Title:
CELL LINE FOR THE EXPRESSION OF AN alpha 2 delta 2 CALCIUM CHANNEL SUBUNIT
Document Type and Number:
WIPO Patent Application WO2001088101
Kind Code:
A3
Abstract:
Described is a method for determining the binding ability of a compound to bind to an alpha 2 delta 2 subunit of a calcium channel comprising: providing an alpha 2 delta 2 subunit of a calcium channel, contacting the subunit with the compound, and determining the binding ability of the compound to bind to the subunit.
Inventors:
SU TI-ZHI (US)
Application Number:
PCT/US2001/014799
Publication Date:
August 08, 2002
Filing Date:
May 08, 2001
Export Citation:
Assignee:
WARNER LAMBERT CO (US)
SU TI-ZHI (US)
SU TI-ZHI (US)
International Classes:
G01N33/50; A61K31/195; C07K14/705; C12N5/10; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; G01N33/68; G01N33/94; (IPC1-7): C12N5/06; C07C229/28; C07C255/23; C07D257/04; C07K14/705; G01N33/50; G01N33/68
Domestic Patent References:
| WO1996039512A2 | 1996-12-12 | |||
| WO1999008670A1 | 1999-02-25 |
Other References:
GAO BONING ET AL: "Functional properties of a new voltage-dependent calcium channel alpha2delta auxiliary subunit gene (CACNA2D2).", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 16, 21 April 2000 (2000-04-21), pages 12237 - 12242, XP002198181, ISSN: 0021-9258
KLUGBAUER N ET AL: "MOLECULAR DIVERSITY OF THE CALCIUM CHANNEL ALPHA 2 DELTA SUBUNIT", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 19, no. 2, 15 January 1999 (1999-01-15), pages 684 - 691, XP000886459, ISSN: 0270-6474
GEE N S ET AL: "THE NOVEL ANTICONVULSANT DRUG, GABAPENTIN (NEURONTIN), BINDS TO THEALPHA2DELTA SUBUNIT OF A CALCIUM CHANNEL", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 10, 8 March 1996 (1996-03-08), pages 5768 - 5776, XP002022221, ISSN: 0021-9258
SUMAN-CHAUHAN N ET AL: "Characterisation of [3H]gabapentin binding to a novel site in rat brain: Homogenate binding studies", EUROPEAN JOURNAL OF PHARMACOLOGY. MOLECULAR PHARMACOLOGY SECTION, ELSEVIER SCIENCE BV, AMSTERDAM, NL, vol. 244, no. 3, 1993, pages 293 - 301, XP002096653, ISSN: 0922-4106
SU T ET AL: "Human alpha2beta2 subunit of calcium channel: a novel gabapentin binding protein in brain.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 26, no. 1-2, November 2000 (2000-11-01), 30th Annual Meeting of the Society of Neuroscience;New Orleans, LA, USA; November 04-09, 2000, pages Abstract No. - 40.20, XP001068225, ISSN: 0190-5295
KLUGBAUER N ET AL: "MOLECULAR DIVERSITY OF THE CALCIUM CHANNEL ALPHA 2 DELTA SUBUNIT", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 19, no. 2, 15 January 1999 (1999-01-15), pages 684 - 691, XP000886459, ISSN: 0270-6474
GEE N S ET AL: "THE NOVEL ANTICONVULSANT DRUG, GABAPENTIN (NEURONTIN), BINDS TO THEALPHA2DELTA SUBUNIT OF A CALCIUM CHANNEL", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 10, 8 March 1996 (1996-03-08), pages 5768 - 5776, XP002022221, ISSN: 0021-9258
SUMAN-CHAUHAN N ET AL: "Characterisation of [3H]gabapentin binding to a novel site in rat brain: Homogenate binding studies", EUROPEAN JOURNAL OF PHARMACOLOGY. MOLECULAR PHARMACOLOGY SECTION, ELSEVIER SCIENCE BV, AMSTERDAM, NL, vol. 244, no. 3, 1993, pages 293 - 301, XP002096653, ISSN: 0922-4106
SU T ET AL: "Human alpha2beta2 subunit of calcium channel: a novel gabapentin binding protein in brain.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 26, no. 1-2, November 2000 (2000-11-01), 30th Annual Meeting of the Society of Neuroscience;New Orleans, LA, USA; November 04-09, 2000, pages Abstract No. - 40.20, XP001068225, ISSN: 0190-5295
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