Title:
CELL SHEET CLAMPING DEVICE, USE METHOD, AND PREPARATION METHOD FOR NEURORESTORATIVE MATERIAL
Document Type and Number:
WIPO Patent Application WO/2023/245812
Kind Code:
A1
Abstract:
A cell sheet clamping device, a use method, and a preparation method for a neurorestorative material. The cell sheet clamping device comprises a frame, a fixed plate being fixedly arranged on the frame. A first clamping member is adjustably arranged on the frame and cooperates with the fixed plate so as to clamp one end of a cell sheet. A movable plate is movably arranged on the frame. A second clamping member is adjustably arranged on the frame and cooperates with the movable plate so as to clamp the other end of the cell sheet. The movable plate can move relatively close to or far away from the fixed plate in a preset plane, and when the movable plate moves in the preset plane, the second clamping member moves synchronously. One end of a cell sheet is clamped by the cooperated first clamping member and fixed plate, while the other end of the cell sheet is clamped by the cooperated second clamping member and movable plate; the second clamping member and the movable plate are synchronously adjusted such that the cell sheet has a natural length; and then the positions of the fixed plate and the movable plate are relatively fixed and cells are cultured for a preset time, so that the cell sheet spontaneously rolls up into a cylindrical shape to form a neurorestorative material.
Inventors:
GAO BOTAO (CN)
FENG JIE (CN)
FENG JIE (CN)
Application Number:
PCT/CN2022/108693
Publication Date:
December 28, 2023
Filing Date:
July 28, 2022
Export Citation:
Assignee:
INST OF BIOLOGICAL AND MEDICAL ENGINEERING GUANGDONG ACADEMY OF SCIENCES (CN)
International Classes:
C12M3/00; A61L27/38; C12M3/02; C12N5/077; C12N5/079
Foreign References:
| CN101892152A | 2010-11-24 | |||
| CN106635961A | 2017-05-10 | |||
| CN110964637A | 2020-04-07 | |||
| CN102433258A | 2012-05-02 | |||
| CN110343614A | 2019-10-18 | |||
| CN112322492A | 2021-02-05 | |||
| CN104178422A | 2014-12-03 | |||
| US20160032234A1 | 2016-02-04 |
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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