CARBOXYFULLERENES AND METHODS OF USE THEREOF

Title:

CARBOXYFULLERENES AND METHODS OF USE THEREOF

Document Type and Number:

WIPO Patent Application WO2003072802

Kind Code:

A3

Abstract:

The instant invention is a method for increasing a metazoan's lifespan, comprising administering a carboxylated derivative of a C60 fullerene. The instant invention further is a process for extending a metazoan's lifespan by administering a superoxide dismutase-mimetic as well as a composition comprising a superoxide dismutase-mimetic. Further, the instant invention comprises a pharmaceutical composition comprising carboxyfullerenes having x pairs of adjacent carbon atoms bonded to two carbons of the C60 sphere wherein said adjacent carbon atom is further bonded to two groups of the general formula -COOH and -R, wherein R is independently selected from the group consisting of -COOH and -H, and wherein x is at least 1. A further embodiment is a non-metal containing composition which can catalytically eliminate two biologically reactive species. Another embodiment is a method of enhancing elimination of reactive oxygen species in eukaryotic cells by contacting cells with a superoxide dismutase mimetic.

Inventors:

DUGAN LAURA L (US)
LOVETT EVA G (US)
QUICK KEVIN L (US)
HARDT JOSHUA I (US)

Application Number:

PCT/US2003/005332

Publication Date:

January 22, 2004

Filing Date:

February 20, 2003

Export Citation:

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Assignee:

UNIV WASHINGTON (US)
DUGAN LAURA L (US)
LOVETT EVA G (US)
QUICK KEVIN L (US)
HARDT JOSHUA I (US)

International Classes:

A61K45/00; A61K31/19; A61K31/194; A61P39/06; A61P43/00; C01B31/02; C07C61/39; (IPC1-7): A61K31/19; C07C309/00; B01J20/22

Foreign References:

US6265443B1

2001-07-24

Other References: