Title:
BORDETELLA T CELL EPITOPES, MEGAPOOLS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/006842
Kind Code:
A3
Abstract:
The present invention includes compositions, including epitope megapools, and methods for detecting the presence of: a Bordetella or an immune response relevant to a Bordetella infection including T cells responsive to one or more Bordetella peptides or proteins comprising, consisting of, or consisting essentially of: one or more amino acid sequences, fusion proteins, a pool of 2 or more peptides, or polynucleotides that expression the amino acid sequences selected from those set forth in any one of Tables 1-20 (SEQ ID NOS: 1 to 2598). The invention further provides vaccines, diagnostics, therapies, and kits, comprising such proteins or peptides.
Inventors:
SETTE ALESSANDRO (US)
ANTUNES RICARDO (US)
ANTUNES RICARDO (US)
Application Number:
PCT/US2023/069274
Publication Date:
March 21, 2024
Filing Date:
June 28, 2023
Export Citation:
Assignee:
LA JOLLA INST FOR IMMUNOLOGY (US)
International Classes:
A61K39/02; A61K39/102; A61P37/04; C07K14/235; C12N15/70
Foreign References:
| US20220047690A1 | 2022-02-17 | |||
| US20130330335A1 | 2013-12-12 |
Other References:
A DI TOMMASO: "Identification of subregions of Bordetella pertussis filamentous hemagglutinin that stimulate human T-cell responses", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 59, no. 9, 1 September 1991 (1991-09-01), US , pages 3313 - 3315, XP093152793, ISSN: 0019-9567, DOI: 10.1128/iai.59.9.3313-3315.1991
Attorney, Agent or Firm:
FLORES, Edwin, S. et al. (US)
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