Title:
BRANCHED AND DEGRADABLE POLYETHYLENE GLYCOL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2020/203625
Kind Code:
A1
Abstract:
The present invention provides a branched and degradable polyethylene glycol derivative represented by formula (1) that is to be used for modifying a bio-related substance and degraded in cells. (In the formula, each symbol is as defined in the description.)
Inventors:
YOSHIOKA HIROKI (JP)
OSAKAMA KAZUKI (JP)
HAMURA MIKA (JP)
INABA TAKANORI (JP)
NISHIYAMA NOBUHIRO (JP)
MATSUI MAKOTO (JP)
TAKEMOTO HIROYASU (JP)
NOMOTO TAKAHIRO (JP)
SUN XIAOHANG (JP)
OSAKAMA KAZUKI (JP)
HAMURA MIKA (JP)
INABA TAKANORI (JP)
NISHIYAMA NOBUHIRO (JP)
MATSUI MAKOTO (JP)
TAKEMOTO HIROYASU (JP)
NOMOTO TAKAHIRO (JP)
SUN XIAOHANG (JP)
Application Number:
PCT/JP2020/013598
Publication Date:
October 08, 2020
Filing Date:
March 26, 2020
Export Citation:
Assignee:
NOF CORP (JP)
TOKYO INST TECH (JP)
TOKYO INST TECH (JP)
International Classes:
C08G65/333; C08G81/00; C08L101/16
Domestic Patent References:
| WO2005108463A2 | 2005-11-17 | |||
| WO2006088248A1 | 2006-08-24 |
Foreign References:
| CN106421806A | 2017-02-22 | |||
| JP2013533217A | 2013-08-22 | |||
| JP2009527581W | ||||
| JP2014208786A | 2014-11-06 | |||
| JP2011079934A | 2011-04-21 | |||
| JP2019069449A | 2019-05-09 |
Other References:
YACHAO LI ET AL.: "Tumor-Specific Multiple Stimuli-Activated Dendrimeric Nanoassemblies with Metabolic Blockade Surmount Chemotherapy Resistance", ACS NANO, vol. 11, 2017, pages 416 - 429, XP055745932, DOI: 10.1021/acsnano.6b06161
VAN DER POLL, DEREK G.: "Design, Synthesis, and Biological Evaluation of a Robust, Biodegradable Dendrimer", BIOCONJUGATE CHEMISTRY, vol. 21, no. 4, 2010, pages 764 - 773, XP055358812, DOI: 10.1021/bc900553n
WENCHUAN SHE: "The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron-doxorubicin conjugates for cancer therapy", BIOMATERIALS, vol. 34, no. 5, 2013, pages 1613 - 1623, XP028960621, DOI: 10.1016/j.biomaterials.2012.11.007
DANIEL G. RUDMANN ET AL., TOXICOL. PATHOL., vol. 41, 2013, pages 970 - 983
BIOCONJUGATE CHEM., vol. 16, 2005, pages 775 - 784
JIYUAN YANG ET AL., MARCOMOL. BIOSCI., vol. 10, no. 4, 2010, pages 445 - 454
YULIA VUGMEYSTERANG ET AL., BIOCONJUGATE CHEM., vol. 23, 2012, pages 1452 - 1462
KYTE JDOOLITTLE RF, J MOL BIOL, vol. 157, 1982, pages 105 - 132
HARRIS, J. M. POLY: "Ethylene Glycol) Chemistry", 1992, PLENUM PRESS
HERMANSON, G. T.: "Bioconjugate Techniques", 2008, ACADEMIC PRESS
"PEGylated Protein Drugs: Basic Science and Clinical Applications", 2009, BIRKHAUSER
WUTS, P. G. M.GREENE, T. W.: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
See also references of EP 3950776A4
VAN DER POLL, DEREK G.: "Design, Synthesis, and Biological Evaluation of a Robust, Biodegradable Dendrimer", BIOCONJUGATE CHEMISTRY, vol. 21, no. 4, 2010, pages 764 - 773, XP055358812, DOI: 10.1021/bc900553n
WENCHUAN SHE: "The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron-doxorubicin conjugates for cancer therapy", BIOMATERIALS, vol. 34, no. 5, 2013, pages 1613 - 1623, XP028960621, DOI: 10.1016/j.biomaterials.2012.11.007
DANIEL G. RUDMANN ET AL., TOXICOL. PATHOL., vol. 41, 2013, pages 970 - 983
BIOCONJUGATE CHEM., vol. 16, 2005, pages 775 - 784
JIYUAN YANG ET AL., MARCOMOL. BIOSCI., vol. 10, no. 4, 2010, pages 445 - 454
YULIA VUGMEYSTERANG ET AL., BIOCONJUGATE CHEM., vol. 23, 2012, pages 1452 - 1462
KYTE JDOOLITTLE RF, J MOL BIOL, vol. 157, 1982, pages 105 - 132
HARRIS, J. M. POLY: "Ethylene Glycol) Chemistry", 1992, PLENUM PRESS
HERMANSON, G. T.: "Bioconjugate Techniques", 2008, ACADEMIC PRESS
"PEGylated Protein Drugs: Basic Science and Clinical Applications", 2009, BIRKHAUSER
WUTS, P. G. M.GREENE, T. W.: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
See also references of EP 3950776A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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