Title:
CDCA1-DERIVED PEPTIDE AND VACCINE CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2020/027239
Kind Code:
A1
Abstract:
The present invention provides an epitope peptide derived from CDCA1 that has the ability to induce cytotoxic T cells. The present invention also provides a polynucleotide encoding the peptide, an antigen-presenting cell presenting the peptide, a cytotoxic T cell targeting the peptide, and a method for inducing the antigen-presenting cell or the CTL. The present invention furthermore provides a composition or a pharmaceutical composition containing these as an active ingredient. Furthermore, the present invention provides a method for treating and/or preventing cancer as well as/or a method for preventing the postoperative recurrence of cancer using this peptide, polynucleotide, antigen-presenting cell, or cytotoxic T cell or this pharmaceutical composition. Also provided is a method for an inducing an immune response to cancer.
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Inventors:
YAMASHITA SACHIKO (JP)
HIKICHI TETSURO (JP)
HIKICHI TETSURO (JP)
Application Number:
PCT/JP2019/030117
Publication Date:
February 06, 2020
Filing Date:
August 01, 2019
Export Citation:
Assignee:
ONCOTHERAPY SCIENCE INC (JP)
International Classes:
C12N15/12; A61K35/15; A61K35/17; A61K38/08; A61K39/00; A61K39/39; A61K48/00; A61P1/00; A61P1/04; A61P1/16; A61P7/00; A61P11/00; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P21/00; A61P35/00; A61P35/02; A61P37/04; A61P43/00; C07K7/06; C12N5/0783; C12N5/10; C12Q1/02
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BOON TVAN DER BRUGGEN P, J EXP MED, vol. 184, no. 3, 1996, pages 465 - 72
HARRIS CC, J NATL CANCER INST, vol. 88, no. 20, 1996, pages 1442 - 55
BUTTERFIELD LH ET AL., CANCER RES, vol. 59, no. 21, 1999, pages 5554 - 42
VAN DER BURG SH ET AL., J IMMUNOL, vol. 156, no. 9, 1996, pages 3308 - 14
TANAKA F ET AL., CANCER RES, vol. 57, no. 20, 1997, pages 4570 - 7
KIKUCHI M ET AL., INT J CANCER, vol. 81, no. 3, 1999, pages 387 - 94
BELLI F ET AL., J CLIN ONCOL, vol. 20, no. 20, 2002, pages 4169 - 80
COULIE PG ET AL., IMMUNOL REV, vol. 188, 2002, pages 33 - 42
ROSENBERG SA ET AL., NAT MED, vol. 10, no. 9, 2004, pages 909 - 15
"GeneBank", Database accession no. NM_031423
WALKER ET AL., CURR CANCER DRUG TARGETS, vol. 1, no. 1, 2001, pages 73 - 83
WIGGE PA ET AL., J CELL BIOL, vol. 152, no. 2, 2001, pages 349 - 60
HAYAMA ET AL., CANCER RES, vol. 66, no. 21, 2006, pages 10339 - 48
HARAO M ET AL., INT J CANCER, vol. 123, no. 11, 2008, pages 2616 - 25
CAO K ET AL., HUM IMMUNOL, vol. 62, no. 9, 2001, pages 1009 - 30
MARK ET AL., PROC NATL ACAD SCI USA, vol. 81, 1984, pages 5662 - 6
ZOLLERSMITH, NUCLEIC ACIDS RES, vol. 10, 1982, pages 6487 - 500
DALBADIE-MCFARLAND ET AL., PROC NATL ACAD SCI USA, vol. 79, 1982, pages 6409 - 13
FALK ET AL., IMMUNOGENETICS, vol. 40, 1994, pages 238 - 41
CHUJOH ET AL., TISSUE ANTIGENS, vol. 52, 1998, pages 501 - 9
TAKIGUCHI ET AL., TISSUE ANTIGENS, vol. 55, 2000, pages 296 - 302
RAMMENSEE HG ET AL., IMMUNOGENETICS, vol. 41, no. 4, 1995, pages 178 - 228
KUBO, R.T, JOURNAL OF IMMUNOLOGY, vol. 152, 1994, pages 3913 - 24
GAMBACORTI-PASSERINI, C, CLINICAL CANCER RESEARCH, vol. 3, 1997, pages 675 - 83
K. S. KAWAMURA ET AL., J IMMUNOL, vol. 168, no. 3, 2002, pages 5709 - 15
S. O. DIONNE ET AL., CANCER IMMUNOL IMMUNOTHER, vol. 52, 2003, pages 199 - 206
S. O. DIONNE ET AL.: "Cancer Immunology", IMMUNOTHERAPY, vol. 53, 2004, pages 307 - 14
P. M. DAFTARIAN ET AL., J TRANS MED, vol. 5, 2007, pages 26
R. P. M. SUTMULLER ET AL., J IMMUNOL, vol. 165, 2000, pages 7308 - 15
S. OTA ET AL., CAN RES, vol. 62, 2002, pages 1471 - 6
VERHOEF ET AL., EUR J DRUG METAB PHARMACOKIN, vol. 11, 1986, pages 291 - 302
"Peptide Synthesis", 1966, INTERSCIENCE
"The Proteins", vol. 2, 1976, ACADEMIC PRESS
"Peptide Synthesis'' (in Japanese", 1975, MARUZEN CO.
"Basics and Experiment of Peptide Synthesis'' (in Japanese", 1985, MARUZEN CO.
"Development of Pharmaceuticals'' (in Japanese", vol. 14, 1991, HIROKAWA, article "peptide synthesis"
BARANY G.MERRIFIELD R.B.: "Peptides", vol. 2, 1980, ACADEMIC PRESS, article "Solid Phase Peptide Synthesis", pages: 100 - 118
MORRISON J, J BACTERIOLOGY, vol. 132, 1977, pages 349 - 51
CLARK-CURTISSCURTISS, WU ET AL., METHODS IN ENZYMOLOGY, vol. 101, 1983, pages 347 - 62
"GenBank", Database accession no. NM_145697
KAWAKAMI ET AL., J IMMUNOL., vol. 142, 1989, pages 3452 - 61
BEAUCAGE SLIYER RP, TETRAHEDRON, vol. 48, 1992, pages 2223 - 311
MATTHES ET AL., EMBO J, vol. 3, 1984, pages 801 - 5
CANCER RES, vol. 56, 1996, pages 5672 - 7
J IMMUNOL, vol. 161, 1998, pages 5607 - 13
MORGAN ET AL., J IMMUNOL, vol. 171, 2003, pages 3288
CLIN MICROBIOL REV, vol. 7, 1994, pages 277 - 89
DERES ET AL., NATURE, vol. 341, 1989, pages 544 - 6
THOMAS KRCAPECCHI MR, CELL, vol. 51, 1987, pages 503 - 12
WOLFF ET AL., SCIENCE, vol. 247, 1990, pages 1465 - 8
STOVER ET AL., NATURE, vol. 351, 1991, pages 456 - 60
SHATA ET AL., MOL MED TODAY, vol. 6, 2000, pages 66 - 71
SHEDLOCK ET AL., J LEUKOC BIOL, vol. 68, 2000, pages 793 - 806
HIPP ET AL., VIVO, vol. 14, 2000, pages 571 - 85
GOLDSPIEL ET AL., CLINICAL PHARMACY, vol. 12, 1993, pages 488 - 505
