Title:
TARGETED RELEASE OF NITRIC OXIDE IN THE CNS CIRCULATION FOR MODULATING THE BBB AND TREATING DISORDERS
Document Type and Number:
WIPO Patent Application WO2005030118
Kind Code:
A3
Abstract:
A method for delivering molecules to a central nervous system (CNS) of a subject includes supplying the molecules to a blood circulation of the CNS; supplying, to a body of the subject, a carrier system (24, 40) that encapsulates a nitric oxide (NO) facilitator; and applying energy to the carrier system at an energy level sufficient to cause the carrier system to release the NO facilitator in a blood circulation of the subject in a vicinity of a blood-brain barrier (BBB) of the subject and thereby increase passage of the molecules from the blood circulation of the CNS, through the BBB, and into the CNS of the subject.
Inventors:
NATAN AMIR (IL)
SHALEV ALON (IL)
SHALEV ALON (IL)
Application Number:
PCT/IL2004/000911
Publication Date:
August 31, 2006
Filing Date:
October 03, 2004
Export Citation:
Assignee:
BRAINSGATE LTD (IL)
NATAN AMIR (IL)
SHALEV ALON (IL)
NATAN AMIR (IL)
SHALEV ALON (IL)
International Classes:
A61N1/30; A61K31/21; A61K33/00; A61K41/00; A61K45/06; A61N1/40; A61N2/02
Foreign References:
| US6514221B2 | 2003-02-04 |
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