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Title:
NOVEL METHOD OF INDUCING THE DIFFERENTIATION OF EMBRYONIC STEM CELLS INTO ECTODERMAL CELLS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2001/088100
Kind Code:
A1
Abstract:
A method of inducing the differentiation of embryonic stem cells into ectodermal cells which involves the step of culturing the embryonic stem cells in a non-agglutinated state, and a method of inducing the differentiation of embryonic stem cells into cells originating in ectodermal cells which involves the step of culturing the embryonic stem cells in a non-agglutinated state; a medium and a medium supernatant to be used in these methods; a differentiation inducer to be used in these methods; stroma cells having an activity of inducing the differentiation in these methods or a factor originating therein; an antibody specifically recognizing these stroma cells; an antigen recognizing this antibody; cells induced by the above methods; a method of evaluating a substance relating to the regulation of the differentiation process from embryonic stem cells into ectodermal cells or cells originating in ectodermal cells by performing the above methods, and a screening method; and drugs containing the above-described stroma cells or the factor originating therein, the above-described antibody, the above-described antigen or the above-described cells.

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Inventors:
SASAI YOSHIKI (JP)
NISHIKAWA SHIN-ICHI
Application Number:
PCT/JP2001/004080
Publication Date:
November 22, 2001
Filing Date:
May 16, 2001
Export Citation:
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Assignee:
KYOWA HAKKO KOGYO KK (JP)
SASAI YOSHIKI (JP)
International Classes:
A61P17/00; A61P25/00; A61P25/28; C07K16/18; C12N5/071; C12N5/0793; C12P21/08; (IPC1-7): C12N5/06; A61K35/30; A61K35/36; A61K35/48; A61P17/00; A61P25/00; A61P25/28; C07K16/18; C12P21/08; C12Q1/02; G01N33/15; G01N33/50
Other References:
WILSON P.A. ET AL.: "Induction of epidermis and inhibition of neural fate by Bmp-4", NATURE, vol. 376, no. 6538, 1995, pages 331 - 333, XP002944766
KODAMA H. ET AL.: "MC3T3-G2/PA6 preadipocytes support in vitro proliferation of hemapoietic stem cells through a mechanism different from that of interleukin 3", J. CELL PHYSIOL., vol. 129, no. 1, 1986, pages 20 - 26, XP002944767
KAWASAKI H. ET AL.: "Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity", NEURON., vol. 28, no. 1, October 2000 (2000-10-01), pages 31 - 40, XP002944768
NAKANO T. ET AL.: "In vitro development of hematopoietic system from mouse embryonic stem cells: a new approach for embryonic hematopoiesis", INT. J. HEMATOL., vol. 65, no. 1, 1996, pages 1 - 8, XP002944769
VAN INZEN W.G. ET AL.: "Neuronal differentiation of embryonic stem cells", BIOCHIM. BIOPHYS. ACTA, vol. 1312, no. 1, 1996, pages 21 - 26, XP002944770
KIYOSHI KOMATSU ET AL.: "Bunsan baiyou wo mochiita embryonic stem (ES) cell no in vitro shinkei bunka to gap ketsugou saiboukan communication no kenkyuu", SAPPORO ISHI, vol. 67, no. 1-2, 1998, pages 11 - 22, XP002944771
See also references of EP 1302533A4
Attorney, Agent or Firm:
Oguri, Shohei (28th Floor ARK Mori Building 12-32 Akasaka 1-chome Minato-ku, Tokyo, JP)
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