WUWU, BIOTHERAPY, vol. 3, 1991, pages 87 - 95
TOLSTOSHEV, ANN REV PHARMACOL TOXICOL, vol. 33, 1993, pages 573 - 96
MULLIGAN, SCIENCE, vol. 260, 1993, pages 926 - 32
MORGANANDERSON, ANN REV BIOCHEM, vol. 62, 1993, pages 191 - 217
TRENDS IN BIOTECHNOLOGY, vol. 11, no. 5, 1993, pages 155 - 215
AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1993, JOHN WILEY & SONS
MIZUSHIMA ET AL., NUCLEIC ACIDS RES, vol. 18, no. 17, 1990, pages 5322
KNABEL M ET AL., NAT MED, vol. 8, no. 6, 2002, pages 631 - 7
ALTMAN JD ET AL., SCIENCE, vol. 274, no. 5284, 1996, pages 94 - 6
GALFREMILSTEIN, METHODS ENZYMOL, vol. 73, 1981, pages 3 - 46
HUSTON ET AL., PROC NATL ACAD SCI USA, vol. 85, 1988, pages 5879 - 83
PARKER KC ET AL., J IMMUNOL, vol. 152, no. 1, 1994, pages 2968 - 75
PLUCKTHUNSKERRA, METHODS ENZYMOL, vol. 178, 1989, pages 497 - 515
ROUSSEAUX ET AL., METHODS ENZYMOL, vol. 121, 1986, pages 663 - 63
BIRDWALKER, TRENDS BIOTECHNOL, vol. 9, 1991, pages 132 - 7
VERHOEYEN ET AL., SCIENCE, vol. 240, 1988, pages 1041 - 3
HOOGENBOOMWINTER, J. MOL. BIOL., vol. 227, 1991, pages 381
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
RIDDELL SR ET AL., NAT MED, vol. 2, no. 2, 1996, pages 216 - 23
FASEB J, vol. 6, 1989, pages 2422 - 7
LEI ET AL., J BACTERIOL, vol. 169, 1987, pages 4379
MULLIGAN ET AL., NATURE, vol. 277, 1979, pages 108
BUUS ET AL., TISSUE ANTIGENS, vol. 62, no. 5, 2003, pages 378 - 84
NIELSEN ET AL., PROTEIN SCI, vol. 12, no. 5, 2003, pages 1007 - 17
LUNDEGAARD C ET AL., BIOINFORMATICS, vol. 24, no. 11, 2008, pages 1397 - 98
RAMMENSEE HG ET AL., IMMUNOGENETICS, vol. 50, no. 3-4, 1999, pages 213 - 9
NAKAHARA S ET AL., CANCER RES, vol. 63, no. 14, 2003, pages 4112 - 8
TANAKA H ET AL., BR J CANCER, vol. 84, no. 8, 2001, pages 1052 - 7
UCHIDA N ET AL., CLIN CANCER RES, vol. 10, no. 24, 2004, pages 8577 - 86
SUDA T ET AL., CANCER SCI, vol. 97, no. 5, 2006, pages 411 - 9
WATANABE T ET AL., CANCER SCI, vol. 96, no. 8, 2005, pages 498 - 506
WALTER EA ET AL., N ENGL J MED, vol. 333, no. 16, 1995, pages 1038 - 44
See also references of EP 3831943A4
BOON TVAN DER BRUGGEN P, J EXP MED, vol. 184, no. 3, 1996, pages 465 - 72
HARRIS CC, J NATL CANCER INST, vol. 88, no. 20, 1996, pages 1442 - 55
BUTTERFIELD LH ET AL., CANCER RES, vol. 59, no. 21, 1999, pages 5554 - 42
VAN DER BURG SH ET AL., J IMMUNOL, vol. 156, no. 9, 1996, pages 3308 - 14
TANAKA F ET AL., CANCER RES, vol. 57, no. 20, 1997, pages 4570 - 7
KIKUCHI M ET AL., INT J CANCER, vol. 81, no. 3, 1999, pages 387 - 94
BELLI F ET AL., J CLIN ONCOL, vol. 20, no. 20, 2002, pages 4169 - 80
COULIE PG ET AL., IMMUNOL REV, vol. 188, 2002, pages 33 - 42
