Title:
A BUILDING BLOCK CAPABLE OF FUNCTIONAL ENTITY TRANSFER TO NUCLEOPHIL
Document Type and Number:
WIPO Patent Application WO2003078627
Kind Code:
A3
Abstract:
A building block having the dual capabilities of transferring the genetic information e.g. by recognising an encoding element and transferring a functional entity to a recipient reactive group is diclosed. The building block can be designed with an adjustable transferability taking into account the components of the building block. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.
Inventors:
GOULIAEV ALEX HAAHR (DK)
PEDERSEN HENRIK (DK)
THISTED THOMAS (DK)
LUNDORF MIKKEL DYBRO (DK)
SAMS CHRISTIAN (DK)
FRANCH THOMAS (DK)
HUSEMOEN GITTE NYSTRUP (DK)
HO JUSTIN (DK)
PEDERSEN HENRIK (DK)
THISTED THOMAS (DK)
LUNDORF MIKKEL DYBRO (DK)
SAMS CHRISTIAN (DK)
FRANCH THOMAS (DK)
HUSEMOEN GITTE NYSTRUP (DK)
HO JUSTIN (DK)
Application Number:
PCT/DK2003/000177
Publication Date:
December 31, 2003
Filing Date:
March 14, 2003
Export Citation:
Assignee:
NUEVOLUTION AS (DK)
GOULIAEV ALEX HAAHR (DK)
PEDERSEN HENRIK (DK)
THISTED THOMAS (DK)
LUNDORF MIKKEL DYBRO (DK)
SAMS CHRISTIAN (DK)
FRANCH THOMAS (DK)
HUSEMOEN GITTE NYSTRUP (DK)
HO JUSTIN (DK)
GOULIAEV ALEX HAAHR (DK)
PEDERSEN HENRIK (DK)
THISTED THOMAS (DK)
LUNDORF MIKKEL DYBRO (DK)
SAMS CHRISTIAN (DK)
FRANCH THOMAS (DK)
HUSEMOEN GITTE NYSTRUP (DK)
HO JUSTIN (DK)
International Classes:
C07B61/00; C07D405/04; C07F9/6558; C07F9/6561; C07H21/00; C07H21/02; C07H23/00; C12N15/10; C12P19/34; (IPC1-7): C07H21/00
Other References:
WALDER J A ET AL: "COMPLEMENTARY CARRIER PEPTIDE SYNTHESIS: GENERAL STRATEGY AND IMPLICATIONS FOR PREBIOTIC ORIGIN OF PEPTIDE SYNTHESIS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 76, no. 1, January 1979 (1979-01-01), pages 51 - 55, XP000857351, ISSN: 0027-8424
BRUICK R K ET AL: "TEMPLATE-DIRECTED LIGATION OF PEPTIDES TO OLIGONUCLEOTIDES", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 3, no. 1, January 1996 (1996-01-01), pages 49 - 56, XP000856876, ISSN: 1074-5521
BRUICK R K ET AL: "TEMPLATE-DIRECTED LIGATION OF PEPTIDES TO OLIGONUCLEOTIDES", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 3, no. 1, January 1996 (1996-01-01), pages 49 - 56, XP000856876, ISSN: 1074-5521
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