Title:
CDK8 INHIBITORS, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/185673
Kind Code:
A1
Abstract:
Provided in the present invention are CDK8 inhibitors, a preparation method therefor and the use thereof, belonging to the field of biological medicines. The CDK8 inhibitors of the present invention are compounds represented by formula (I), or optical isomers, pharmaceutically acceptable salts, hydrates or solvates thereof. The compounds of the present invention have excellent CDK8 inhibiting effect, can be clinically used as CDK8 inhibitors, provide a new choice for treating tumor-related diseases, such as leukemia, and have great application prospects.
Inventors:
CHENG HANG (CN)
SONG XUEQIN (CN)
XIONG WEIYAN (CN)
SHI PENGYI (CN)
NIU WEI (CN)
YU BIN (CN)
ZHANG MIN (CN)
JIANG YU (CN)
SONG XUEQIN (CN)
XIONG WEIYAN (CN)
SHI PENGYI (CN)
NIU WEI (CN)
YU BIN (CN)
ZHANG MIN (CN)
JIANG YU (CN)
Application Number:
PCT/CN2023/083657
Publication Date:
October 05, 2023
Filing Date:
March 24, 2023
Export Citation:
Assignee:
CHENGDU CYNOGEN BIO PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
A61K31/56; C07J43/00; A61P35/00; C07J1/00; C07J41/00
Foreign References:
| CN113613658A | 2021-11-05 | |||
| CN109354598A | 2019-02-19 | |||
| US20140005132A1 | 2014-01-02 | |||
| CN1348461A | 2002-05-08 | |||
| CN108713023A | 2018-10-26 |
Other References:
KOTOVSHCHIKOV YURY N., LATYSHEV GENNADIJ V., LUKASHEV NIKOLAY V., BELETSKAYA IRINA P.: "Alkynylation of steroids via Pd-free Sonogashira coupling", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 13, no. 19, 1 January 2015 (2015-01-01), pages 5542 - 5555, XP093096716, ISSN: 1477-0520, DOI: 10.1039/C5OB00559K
CHRISTOPHE DUPLAIS; ARNOLD J. FORMAN; BENJAMIN A. BAKER; BRUCE H. LIPSHUTZ: "UC Pd: A New Form of Pd/C for Sonogashira Couplings", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 16, no. 11, 5 February 2010 (2010-02-05), DE, pages 3366 - 3371, XP071830785, ISSN: 0947-6539, DOI: 10.1002/chem.200902471
CHRISTOPHE DUPLAIS; ARNOLD J. FORMAN; BENJAMIN A. BAKER; BRUCE H. LIPSHUTZ: "UC Pd: A New Form of Pd/C for Sonogashira Couplings", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 16, no. 11, 5 February 2010 (2010-02-05), DE, pages 3366 - 3371, XP071830785, ISSN: 0947-6539, DOI: 10.1002/chem.200902471
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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