ROSENBERG SA ET AL., NAT MED, vol. 10, no. 9, 2004, pages 909 - 15
"GeneBank", Database accession no. NM_031423
WALKER ET AL., CURR CANCER DRUG TARGETS, vol. 1, no. 1, 2001, pages 73 - 83
WIGGE PA ET AL., J CELL BIOL, vol. 152, no. 2, 2001, pages 349 - 60
HAYAMA ET AL., CANCER RES, vol. 66, no. 21, 2006, pages 10339 - 48
HARAO M ET AL., INT J CANCER, vol. 123, no. 11, 2008, pages 2616 - 25
CAO K ET AL., HUM IMMUNOL, vol. 62, no. 9, 2001, pages 1009 - 30
MARK ET AL., PROC NATL ACAD SCI USA, vol. 81, 1984, pages 5662 - 6
ZOLLERSMITH, NUCLEIC ACIDS RES, vol. 10, 1982, pages 6487 - 500
DALBADIE-MCFARLAND ET AL., PROC NATL ACAD SCI USA, vol. 79, 1982, pages 6409 - 13
FALK ET AL., IMMUNOGENETICS, vol. 40, 1994, pages 238 - 41
CHUJOH ET AL., TISSUE ANTIGENS, vol. 52, 1998, pages 501 - 9
TAKIGUCHI ET AL., TISSUE ANTIGENS, vol. 55, 2000, pages 296 - 302
RAMMENSEE HG ET AL., IMMUNOGENETICS, vol. 41, no. 4, 1995, pages 178 - 228
KUBO, R.T, JOURNAL OF IMMUNOLOGY, vol. 152, 1994, pages 3913 - 24
GAMBACORTI-PASSERINI, C, CLINICAL CANCER RESEARCH, vol. 3, 1997, pages 675 - 83
K. S. KAWAMURA ET AL., J IMMUNOL, vol. 168, no. 3, 2002, pages 5709 - 15
S. O. DIONNE ET AL., CANCER IMMUNOL IMMUNOTHER, vol. 52, 2003, pages 199 - 206
S. O. DIONNE ET AL.: "Cancer Immunology", IMMUNOTHERAPY, vol. 53, 2004, pages 307 - 14
P. M. DAFTARIAN ET AL., J TRANS MED, vol. 5, 2007, pages 26
R. P. M. SUTMULLER ET AL., J IMMUNOL, vol. 165, 2000, pages 7308 - 15
S. OTA ET AL., CAN RES, vol. 62, 2002, pages 1471 - 6
VERHOEF ET AL., EUR J DRUG METAB PHARMACOKIN, vol. 11, 1986, pages 291 - 302
"Peptide Synthesis", 1966, INTERSCIENCE
"The Proteins", vol. 2, 1976, ACADEMIC PRESS
"Peptide Synthesis'' (in Japanese", 1975, MARUZEN CO.
"Basics and Experiment of Peptide Synthesis'' (in Japanese", 1985, MARUZEN CO.
"Development of Pharmaceuticals'' (in Japanese", vol. 14, 1991, HIROKAWA, article "peptide synthesis"
BARANY G.MERRIFIELD R.B.: "Peptides", vol. 2, 1980, ACADEMIC PRESS, article "Solid Phase Peptide Synthesis", pages: 100 - 118
MORRISON J, J BACTERIOLOGY, vol. 132, 1977, pages 349 - 51
CLARK-CURTISSCURTISS, WU ET AL., METHODS IN ENZYMOLOGY, vol. 101, 1983, pages 347 - 62
"GenBank", Database accession no. NM_145697
KAWAKAMI ET AL., J IMMUNOL., vol. 142, 1989, pages 3452 - 61
BEAUCAGE SLIYER RP, TETRAHEDRON, vol. 48, 1992, pages 2223 - 311
MATTHES ET AL., EMBO J, vol. 3, 1984, pages 801 - 5
CANCER RES, vol. 56, 1996, pages 5672 - 7
J IMMUNOL, vol. 161, 1998, pages 5607 - 13
MORGAN ET AL., J IMMUNOL, vol. 171, 2003, pages 3288
CLIN MICROBIOL REV, vol. 7, 1994, pages 277 - 89
