Title:
CANCER ASSESSMENT DEVICE, CANCER ASSESSMENT METHOD, AND PROGRAM
Document Type and Number:
WIPO Patent Application WO/2021/080007
Kind Code:
A1
Abstract:
This cancer assessment device comprises: an irradiation unit that irradiates tissue with excitation light; a third high-frequency image acquisition unit that acquires a third high-frequency image of the tissue on the basis of light generated through third high-frequency generation occurring due to interaction between the tissue and the excitation light; and a cancer tissue assessment unit that assesses the possibility that the tissue is cancer tissue on the basis of the state of cell nuclei in the third high-frequency image.
Inventors:
ISHII MASARU (JP)
MATSUI TAKAHIRO (JP)
TAMOTO RYO (JP)
IWASA AKIO (JP)
MIMURA MASAFUMI (JP)
MATSUI TAKAHIRO (JP)
TAMOTO RYO (JP)
IWASA AKIO (JP)
MIMURA MASAFUMI (JP)
Application Number:
PCT/JP2020/039977
Publication Date:
April 29, 2021
Filing Date:
October 23, 2020
Export Citation:
Assignee:
UNIV OSAKA (JP)
NIKON CORP (JP)
NIKON CORP (JP)
International Classes:
G01N21/64; G01N33/48; G06T7/00
Domestic Patent References:
| WO2017200066A1 | 2017-11-23 |
Foreign References:
| CN109299679A | 2019-02-01 | |||
| JP2019192469A | 2019-10-31 | |||
| JP2019192470A | 2019-10-31 |
Other References:
ADUR JAVIER, PELEGATI VITOR B., DE THOMAZ ANDRE A., BARATTI MARIANA O., ALMEIDA DIOGO B., ANDRADE L. A. L. A., BOTTCHER-LUIZ FÁTIM: "Optical Biomarkers of Serous and Mucinous Human Ovarian Tumor Assessed with Nonlinear Optics Microscopies", PLOS ONE, vol. 7, no. 10, 2012, pages e47007-1 - e47007-13, XP055820642, DOI: 10.1371/journal.pone.0047007
TOKARZ DANIELLE, CISEK RICHARD, JOSEPH ARIANA, GOLARAEI AHMAD, MIRSANAYE KAMDIN, KROUGLOV SERGUEI, ASA SYLVIA L., WILSON BRIAN C.,: "Characterization of Pancreatic Cancer Tissue Using Multiphoton Excitation Fluorescence and Polarization-Sensitive Harmonic Generation Microscopy", FRONTIERS IN ONCOLOGY, vol. 9, no. 272, 17 April 2019 (2019-04-17), pages 1 - 10, XP055820646, DOI: 10.3389/fonc.2019.00272
GAVGIOTAKI, EVANGELIA, TSAFAS, VASSILIS, BOVASIANOS, SAVVAS, AGELAKI, SOFIA, GEORGOULIAS, VASSILIS, ET AL.: "Nonlinear imaging of female breast tissue biopsies", PROCEEDINGS OF SPIE, vol. 11076, 22 July 2019 (2019-07-22), pages 110760I-1 - 110760I-6, XP060123570
AMBEKAR RAGHU, LAU TUNG-YUEN, WALSH MICHAEL, BHARGAVA ROHIT, TOUSSAINT KIMANI C.: "Quantifying collagen structure in breast biopsies using second-harmonic generation imaging", BIOMEDICAL OPTICS EXPRESS, vol. 3, no. 9, 2012, pages 2021 - 2035, XP055820653
LIN, JIAN, TEH, SENGKHOON, ZHENG, WEI, WANG, ZI, HUANG, ZHIWEI: "Study of acetowhitening mechanisms in live mammalian cells with labelfree subcellular-level multimodal nonlinear optical microscopy", PROCEEDING OF SPIE, vol. 9329, 2015, pages 93290T-1 - 93290T-7, XP060049194
SHEIKHZADEH FAHIME; WARD RABAB K; CARRARO ANITA; CHEN ZHAOYANG; VAN NIEKERK DIRK; MACAULAY CALUM; FOLLEN MICHELE; LANE PIERRE; GUI: "Confocal fluorescence microscopy for detection of cervical preneoplastic lesions", PROCEEDINGS OF SPIE, vol. 9420, 2015, pages 942009-1 - 942009-6, XP060051547
ALI, MEHBOB ET AL.: "Artificial neural network based screening of cervical cancer using a hierarchical modular neural network architecture (HMNNA) and novel benchmark uterine cervix cancer database", NEURAL COMPUT & APPLIC, vol. 31, 2019, pages 2979 - 2993, XP036850367, DOI: 10.1007/s00521-017-3246-7
See also references of EP 4050326A4
TOKARZ DANIELLE, CISEK RICHARD, JOSEPH ARIANA, GOLARAEI AHMAD, MIRSANAYE KAMDIN, KROUGLOV SERGUEI, ASA SYLVIA L., WILSON BRIAN C.,: "Characterization of Pancreatic Cancer Tissue Using Multiphoton Excitation Fluorescence and Polarization-Sensitive Harmonic Generation Microscopy", FRONTIERS IN ONCOLOGY, vol. 9, no. 272, 17 April 2019 (2019-04-17), pages 1 - 10, XP055820646, DOI: 10.3389/fonc.2019.00272
GAVGIOTAKI, EVANGELIA, TSAFAS, VASSILIS, BOVASIANOS, SAVVAS, AGELAKI, SOFIA, GEORGOULIAS, VASSILIS, ET AL.: "Nonlinear imaging of female breast tissue biopsies", PROCEEDINGS OF SPIE, vol. 11076, 22 July 2019 (2019-07-22), pages 110760I-1 - 110760I-6, XP060123570
AMBEKAR RAGHU, LAU TUNG-YUEN, WALSH MICHAEL, BHARGAVA ROHIT, TOUSSAINT KIMANI C.: "Quantifying collagen structure in breast biopsies using second-harmonic generation imaging", BIOMEDICAL OPTICS EXPRESS, vol. 3, no. 9, 2012, pages 2021 - 2035, XP055820653
LIN, JIAN, TEH, SENGKHOON, ZHENG, WEI, WANG, ZI, HUANG, ZHIWEI: "Study of acetowhitening mechanisms in live mammalian cells with labelfree subcellular-level multimodal nonlinear optical microscopy", PROCEEDING OF SPIE, vol. 9329, 2015, pages 93290T-1 - 93290T-7, XP060049194
SHEIKHZADEH FAHIME; WARD RABAB K; CARRARO ANITA; CHEN ZHAOYANG; VAN NIEKERK DIRK; MACAULAY CALUM; FOLLEN MICHELE; LANE PIERRE; GUI: "Confocal fluorescence microscopy for detection of cervical preneoplastic lesions", PROCEEDINGS OF SPIE, vol. 9420, 2015, pages 942009-1 - 942009-6, XP060051547
ALI, MEHBOB ET AL.: "Artificial neural network based screening of cervical cancer using a hierarchical modular neural network architecture (HMNNA) and novel benchmark uterine cervix cancer database", NEURAL COMPUT & APPLIC, vol. 31, 2019, pages 2979 - 2993, XP036850367, DOI: 10.1007/s00521-017-3246-7
See also references of EP 4050326A4
Attorney, Agent or Firm:
NISHIZAWA Kazuyoshi et al. (JP)
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