Title:
MORPHINAN DERIVATIVE AND MEDICINAL USE
Document Type and Number:
WIPO Patent Application WO/1995/003308
Kind Code:
A1
Abstract:
A morphinan derivative represented by formula (1) or a pharmacologically acceptable acid-addition salt thereof, and analgesic, diuretic, antitussive and brain cell protective agents each containing the derivative or the salt as the active ingredient. These compounds have potent analgesic, diuretic and antitussive effects as a highly selective kappa-opioid agonist, and are useful as analgesic, diuretic and antitussive agents. In addition, they have a significant brain cell protective effect and are useful as a brain cell protective agent.
Inventors:
NAGASE HIROSHI
HAYAKAWA JUN
KAWAMURA HUNIAKI
KAWAI KOJI
ENDOH TAKASHI
HAYAKAWA JUN
KAWAMURA HUNIAKI
KAWAI KOJI
ENDOH TAKASHI
Application Number:
PCT/JP1994/001197
Publication Date:
February 02, 1995
Filing Date:
July 20, 1994
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
International Classes:
C07D489/00; C07D489/08; (IPC1-7): C07D489/00; A61K31/485
Foreign References:
| JPS61271275A | 1986-12-01 | |||
| JPS62258380A | 1987-11-10 | |||
| JPS62277324A | 1987-12-02 | |||
| JPH01149788A | 1989-06-12 |
Other References:
See also references of EP 0663401A4
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