Title:
BOTULINUM TOXIN A PEPTIDES AND METHODS OF PREDICTING AND REDUCING IMMUNORESISTANCE TO BOTULINUM TOXIN THERAPY
Document Type and Number:
WIPO Patent Application WO2005030119
Kind Code:
A3
Abstract:
The present invention provides BoNT/A peptides as well as methods of predicting or determining immunoresistance to botulinum toxin therapy in an individual using BoNT/A peptides.
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Inventors:
ATASSI M ZOUHAIR (US)
Application Number:
PCT/US2004/011228
Publication Date:
June 23, 2005
Filing Date:
April 09, 2004
Export Citation:
Assignee:
ALLERGAN INC (US)
ATASSI M ZOUHAIR (US)
ATASSI M ZOUHAIR (US)
International Classes:
A61K38/48; C07K14/33; C07K16/12; G01N33/569; (IPC1-7): G01N33/53
Foreign References:
| US20020197278A1 | 2002-12-26 |
Other References:
NAUMANN M. ET AL: "Depletion of neutralising antibodies resensitises a secondary non-responder to botulinum A neurotoxin", JOURNAL OF NEUROLOGY, vol. 65, 1998, pages 924 - 927, XP000979025
ROSENBERG J.S. ET AL: "Localization of the regions on the C-terminal domain of the heavy chain of botulinum A recognized by T lymphocytes and by antibodies after immunization of mice with pentavalent toxoid", IMMUNOLOGICAL INVESTIGATIONS, vol. 26, no. 4, 1997, pages 491 - 504, XP008046810
DERTZBAUGH M.T. ET AL: "Mapping of protective and cross-reactive domains of the type A neurotoxin of Clostridium botulinum", VACCINE, vol. 14, no. 16, November 1996 (1996-11-01), pages 1538 - 1544, XP004063310
OSHIMA M. ET AL: "Immune recognition of botulinum neurotoxin type A: regions recognized by T cellsand antibodies against the protective Hc fragment (residues 855-1296) of the toxin", MOLECULAR IMMUNOLOGY, vol. 34, no. 14, 1997, pages 1031 - 1040, XP002986039
SINGH B.R. ET AL: "Immunochemical characterization of Type A botulinum neurotoxin in its purified and complexed forms", TOXICON, vol. 36, no. 2, 1996, pages 267 - 275, XP002986040
OSHIMA M. ET AL: "Antibodies and T cells against synthetic peptides of the C-terminal domain (Hc) of botulinum neurotoxin type A and their cross-reaction with Hc", IMMUNOLOGY LETTERS, vol. 60, 1998, pages 7 - 12, XP002986041
ROSENBERG J.S. ET AL: "Localization of the regions on the C-terminal domain of the heavy chain of botulinum A recognized by T lymphocytes and by antibodies after immunization of mice with pentavalent toxoid", IMMUNOLOGICAL INVESTIGATIONS, vol. 26, no. 4, 1997, pages 491 - 504, XP008046810
DERTZBAUGH M.T. ET AL: "Mapping of protective and cross-reactive domains of the type A neurotoxin of Clostridium botulinum", VACCINE, vol. 14, no. 16, November 1996 (1996-11-01), pages 1538 - 1544, XP004063310
OSHIMA M. ET AL: "Immune recognition of botulinum neurotoxin type A: regions recognized by T cellsand antibodies against the protective Hc fragment (residues 855-1296) of the toxin", MOLECULAR IMMUNOLOGY, vol. 34, no. 14, 1997, pages 1031 - 1040, XP002986039
SINGH B.R. ET AL: "Immunochemical characterization of Type A botulinum neurotoxin in its purified and complexed forms", TOXICON, vol. 36, no. 2, 1996, pages 267 - 275, XP002986040
OSHIMA M. ET AL: "Antibodies and T cells against synthetic peptides of the C-terminal domain (Hc) of botulinum neurotoxin type A and their cross-reaction with Hc", IMMUNOLOGY LETTERS, vol. 60, 1998, pages 7 - 12, XP002986041
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