Title:
BRAIN CELL PROTECTIVE
Document Type and Number:
WIPO Patent Application WO/1995/003307
Kind Code:
A1
Abstract:
A novel brain cell protective containing a morphinane derivative represented by the compound of formula (1) or a pharmacologically acceptable acid-addition salt thereof as the active ingredient. This compound exhibits an excellent protective effect against cranial nerve cell necrosis in both in vitro and in vivo pharmacological tests, and hence can be used for preventing or treating ischemic encephalopathy, cranial nerve cell disorder, and dementia.
Inventors:
NAGASE HIROSHI (JP)
IMAMURA YOSHIFUMI (JP)
ENDO TAKASHI (JP)
MATSUDA SUSUMU (JP)
MIYAUCHI YASUSHI (JP)
IMAMURA YOSHIFUMI (JP)
ENDO TAKASHI (JP)
MATSUDA SUSUMU (JP)
MIYAUCHI YASUSHI (JP)
Application Number:
PCT/JP1994/001186
Publication Date:
February 02, 1995
Filing Date:
July 19, 1994
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
NAGASE HIROSHI (JP)
IMAMURA YOSHIFUMI (JP)
ENDO TAKASHI (JP)
MATSUDA SUSUMU (JP)
MIYAUCHI YASUSHI (JP)
NAGASE HIROSHI (JP)
IMAMURA YOSHIFUMI (JP)
ENDO TAKASHI (JP)
MATSUDA SUSUMU (JP)
MIYAUCHI YASUSHI (JP)
International Classes:
A61K31/485; C07D489/00; (IPC1-7): C07D489/00; A61K31/485
Foreign References:
| JPS61271275A | 1986-12-01 | |||
| JPS4118826B1 | ||||
| JPS62277324A | 1987-12-02 |
Other References:
See also references of EP 0661283A4
J. MED. CHEM., vol. 27, 1984, pages 1727
T. KIRINO, BRAIN RESEARCH, vol. 239, 1982, pages 57
S.M. ROTHERMAN; J.W. OLNEY, TRENDS IN NEUROSCIENCE, vol. 10, 1987, pages 299
J. MED. CHEM., vol. 27, 1984, pages 1727
T. KIRINO, BRAIN RESEARCH, vol. 239, 1982, pages 57
S.M. ROTHERMAN; J.W. OLNEY, TRENDS IN NEUROSCIENCE, vol. 10, 1987, pages 299
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