1983, SOFT SCIENCE, INC.
"Genbank", Database accession no. NM_007986
ISHIDA, I. ET AL., CLONING & STEM CELLS, vol. 4, 2002, pages 85 - 96
ISAMU ISHIDA, EXPERIMENTAL MEDICINE, vol. 20, no. 6, 2002, pages 846 - 851
NATURE BIOTECHNOLOY, vol. 19, 2001, pages 75 - 78
CLIN CANCER RES, vol. 11, no. 8, 2005, pages 3126 - 3135
See also references of EP 3970743A4
Attorney, Agent or Firm:
Eikoh Patent Firm, P.C. (JP)
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