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Title:
CANNABIDIOL DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/103734
Kind Code:
A1
Abstract:
Disclosed in the present invention are a cannabidiol derivative, a preparation method therefor and an application thereof, particularly an application in preventing and treating nervous system diseases (such as Parkinson's disease). The cannabidiol derivative is obtained by screening from a series of synthetic derivatives. An animal testing result shows that the cannabidiol derivative can reduce the balance beam score of a Parkinson's model animal and improve the dopamine level and the tyrosine hydroxylase (TH) cell positive rate in substantia nigra (SubN), can be used for drug development and research of various diseases such as epilepsy and Parkinson's disease, and has better application value.

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Inventors:
WANG SHUBIN (CN)
DU YESONG (CN)
ZHANG PINGPING (CN)
Application Number:
PCT/CN2022/132587
Publication Date:
June 15, 2023
Filing Date:
November 17, 2022
Export Citation:
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Assignee:
DEYI PHARMARMACEUTICAL LTD (CN)
International Classes:
C07C69/017; A61K31/05; A61P1/08; C07C219/04; C07C229/12; C07C271/44
Domestic Patent References:
WO2021127667A12021-06-24
WO2018096504A12018-05-31
WO1999053917A11999-10-28
WO2011026144A12011-03-03
WO2017132526A12017-08-03
Foreign References:
CN107072278A2017-08-18
CN109311838A2019-02-05
Other References:
HANDRICK G. RICHARD, RAZDAN RAJ K, ULISS DAVID B, DALZELL HALDEAN C, BOGER ELIAHU: "Hashish. 20. Synthesis of (.+-.)-.DELTA.1- and .DELTA.6-3,4-cis-cannabidiols and their isomerization by acid catalysis", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 42, no. 15, 1 July 1977 (1977-07-01), pages 2563 - 2568, XP093071539, ISSN: 0022-3263, DOI: 10.1021/jo00435a007
DATABASE Registry 1 October 2020 (2020-10-01), ANONYMOUS : "INDEX NAME NOT YET ASSIGNED", XP093071543, retrieved from STN Database accession no. 2488717-92-4
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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