Title:
BRANCHED POLYGLYCOL EPOXY DERIVATIVE CROSS-LINKED SODIUM HYALURONATE GEL, PREPARATION THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/001472
Kind Code:
A1
Abstract:
A branched polyglycol epoxy derivative cross-linked sodium hyaluronate gel, preparation therefor, and an application thereof. A cross-linking agent used in the prepared cross-linked sodium hyaluronate gel is a polyglycol epoxy derivative. There is a plurality of ether bonds present in the molecules of the polyglycol epoxy derivative, such that more hydrogen bonds are present in the gel system, thereby enhancing the stability of the gel. Moreover, due to the special spatial structure of the branched polyglycol derivative, the winding spatial structure of the prepared gel is more complex, such that the prepared gel is more stable. Because the related branched polyglycol epoxy derivative is a single molecular weight compound, the prepared gel product has good batch stability.
Inventors:
WEI ZHEN (CN)
LIN MEINA (CN)
ZHAO XUAN (CN)
LIN MEINA (CN)
ZHAO XUAN (CN)
Application Number:
PCT/CN2018/093133
Publication Date:
January 03, 2019
Filing Date:
June 27, 2018
Export Citation:
Assignee:
JENKEM TECH CO LTD BEIJING (CN)
International Classes:
C08J3/075; A61L27/20; A61L27/50; C07D303/30; C08G59/04; C08J3/24; C08L5/08
Foreign References:
| CN106589424A | 2017-04-26 | |||
| US20040096507A1 | 2004-05-20 | |||
| CN101724144A | 2010-06-09 | |||
| CN106167549A | 2016-11-30 | |||
| CN103974722A | 2014-08-06 | |||
| CN103360633A | 2013-10-23 |
Other References:
TEODORESCU, M. ET AL.: "Novel Hydrogels from Diepoxy-terminated Poly(ethylene glycol)s and Aliphatic Primary Diamines: Synthesis and Equilibrium Swelling Studies", POLYM. ADV. TECHNOL., 9 January 2009 (2009-01-09), pages 907 - 915, XP055511398
Attorney, Agent or Firm:
BEIJING BRIGHT IP AGENCY CO., LTD. (CN)
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