Title:
COMPOSITIONS AND METHOD FOR REGULATION OF CALCIUM-DEPENDENT SIGNALLING IN BRAIN
Document Type and Number:
WIPO Patent Application WO2003072801
Kind Code:
A3
Abstract:
Methods are provided for screening agents for activity as modulators of calcium signaling in brain tissue.
Inventors:
GREENGARD PAUL (US)
RAKHILIN SERGEY (US)
NAIRN ANGUS (US)
RAKHILIN SERGEY (US)
NAIRN ANGUS (US)
Application Number:
PCT/US2003/005273
Publication Date:
May 06, 2004
Filing Date:
February 21, 2003
Export Citation:
Assignee:
UNIV ROCKEFELLER (US)
GREENGARD PAUL (US)
RAKHILIN SERGEY (US)
NAIRN ANGUS (US)
GREENGARD PAUL (US)
RAKHILIN SERGEY (US)
NAIRN ANGUS (US)
International Classes:
G01N33/50; A61K45/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P25/30; A61P35/00; A61P43/00; C12N5/07; C12N5/078; C12N5/079; C12Q1/02; C12Q1/42; C12Q1/48; C40B30/04; G01N33/15; G01N33/53; G01N33/542; G01N33/68; (IPC1-7): A61K49/00; A61K31/00; A61K38/00; G01N33/53; G01N33/542; A01N61/00; A01N37/18
Other References:
CENTONZE ET AL.: "Dopaminergic control of synaptic plasticity in the dorsal striatum", EUROPEAN J. NEUROSCIENCE, vol. 13, 2001, pages 1071 - 1077, XP002975081
FIENBERG ET AL.: "The DARPP-32 knockout mouse", BRAIN RESEARCH REVIEWS, vol. 31, 2000, pages 313 - 319, XP002975082
GREENGARD: "The neurobiology of dopamine signalling", BIOSCIENCE REPORTS, vol. 21, no. 3, 2001, pages 247 - 269, XP002975083
FIENBERG ET AL.: "The DARPP-32 knockout mouse", BRAIN RESEARCH REVIEWS, vol. 31, 2000, pages 313 - 319, XP002975082
GREENGARD: "The neurobiology of dopamine signalling", BIOSCIENCE REPORTS, vol. 21, no. 3, 2001, pages 247 - 269, XP002975083
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