DERES ET AL., NATURE, vol. 341, 1989, pages 544 - 6
THOMAS KRCAPECCHI MR, CELL, vol. 51, 1987, pages 503 - 12
WOLFF ET AL., SCIENCE, vol. 247, 1990, pages 1465 - 8
STOVER ET AL., NATURE, vol. 351, 1991, pages 456 - 60
SHATA ET AL., MOL MED TODAY, vol. 6, 2000, pages 66 - 71
SHEDLOCK ET AL., J LEUKOC BIOL, vol. 68, 2000, pages 793 - 806
HIPP ET AL., VIVO, vol. 14, 2000, pages 571 - 85
GOLDSPIEL ET AL., CLINICAL PHARMACY, vol. 12, 1993, pages 488 - 505
WUWU, BIOTHERAPY, vol. 3, 1991, pages 87 - 95
TOLSTOSHEV, ANN REV PHARMACOL TOXICOL, vol. 33, 1993, pages 573 - 96
MULLIGAN, SCIENCE, vol. 260, 1993, pages 926 - 32
MORGANANDERSON, ANN REV BIOCHEM, vol. 62, 1993, pages 191 - 217
TRENDS IN BIOTECHNOLOGY, vol. 11, no. 5, 1993, pages 155 - 215
AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1993, JOHN WILEY & SONS
MIZUSHIMA ET AL., NUCLEIC ACIDS RES, vol. 18, no. 17, 1990, pages 5322
KNABEL M ET AL., NAT MED, vol. 8, no. 6, 2002, pages 631 - 7
ALTMAN JD ET AL., SCIENCE, vol. 274, no. 5284, 1996, pages 94 - 6
GALFREMILSTEIN, METHODS ENZYMOL, vol. 73, 1981, pages 3 - 46
HUSTON ET AL., PROC NATL ACAD SCI USA, vol. 85, 1988, pages 5879 - 83
PARKER KC ET AL., J IMMUNOL, vol. 152, no. 1, 1994, pages 2968 - 75
PLUCKTHUNSKERRA, METHODS ENZYMOL, vol. 178, 1989, pages 497 - 515
ROUSSEAUX ET AL., METHODS ENZYMOL, vol. 121, 1986, pages 663 - 63
BIRDWALKER, TRENDS BIOTECHNOL, vol. 9, 1991, pages 132 - 7
VERHOEYEN ET AL., SCIENCE, vol. 240, 1988, pages 1041 - 3
HOOGENBOOMWINTER, J. MOL. BIOL., vol. 227, 1991, pages 381
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
RIDDELL SR ET AL., NAT MED, vol. 2, no. 2, 1996, pages 216 - 23
FASEB J, vol. 6, 1989, pages 2422 - 7
LEI ET AL., J BACTERIOL, vol. 169, 1987, pages 4379
MULLIGAN ET AL., NATURE, vol. 277, 1979, pages 108
BUUS ET AL., TISSUE ANTIGENS, vol. 62, no. 5, 2003, pages 378 - 84
NIELSEN ET AL., PROTEIN SCI, vol. 12, no. 5, 2003, pages 1007 - 17
LUNDEGAARD C ET AL., BIOINFORMATICS, vol. 24, no. 11, 2008, pages 1397 - 98
RAMMENSEE HG ET AL., IMMUNOGENETICS, vol. 50, no. 3-4, 1999, pages 213 - 9
NAKAHARA S ET AL., CANCER RES, vol. 63, no. 14, 2003, pages 4112 - 8
TANAKA H ET AL., BR J CANCER, vol. 84, no. 8, 2001, pages 1052 - 7
UCHIDA N ET AL., CLIN CANCER RES, vol. 10, no. 24, 2004, pages 8577 - 86
SUDA T ET AL., CANCER SCI, vol. 97, no. 5, 2006, pages 411 - 9
WATANABE T ET AL., CANCER SCI, vol. 96, no. 8, 2005, pages 498 - 506
WALTER EA ET AL., N ENGL J MED, vol. 333, no. 16, 1995, pages 1038 - 44
See also references of EP 3831943A4
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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