Title:
CANNABIDIOL DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/103733
Kind Code:
A1
Abstract:
Disclosed are a cannabidiol derivative, and a preparation method therefor and the use thereof, and in particular the use thereof in the prevention and treatment of a nervous system disease (such as epilepsy and Parkinson's disease). The cannabidiol derivative is obtained by means of screening from a series of synthetic derivatives, and animal test results show that the compounds can effectively shorten the epileptic seizure duration of an experimental animal, improves the epileptic seizure symptoms of the experimental animal, reduces the balance beam score of the Parkinson's model animal, increases the dopamine level and the tyrosine hydroxylase (TH) cell positivity in the substantia nigra (SubN), can be used for drug development and research on various diseases such as epilepsy and Parkinson's disease, and has a better application value.
Inventors:
WANG SHUBIN (CN)
DU YESONG (CN)
ZHANG PINGPING (CN)
DU YESONG (CN)
ZHANG PINGPING (CN)
Application Number:
PCT/CN2022/132572
Publication Date:
June 15, 2023
Filing Date:
November 17, 2022
Export Citation:
Assignee:
DEYI PHARMARMACEUTICAL LTD (CN)
International Classes:
C07C271/44; A61K31/265; A61K31/27; A61P25/04; A61P25/08; A61P29/00; C07C47/277; C07C219/04; C07C229/12
Domestic Patent References:
| WO2022213931A1 | 2022-10-13 | |||
| WO2021062231A2 | 2021-04-01 | |||
| WO2017132526A1 | 2017-08-03 | |||
| WO2021000053A1 | 2021-01-07 | |||
| WO2021007662A1 | 2021-01-21 |
Foreign References:
| CN109311838A | 2019-02-05 | |||
| CN101815697A | 2010-08-25 |
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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