Title:
BRANCHED DEGRADABLE POLYETHYLENE GLYCOL BINDER
Document Type and Number:
WIPO Patent Application WO/2020/203626
Kind Code:
A1
Abstract:
The present invention provides a biologically-related substance to which a branched degradable polyethylene glycol derivative being decomposed in cells and being represented by formula (A) below is bound. (In the formula, each symbol is as defined in the present specification.)
Inventors:
YOSHIOKA HIROKI (JP)
OSAKAMA KAZUKI (JP)
HAMURA MIKA (JP)
INABA TAKANORI (JP)
NISHIYAMA NOBUHIRO (JP)
MATSUI MAKOTO (JP)
TAKEMOTO HIROYASU (JP)
NOMOTO TAKAHIRO (JP)
SUN XIAOHANG (JP)
OSAKAMA KAZUKI (JP)
HAMURA MIKA (JP)
INABA TAKANORI (JP)
NISHIYAMA NOBUHIRO (JP)
MATSUI MAKOTO (JP)
TAKEMOTO HIROYASU (JP)
NOMOTO TAKAHIRO (JP)
SUN XIAOHANG (JP)
Application Number:
PCT/JP2020/013600
Publication Date:
October 08, 2020
Filing Date:
March 26, 2020
Export Citation:
Assignee:
NOF CORP (JP)
TOKYO INST TECH (JP)
TOKYO INST TECH (JP)
International Classes:
C07K2/00; A61K38/18; A61K38/23; A61K38/27; A61K47/64; A61K47/65; C07K19/00
Domestic Patent References:
| WO2006088248A1 | 2006-08-24 | |||
| WO2005108463A2 | 2005-11-17 | |||
| WO2006088248A1 | 2006-08-24 |
Foreign References:
| CN106421806A | 2017-02-22 | |||
| JP2009527581A | 2009-07-30 | |||
| JP2007534324A | 2007-11-29 | |||
| JP2009527581A | 2009-07-30 | |||
| JP2014208786A | 2014-11-06 | |||
| JP2011079934A | 2011-04-21 | |||
| JP2019069450A | 2019-05-09 |
Other References:
LI, YACHAO AND XIANGHUI XU; XIAO ZHANG; YUNKUN LI; ZHIJUN ZHANG; ZHONGWEI GU: "Tumor-specific Multiple Stimuli-Activated Dendrimeric Nanoassemblies with Metabolic Blockade Surmount Chemotherapy Resistance", ACS NANO, vol. 11, no. 1, 24 January 2017 (2017-01-24), pages 416 - 429, XP055745932, DOI: 10.1021/acsnano.6b06161
VERONESE, FRANCE SCO M. ET AL.: "PEG-Doxorubicin Conjugates: Influence of Polymer Structure on Drug Release", IN VITRO CYTOTOXICITY, BIODISTRIBUTION, AND ANTITUMOR ACTIVITY, BIOCONJUGATE CHEMISTRY, vol. 16, no. 4, 1 July 2005 (2005-07-01), pages 775 - 784, XP055036563, DOI: 10.1021/bc040241m
RIVAS, PAULA LOPEZ, RANĐELOVIĆ IVAN, RAPOSO MOREIRA DIAS ANDRÉ ET AL.: "Synthesis and Biological Evaluation of Paclitaxel Conjugates Involving Linkers Cleavable by Lysosomal Enzymes and alpha v beta 3- Integrin Ligands for Tumor Targeting", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2018, no. 23, 22 June 2018 (2018-06-22), pages 2902 - 2909, XP055746758, DOI: 10.1002/ejoc.201800447
DANIEL G. RUDMANN ET AL., TOXICOL. PATHOL., vol. 41, 2013, pages 970 - 983
FRANCESCO M VERONESE ET AL., BIOCONJUGATE CHEM., vol. 16, 2005, pages 775 - 784
JIYUAN YANG ET AL., MARCOMOL. BIOSCI., vol. 10, no. 4, 2010, pages 445 - 454
YULIA VUGMEYSTERANG ET AL., BIOCONJUGATE CHEM., vol. 23, 2012, pages 1452 - 1462
KYTE JDOOLITTLE RF, J MOL BIOL, vol. 157, 1982, pages 105 - 132
HARRIS, J. M.: "Poly (Ethylene Glycol) Chemistry", 1992, PLENUM PRESS
HERMANSON, G. T: "Bioconjugate Techniques", 2013, ACADEMIC PRESS, article "Hermanson, G. T"
"PEGylated Protein Drugs: Basic Science and Clinical Applications", 2009, BIRKHAUSER
WUTS, P. G. M.GREENE, T. W: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
MARK, SONNY S., BIOCONJUGATE PROTOCOLS, STRATEGIES AND METHODS, 2011
See also references of EP 3950703A4
VERONESE, FRANCE SCO M. ET AL.: "PEG-Doxorubicin Conjugates: Influence of Polymer Structure on Drug Release", IN VITRO CYTOTOXICITY, BIODISTRIBUTION, AND ANTITUMOR ACTIVITY, BIOCONJUGATE CHEMISTRY, vol. 16, no. 4, 1 July 2005 (2005-07-01), pages 775 - 784, XP055036563, DOI: 10.1021/bc040241m
RIVAS, PAULA LOPEZ, RANĐELOVIĆ IVAN, RAPOSO MOREIRA DIAS ANDRÉ ET AL.: "Synthesis and Biological Evaluation of Paclitaxel Conjugates Involving Linkers Cleavable by Lysosomal Enzymes and alpha v beta 3- Integrin Ligands for Tumor Targeting", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2018, no. 23, 22 June 2018 (2018-06-22), pages 2902 - 2909, XP055746758, DOI: 10.1002/ejoc.201800447
DANIEL G. RUDMANN ET AL., TOXICOL. PATHOL., vol. 41, 2013, pages 970 - 983
FRANCESCO M VERONESE ET AL., BIOCONJUGATE CHEM., vol. 16, 2005, pages 775 - 784
JIYUAN YANG ET AL., MARCOMOL. BIOSCI., vol. 10, no. 4, 2010, pages 445 - 454
YULIA VUGMEYSTERANG ET AL., BIOCONJUGATE CHEM., vol. 23, 2012, pages 1452 - 1462
KYTE JDOOLITTLE RF, J MOL BIOL, vol. 157, 1982, pages 105 - 132
HARRIS, J. M.: "Poly (Ethylene Glycol) Chemistry", 1992, PLENUM PRESS
HERMANSON, G. T: "Bioconjugate Techniques", 2013, ACADEMIC PRESS, article "Hermanson, G. T"
"PEGylated Protein Drugs: Basic Science and Clinical Applications", 2009, BIRKHAUSER
WUTS, P. G. M.GREENE, T. W: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
MARK, SONNY S., BIOCONJUGATE PROTOCOLS, STRATEGIES AND METHODS, 2011
See also references of EP 3950703A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
Download PDF:
Previous Patent: BRANCHED AND DEGRADABLE POLYETHYLENE GLYCOL DERIVATIVE
Next Patent: TRANSPORT MANAGEMENT DEVICE AND TRANSPORT MANAGEMENT METHOD
Next Patent: TRANSPORT MANAGEMENT DEVICE AND TRANSPORT MANAGEMENT METHOD