CATIONIC LIPID COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF, AND MRNA DELIVERY SYSTEM

WIPO Patent Application WO/2023/179462

A1

Disclosed in the present invention are a cationic lipid compound, a preparation method therefor and the use thereof, and an mRNA delivery system, which solve the problem of there being an urgent need to develop cationic lipids with high delivery efficiency and good immune activation properties. The structure of the cationic lipid compound is as shown in formula (I), wherein in formula (I), X is O or N, n is 2-4, m is 2-4, a is 0 or 1, R1 is a chain structure containing a tertiary amine, R2 is a linear-chain fatty acyl group or a chain fatty acyl group having a branched chain, and R3 is a chain fatty acyl group having a branched chain. The present invention is principally used to develop a cationic lipid compound, which is used for preparing an mRNA delivery system, and has the characteristics of high delivery efficiency, organ-targeted delivery and good immune activation properties.

ZHAO ZHAO (CN)
SU TAO (CN)
LI HONGYAN (CN)
LI SANPENG (CN)
GUO FENGJUAN (CN)
HE HUAMEI (CN)
WAN JI (CN)
PAN YOUDONG (CN)
WANG YI (CN)

PCT/CN2023/082055

September 28, 2023

March 17, 2023

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SHENZHEN NEOCURNA BIOTECHNOLOGY CORP (CN)
NEOCURA BIO MEDICAL TECH CO LTD (CN)
BEIJING NEOCURNA BIOTECHNOLOGY CORP (CN)

A61K9/127; C07C219/16; A61K47/18; A61K47/20; C07C227/00; C07C229/12; C07C269/00; C07C269/04; C07C271/16; C07C271/20; C07C271/22; C07C329/06; C07C333/04

WO2013086354A1

2013-06-13

US20160317458A1	2016-11-03
CN110325511A	2019-10-11
CN101163796A	2008-04-16
CN103096875A	2013-05-08
CN112262122A	2021-01-22

BEIJJING XURUN INTELLECTUAL PROPERTY AGENCY LTD. (CN)

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