CELL THERAPY PRODUCT FOR BONE REGENERATION AND PREPARATION METHOD THEREFOR

Title:

CELL THERAPY PRODUCT FOR BONE REGENERATION AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2018/139869

Kind Code:

A1

Abstract:

The present invention relates to a cell therapy product for treatment of a bone disease, which is prepared by mixing bone cells differentiated from umbilical cord-derived mesenchymal stem cells with undifferentiated, umbilical cord-derived mesenchymal stem cells at a certain ratio. More particularly, the present invention can provide a cell therapy product capable of effectively treating bone diseases, wherein differentiated bone cells are mixed at a ratio of 0.5 to 1.5 with undifferentiated cells, whereby the undifferentiated cells promote angiogenesis and thus bone reconstruction or osteogenesis.

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Inventors:

PARK HYUN SOOK (KR)
LEE SUN RAY (KR)
LEE JONG MIN (KR)
PARK JANG MI (KR)
CHU SEOL (KR)
MO HYUN JUNG (KR)

Application Number:

PCT/KR2018/001114

Publication Date:

August 02, 2018

Filing Date:

January 25, 2018

Export Citation:

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Assignee:

CEFO CO LTD (KR)

International Classes:

A61K35/32; A61K35/28; A61K35/35; A61K35/51; A61K35/545

Foreign References:

KR20120021391A	2012-03-09
KR20070113572A	2007-11-29
US20100055078A1	2010-03-04

Other References:

BIRMINGHAM, E.: "Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche", EUROPEAN CELLS & MATERIALS, vol. 23, 2012, pages 13 - 27, XP055559822
TSAI, M.-T.: "Osteogenic differentiation is synergistically influenced by osteoinductive treatment and direct cell - cell contact between murine osteoblasts and mesenchymal stem cells", INTERNATIONAL ORTHOPAEDICS, vol. 36, no. 1, 2012, pages 199 - 205, XP 019998027
KIM, H.: "Interaction of mesenchymal stem cells and osteoblasts for in vitro osteogenesis", YONSEI MEDICAL JOURNAL, vol. 44, no. 2, 2003, pages 187 - 197, XP 055531586

Attorney, Agent or Firm:

NAM & NAM WORLD PATENT & LAW FIRM (KR)

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