Title:
C-MYC CODING REGION DETERMINANT-BINDING PROTEIN (CRD-BP)
Document Type and Number:
WIPO Patent Application WO1999046594
Kind Code:
A3
Abstract:
A method of diagnosing the presence or absence of cancer in a human patient is disclosed. In one embodiment, this method comprises the steps of examining patient tissue for the CRD-BP expression levels and comparing that expression level with control levels. The present invention is also a method of inhibiting cancer cell growth comprising the step of eliminating or lowering the level of functional CRD-BP in the cancerous tissues.
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Inventors:
ROSS JEFFREY
Application Number:
PCT/US1999/004897
Publication Date:
December 09, 1999
Filing Date:
March 05, 1999
Export Citation:
Assignee:
WISCONSIN ALUMNI RES FOUND (US)
International Classes:
A61K39/395; A61P35/00; G01N33/53; C07K16/28; C12Q1/68; G01N33/574; G01N33/68; (IPC1-7): G01N33/574; C12Q1/68
Other References:
LEEDS, P. ET AL.: "Developmental regulation of CRD-BP, an RNA-binding protein that stabilizes c-myc mRNA in vitro", ONCOGENE, vol. 14, no. 11, 20 March 1997 (1997-03-20), pages 1279 - 1286, XP002118533
MÜLLER-PILLASCH, F. ET AL.: "Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein", ONCOGENE, vol. 14, no. 22, 5 June 1997 (1997-06-05), pages 2729 - 2733, XP002118534
DOYLE, G.A.R. ET AL.: "The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins", NUCLEIC ACID RESEARCH, vol. 26, no. 22, 1998, pages 5036 - 5044, XP002118535
MÜLLER-PILLASCH, F. ET AL.: "Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein", ONCOGENE, vol. 14, no. 22, 5 June 1997 (1997-06-05), pages 2729 - 2733, XP002118534
DOYLE, G.A.R. ET AL.: "The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins", NUCLEIC ACID RESEARCH, vol. 26, no. 22, 1998, pages 5036 - 5044, XP002118535
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