Title:
BISPHOSPHONATE-CONTAINING CARBON PARTICLE COMPOSITE AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2021/161987
Kind Code:
A1
Abstract:
Provided are: a BP-containing carbon particle composite having improved BP action and suppressed side effects; and a method for producing the same. Provided is a carbon particle composite containing a calcium phosphate, a bisphosphonate, and carbon particles. The carbon particles may be carbon nanohorns, carbon nanotubes, nanographenes, nanodiamonds, and carbon fibers, or a combination thereof. The carbon particles may also be carbon oxide nanohorns.
Inventors:
YUDASAKA MASAKO (JP)
NAKAMURA MAKI (JP)
SAITO NAOTO (JP)
AOKI KAORU (JP)
UEDA KATSUYA (JP)
NAKAMURA MAKI (JP)
SAITO NAOTO (JP)
AOKI KAORU (JP)
UEDA KATSUYA (JP)
Application Number:
PCT/JP2021/004744
Publication Date:
August 19, 2021
Filing Date:
February 09, 2021
Export Citation:
Assignee:
AIST (JP)
UNIV SHINSHU (JP)
UNIV SHINSHU (JP)
International Classes:
A61K31/663; A61K31/675; A61K47/02; A61K47/30; A61K47/69; A61P19/08
Foreign References:
| CN111012948A | 2020-04-17 | |||
| US20180104380A1 | 2018-04-19 |
Other References:
DLAMINI N. L., MUKAYA H. E., VAN ZYL R. L., JANSEN VAN VUUREN N. C., MBIANDA X. Y.: "Carbon nanospheres conjugated bisphosphonates: synthesis, characterization and in vitro antimalarial activity", ARTIFICIAL CELLS, NANOMEDICINE AND BIOTECHNOLOGY, TAYLOR & FRANCIS INC., US, vol. 46, no. sup3, 12 November 2018 (2018-11-12), US, pages S287 - S296, XP055849071, ISSN: 2169-1401, DOI: 10.1080/21691401.2018.1491481
FERNANDES RENATA SALGADO, LEMOS JANAINA ALCÂNTARA, BRANCO DE BARROS ANDRÉ LUÍS, GERALDO VIVIANY, ELETO DA SILVA EDELMA, ALISARAIE : "Carboxylated versus bisphosphonate SWCNT: Functionalization effects on the biocompatibility and in vivo behaviors in tumor-bearing mice", JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, ED. DE SANTÉ, FR, vol. 50, 1 April 2019 (2019-04-01), FR, pages 266 - 277, XP055849072, ISSN: 1773-2247, DOI: 10.1016/j.jddst.2019.01.036
NAKAMURA MAKI, UEDA KATSUYA, YAMAMOTO YUMIKO, AOKI KAORU, ZHANG MINFANG, SAITO NAOTO, YUDASAKA MASAKO: "Ibandronate-Loaded Carbon Nanohorns Fabricated Using Calcium Phosphates as Mediators and Their Effects on Macrophages and Osteoclasts", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 3, 27 January 2021 (2021-01-27), US, pages 3701 - 3712, XP055849073, ISSN: 1944-8244, DOI: 10.1021/acsami.0c20923
FERNANDES RENATA SALGADO, LEMOS JANAINA ALCÂNTARA, BRANCO DE BARROS ANDRÉ LUÍS, GERALDO VIVIANY, ELETO DA SILVA EDELMA, ALISARAIE : "Carboxylated versus bisphosphonate SWCNT: Functionalization effects on the biocompatibility and in vivo behaviors in tumor-bearing mice", JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, ED. DE SANTÉ, FR, vol. 50, 1 April 2019 (2019-04-01), FR, pages 266 - 277, XP055849072, ISSN: 1773-2247, DOI: 10.1016/j.jddst.2019.01.036
NAKAMURA MAKI, UEDA KATSUYA, YAMAMOTO YUMIKO, AOKI KAORU, ZHANG MINFANG, SAITO NAOTO, YUDASAKA MASAKO: "Ibandronate-Loaded Carbon Nanohorns Fabricated Using Calcium Phosphates as Mediators and Their Effects on Macrophages and Osteoclasts", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 3, 27 January 2021 (2021-01-27), US, pages 3701 - 3712, XP055849073, ISSN: 1944-8244, DOI: 10.1021/acsami.0c20923
Attorney, Agent or Firm:
TAKAHASHI, HAYASHI AND PARTNER PATENT ATTORNEYS, INC. (JP)
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