Title:
CARBONIC ANHYDRASE IX-TARGETING RADIOACTIVE DIAGNOSTIC AND THERAPEUTIC MEDICAMENT AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2023/155454
Kind Code:
A1
Abstract:
The present invention relates to a carbonic anhydrase IX-targeting radioactive diagnostic and therapeutic medicament and a method for preparing same, and in particular, relates to a compound represented by formula (I), or a pharmaceutically acceptable salt, ester or solvate thereof. The compound can be used for diagnosing and/or treating one or more tumors, cancers, or cells expressing carbonic anhydrase IX.
More Like This:
| WO/2023/240135 | BIFUNCTIONAL CHELATORS AND CONJUGATES |
| JP4541696 | Solid phase electrophile fluorination |
Inventors:
FANG PENG (CN)
YU SHANYOU (CN)
ZHU WENJIA (CN)
HUO LI (CN)
YAN CHENGLONG (CN)
ENG WAI-SI (CN)
YU SHANYOU (CN)
ZHU WENJIA (CN)
HUO LI (CN)
YAN CHENGLONG (CN)
ENG WAI-SI (CN)
Application Number:
PCT/CN2022/125512
Publication Date:
August 24, 2023
Filing Date:
October 14, 2022
Export Citation:
Assignee:
NORROY BIOSCIENCE CO LTD (CN)
International Classes:
A61K51/04; A61K49/10; A61P35/00; C07D417/12
Domestic Patent References:
| WO2015114171A1 | 2015-08-06 | |||
| WO2018154517A1 | 2018-08-30 | |||
| WO2016196628A1 | 2016-12-08 |
Foreign References:
| CN109476655A | 2019-03-15 | |||
| US20210154334A1 | 2021-05-27 |
Other References:
CAZZAMALLI, S. ET AL.,: "Acetazolamide Serves as Selective Delivery Vehicle for Dipeptide-Linked Drugs to Renal Cell Carcinoma,", MOLECULAR CANCER THERAPEUTICS,, vol. 15, no. 12, 1 December 2016 (2016-12-01), XP055456478, DOI: 10.1158/1535-7163.MCT-16-0283
KRALL NIKOLAUS, PRETTO FRANCESCA, MATTARELLA MARTIN, MÜLLER CRISTINA, NERI DARIO: "A 99m Tc-Labeled Ligand of Carbonic Anhydrase IX Selectively Targets Renal Cell Carcinoma In Vivo", THE JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, US, vol. 57, no. 6, 1 June 2016 (2016-06-01), US , pages 943 - 949, XP093085133, ISSN: 0161-5505, DOI: 10.2967/jnumed.115.170514
PELLEGRINO CHRISTIAN, FAVALLI NICHOLAS, SANDHOLZER MICHAEL, VOLTA LAURA, BASSI GABRIELE, MILLUL JACOPO, CAZZAMALLI SAMUELE, MATASC: "Impact of Ligand Size and Conjugation Chemistry on the Performance of Universal Chimeric Antigen Receptor T-Cells for Tumor Killing", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 31, no. 7, 15 July 2020 (2020-07-15), US , pages 1775 - 1783, XP055812821, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.0c00258
WICHERT, M. ET AL.,: "Dual-Display of Small Molecules Enables the Discovery of Ligand Pairs and Facilitates Affinity Maturation,", NATURE CHEMISTRY,, vol. 7, no. 3, 26 January 2015 (2015-01-26), XP055184296, DOI: 10.1038/nchem.2158
CHEN KUO-TING, NGUYEN KEVIN, IERITANO CHRISTIAN, GAO FENG, SEIMBILLE YANN: "A Flexible Synthesis of 68Ga-Labeled Carbonic Anhydrase IX (CAIX)-Targeted Molecules via CBT/1,2-Aminothiol Click Reaction", MOLECULES, vol. 24, no. 1, 21 December 2018 (2018-12-21), pages 23, XP093085135, DOI: 10.3390/molecules24010023
KRALL NIKOLAUS, PRETTO FRANCESCA, MATTARELLA MARTIN, MÜLLER CRISTINA, NERI DARIO: "A 99m Tc-Labeled Ligand of Carbonic Anhydrase IX Selectively Targets Renal Cell Carcinoma In Vivo", THE JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, US, vol. 57, no. 6, 1 June 2016 (2016-06-01), US , pages 943 - 949, XP093085133, ISSN: 0161-5505, DOI: 10.2967/jnumed.115.170514
PELLEGRINO CHRISTIAN, FAVALLI NICHOLAS, SANDHOLZER MICHAEL, VOLTA LAURA, BASSI GABRIELE, MILLUL JACOPO, CAZZAMALLI SAMUELE, MATASC: "Impact of Ligand Size and Conjugation Chemistry on the Performance of Universal Chimeric Antigen Receptor T-Cells for Tumor Killing", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 31, no. 7, 15 July 2020 (2020-07-15), US , pages 1775 - 1783, XP055812821, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.0c00258
WICHERT, M. ET AL.,: "Dual-Display of Small Molecules Enables the Discovery of Ligand Pairs and Facilitates Affinity Maturation,", NATURE CHEMISTRY,, vol. 7, no. 3, 26 January 2015 (2015-01-26), XP055184296, DOI: 10.1038/nchem.2158
CHEN KUO-TING, NGUYEN KEVIN, IERITANO CHRISTIAN, GAO FENG, SEIMBILLE YANN: "A Flexible Synthesis of 68Ga-Labeled Carbonic Anhydrase IX (CAIX)-Targeted Molecules via CBT/1,2-Aminothiol Click Reaction", MOLECULES, vol. 24, no. 1, 21 December 2018 (2018-12-21), pages 23, XP093085135, DOI: 10.3390/molecules24010023
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
Download PDF: