Title:
CAMPTOTHECIN DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/022167
Kind Code:
A1
Abstract:
The present invention provides a novel camptothecin derivative compound, a pharmaceutically acceptable salt, a stereoisomer, or a prodrug thereof, and a method for preparing same and use thereof. The compound has a structure represented by formula (I) and has good anti-cancer activity.
Inventors:
HUANG YUNSHENG (CN)
REN BINGTAO (CN)
FAN WANGE (CN)
LI YAOWU (CN)
WANG XIAOBEI (CN)
LI DELIANG (CN)
DAI QING (CN)
ZHANG LAIGUO (CN)
ZHANG SHIYI (CN)
XU ZHENJIANG (CN)
REN BINGTAO (CN)
FAN WANGE (CN)
LI YAOWU (CN)
WANG XIAOBEI (CN)
LI DELIANG (CN)
DAI QING (CN)
ZHANG LAIGUO (CN)
ZHANG SHIYI (CN)
XU ZHENJIANG (CN)
Application Number:
PCT/CN2023/107935
Publication Date:
February 01, 2024
Filing Date:
July 18, 2023
Export Citation:
Assignee:
HANGZHOU ADCORIS BIOPHARMA CO LTD (CN)
International Classes:
C07D491/22; A61K31/4745; A61K31/496; A61K31/5365; A61K31/5377; A61K47/68; A61P35/00; C07D498/22; C07D519/00
Domestic Patent References:
| WO2022204184A1 | 2022-09-29 | |||
| WO2022155347A1 | 2022-07-21 | |||
| WO2021212638A1 | 2021-10-28 |
Foreign References:
| CN116478174A | 2023-07-25 | |||
| CN1034724A | 1989-08-16 | |||
| CN101951914A | 2011-01-19 | |||
| CN102659800A | 2012-09-12 |
Other References:
WANG XIANGYANG, WANG LI-KAI, KINGSBURY WILLIAM D., JOHNSON RANDALL K., HECHT SIDNEY M.: "Differential Effects of Camptothecin Derivatives on Topoisomerase I-Mediated DNA Structure Modification", BIOCHEMISTRY, vol. 37, no. 26, 1 June 1998 (1998-06-01), pages 9399 - 9408, XP093132541, ISSN: 0006-2960, DOI: 10.1021/bi980451k
Attorney, Agent or Firm:
MERITS IP LTD. (CN)
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