Title:
CATIONIC LIPID COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF, AND MRNA DELIVERY SYSTEM
Document Type and Number:
WIPO Patent Application WO/2023/179463
Kind Code:
A1
Abstract:
The present invention relates to a cationic lipid compound, a preparation method therefor and the use thereof, and an mRNA delivery system, which relate to the technical field of medical biology. The problem of there being an urgent need to develop a cationic lipid having high delivery efficiency and good biological safety is solved. The technical solution principally used involves: the structure of the cationic lipid compound being (I), wherein R1 is a chain structure containing a tertiary amine; R2 is a chain fatty acyl; and R3 is a chain fatty acyl with a branched chain. Principally developed in the present invention is a cationic lipid compound having a high delivery efficiency, organ-targeted delivery and good biological safety, which compound is used for the preparation of an mRNA delivery system and a nucleic acid drug.
Inventors:
ZHAO ZHAO (CN)
SU TAO (CN)
LI HONGYAN (CN)
LI SANPENG (CN)
GUO FENGJUAN (CN)
HE HUAMEI (CN)
WAN JI (CN)
PAN YOUDONG (CN)
WANG YI (CN)
SU TAO (CN)
LI HONGYAN (CN)
LI SANPENG (CN)
GUO FENGJUAN (CN)
HE HUAMEI (CN)
WAN JI (CN)
PAN YOUDONG (CN)
WANG YI (CN)
Application Number:
PCT/CN2023/082056
Publication Date:
September 28, 2023
Filing Date:
March 17, 2023
Export Citation:
Assignee:
SHENZHEN NEOCURNA BIOTECHNOLOGY CORP (CN)
NEOCURA BIO MEDICAL TECH CO LTD (CN)
BEIJING NEOCURNA BIOTECHNOLOGY CORP (CN)
NEOCURA BIO MEDICAL TECH CO LTD (CN)
BEIJING NEOCURNA BIOTECHNOLOGY CORP (CN)
International Classes:
C07C219/16; A61K9/127; A61K47/18; A61K47/20; C07C213/06; C07C229/10; C07C329/06
Domestic Patent References:
| WO2015095340A1 | 2015-06-25 | |||
| WO2022060871A1 | 2022-03-24 |
Foreign References:
| CN114127044A | 2022-03-01 | |||
| CN113260607A | 2021-08-13 |
Attorney, Agent or Firm:
BEIJJING XURUN INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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