Title:
BLOCK COPOLYMERS OF LACTONES AND POLY(PROPYLENE FUMARATE)
Document Type and Number:
WIPO Patent Application WO/2018/142384
Kind Code:
A3
Abstract:
In various embodiments, the present invention provides well-defined biodegradable poly(lactone-b-propylene fumarate) diblock and triblock polymers formed using a novel one-pot, scalable ring-opening block-order copolymerization (ROBOCOP) technique that utilizes magnesium 2,6-di-tert-butyl-4-methylphenoxide (Mg(BHT)2(THF)2) to "switch" from the ROP of cyclic esters to the ROCOP of maleic anhydride (MAn) and propylene oxide (PO) to produce PPF based block copolymers for application in additive manufacturing and patient specific regenerative medicine. These block copolymers are fully resorbable and can be photochemically crosslinked in a number of applications, including 3D printing. By adding the lactone block to the PPF polymer, the viscosity of the resulting block copolymer at working temperatures can be precisely controlled and the quantity of the reactive diluent in printable resins can be reduced or eliminated.
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Inventors:
BECKER MATTHEW (US)
WILSON JAMES (GB)
PETERSEN SHANNON (US)
WILSON JAMES (GB)
PETERSEN SHANNON (US)
Application Number:
PCT/IB2018/051867
Publication Date:
October 11, 2018
Filing Date:
March 20, 2018
Export Citation:
Assignee:
BECKER MATTHEW (US)
WILSON JAMES (GB)
PETERSEN SHANNON (US)
UNIV AKRON (US)
WILSON JAMES (GB)
PETERSEN SHANNON (US)
UNIV AKRON (US)
International Classes:
C08G69/14; C08G75/14; C08G81/00
Foreign References:
| US20080004368A1 | 2008-01-03 | |||
| US20080262102A1 | 2008-10-23 |
Other References:
JAYABALAN: "Studies on Poly(propylene fumarate-co-caprolactone diol) Thermoset Composites towards the Development of Biodegradable Bone Fixation Devices", INTERNATIONAL JOURNAL OF BIOMATERIALS, vol. 2009, 2009, pages 1 - 10, XP055549299
WILSON ET AL.: "Immortal' ring-opening polymerization of w-pentadecalactone by Mg(BHT)2(THF)2", POLYMER CHEMISTRY, vol. 5, 25 February 2014 (2014-02-25), pages 2691 - 2694, XP055549304
LUO ET AL.: "Synthesis and Biological Evaluation of Well-Defined Poly(propylene fumarate) Oligomers and Their Use in 3D Printed Scaffolds", BIOMACROMOLECULES, vol. 17, 15 January 2016 (2016-01-15), pages 690 - 697, XP055549309
WILSON ET AL.: "Immortal' ring-opening polymerization of w-pentadecalactone by Mg(BHT)2(THF)2", POLYMER CHEMISTRY, vol. 5, 25 February 2014 (2014-02-25), pages 2691 - 2694, XP055549304
LUO ET AL.: "Synthesis and Biological Evaluation of Well-Defined Poly(propylene fumarate) Oligomers and Their Use in 3D Printed Scaffolds", BIOMACROMOLECULES, vol. 17, 15 January 2016 (2016-01-15), pages 690 - 697, XP055549309
Attorney, Agent or Firm:
DIAZ, Robert et al. (US)
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