Title:
BODIPY-BASED DIAMOND-SHAPED METAL RING, METHOD FOR PREPARING SAME, AND USE THEREOF IN NEAR-INFRARED EMISSION
Document Type and Number:
WIPO Patent Application WO/2023/201873
Kind Code:
A1
Abstract:
Disclosed are a BODIPY-based diamond-shaped metal ring, and a method for preparing same, and use thereof in near-infrared emission. According to the present invention, a BODIPY-based 120-degree bipyridine BODIPY ligand molecule 1 having near-infrared I window absorption and a 60-degree methoxy platinum receptor molecule 2 self-assemble by means of Pt-N metal coordinate bonds to form the BODIPY-based diamond-shaped metal ring M. The BODIPY-based diamond-shaped supermolecule metal ring has good solubility and near-infrared fluorescence emission performance. By wrapping the metal ring with a commercial amphiphilic polymer carrier F127, the present invention provides an F127/M nanoparticle having excellent efficacy in photodynamic therapy and photothermal therapy in vitro.
Inventors:
YIN SHOUCHUN (CN)
LI YANG (CN)
QIU HUAYU (CN)
LI YANG (CN)
QIU HUAYU (CN)
Application Number:
PCT/CN2022/100790
Publication Date:
October 26, 2023
Filing Date:
June 23, 2022
Export Citation:
Assignee:
UNIV HANGZHOU NORMAL (CN)
International Classes:
C07F5/02; A61K9/51; A61K41/00; A61K47/10; A61P35/00; C07F15/00; C09K11/06
Foreign References:
| CN108299625A | 2018-07-20 | |||
| CN113861229A | 2021-12-31 |
Other References:
RAMU VANITHA, GAUTAM SRISHTI, GARAI ADITYA, KONDAIAH PATURU, CHAKRAVARTY AKHIL R.: "Glucose-Appended Platinum(II)-BODIPY Conjugates for Targeted Photodynamic Therapy in Red Light", INORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON , US, vol. 57, no. 4, 19 February 2018 (2018-02-19), Easton , US , pages 1717 - 1726, XP093101203, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.7b02249
RAMU VANITHA, GAUTAM SRISHTI, KONDAIAH PATURU, CHAKRAVARTY AKHIL R.: "Diplatinum(II) Catecholate of Photoactive Boron-Dipyrromethene for Lysosome-Targeted Photodynamic Therapy in Red Light", INORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON , US, vol. 58, no. 14, 15 July 2019 (2019-07-15), Easton , US , pages 9067 - 9075, XP093102147, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.9b00567
RAMU VANITHA, GAUTAM SRISHTI, KONDAIAH PATURU, CHAKRAVARTY AKHIL R.: "Diplatinum(II) Catecholate of Photoactive Boron-Dipyrromethene for Lysosome-Targeted Photodynamic Therapy in Red Light", INORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON , US, vol. 58, no. 14, 15 July 2019 (2019-07-15), Easton , US , pages 9067 - 9075, XP093102147, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.9b00567
Attorney, Agent or Firm:
HANGZHOU JUNDU PATENT FIRM LLP (CN)
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