Title:
CELLS HAVING ABILITY TO INDUCE SKIN APPENDAGES, AND PRODUCTION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/244502
Kind Code:
A1
Abstract:
[Problem] To directly convert somatic cells into cells that have an ability to form a stratified epithelial tissue capable of acting as the body outer skin and also have an ability to induce skin appendages. [Solution] A production method of cells that have an ability to induce skin appendages, said method comprising a step for introducing into somatic cells at least one gene that is relatively strongly expressed in cells having the ability to induce skin appendages.
Inventors:
KURITA MASAKAZU (JP)
Application Number:
PCT/JP2022/015867
Publication Date:
November 24, 2022
Filing Date:
March 30, 2022
Export Citation:
Assignee:
KURITA MASAKAZU (JP)
International Classes:
C12N5/10; A01K67/027; A61K35/35; A61K35/36; A61P17/00; C12N15/12; C12N15/64
Foreign References:
| JP2001520202A | 2001-10-30 |
Other References:
OKAZAKI MUTSUMI, MASAKAZU KURITA, KOJI KANAYAMA: "Development of New Hair Generation Inducement Method Using Direct Substitution of Cell Lines", 2019 FISCAL YEAR ANNUAL RESEARCH REPORT. KAKENHI, THE UNIVERSITY OF TOKYO, 1 January 2019 (2019-01-01), The University of Tokyo, XP093006045, Retrieved from the Internet [retrieved on 20221208]
KURITA MASAKAZU; ARAOKA TOSHIKAZU; HISHIDA TOMOAKI; O’KEEFE DAVID D.; TAKAHASHI YUTA; SAKAMOTO AKIHISA; SAKURAI MASAHIRO; SU: "In vivo reprogramming of wound-resident cells generates skin epithelial tissue", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 561, no. 7722, 5 September 2018 (2018-09-05), London, pages 243 - 247, XP036590178, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0477-4
ABACI HASAN ERBIL, COFFMAN ABIGAIL, DOUCET YANNE, CHEN JAMES, JACKÓW JOANNA, WANG ETIENNE, GUO ZONGYOU, SHIN JUNG U., JAHODA COLIN: "Tissue engineering of human hair follicles using a biomimetic developmental approach", NATURE COMMUNICATIONS, vol. 9, no. 1, 1 December 2018 (2018-12-01), pages 1038, XP093005811, DOI: 10.1038/s41467-018-07579-y
PHAN QUAN M, FINE GRACELYN M, SALZ LUCIA, HERRERA GERARDO G, WILDMAN BEN, DRISKELL IWONA M, DRISKELL RYAN R: "Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds", ELIFE, vol. 9, pages e60066, XP093005815, DOI: 10.7554/eLife.60066
LIM CHAE HO, SUN QI, RATTI KARAN, LEE SOUNG-HOON, ZHENG YING, TAKEO MAKOTO, LEE WENDY, RABBANI PIUL, PLIKUS MAKSIM V., CAIN JASON : "Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing", NATURE COMMUNICATIONS, vol. 9, no. 1, 1 December 2018 (2018-12-01), pages 4903, XP093005817, DOI: 10.1038/s41467-018-07142-9
MOK KA-WAI, SAXENA NIVEDITA, HEITMAN NICHOLAS, GRISANTI LAURA, SRIVASTAVA DEVIKA, MURARO MAURO J., JACOB TINA, SENNETT RACHEL, WAN: "Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent", DEVELOPMENTAL CELL, CELL PRESS, US, vol. 48, no. 1, 1 January 2019 (2019-01-01), US , pages 32 - 48.e5, XP093005819, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.11.034
GE WEI, TAN SHAO-JING, WANG SHAN-HE, LI LAN, SUN XIAO-FENG, SHEN WEI, WANG XIN: "Single-cell Transcriptome Profiling reveals Dermal and Epithelial cell fate decisions during Embryonic Hair Follicle Development", THERANOSTICS, IVYSPRING INTERNATIONAL PUBLISHER, AU, vol. 10, no. 17, 1 January 2020 (2020-01-01), AU , pages 7581 - 7598, XP093005822, ISSN: 1838-7640, DOI: 10.7150/thno.44306
TELERMAN STEPHANIE B., ROGNONI EMANUEL, SEQUEIRA INÊS, PISCO ANGELA OLIVEIRA, LICHTENBERGER BEATE M., CULLEY OLIVER J., VISWANATHA: "Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth", JOURNAL OF INVESTIGATIVE DERMATOLOGY, ELSEVIER, NL, vol. 137, no. 11, 1 November 2017 (2017-11-01), NL , pages 2270 - 2281, XP093005823, ISSN: 0022-202X, DOI: 10.1016/j.jid.2017.06.015
SONG KE, RAO NIAN-JING, CHEN MEI-LING, HUANG ZHENG-JIANG, CAO YING-GUANG: "Enhanced bone regeneration with sequential delivery of basic fibroblast growth factor and sonic hedgehog", INJURY, JOHN WRIGHT AND SONS, BRISTOL, GB, vol. 42, no. 8, 1 August 2011 (2011-08-01), GB , pages 796 - 802, XP093005825, ISSN: 0020-1383, DOI: 10.1016/j.injury.2011.02.003
DING BAOJIN, CAVE JOHN W., DOBNER PAUL R., MULLIKIN-KILPATRICK DEBRA, BARTZOKIS MARINA, ZHU HONG, CHOW CHI-WING, GRONOSTAJSKI RICH: "Reciprocal autoregulation by NFI occupancy and ETV1 promotes the developmental expression of dendrite-synapse genes in cerebellar granule neurons", MOLECULAR BIOLOGY OF THE CELL, AMERICAN SOCIETY FOR CELL BIOLOGY, US, vol. 27, no. 9, 1 May 2016 (2016-05-01), US , pages 1488 - 1499, XP093005839, ISSN: 1059-1524, DOI: 10.1091/mbc.E15-07-0476
HAN JIANGYUAN, MA YANLIN, MA LAN, TAN DAQUAN, NIU HONGXIA, BAI CHUNXIANG, MI YOUJUN, XIE TAO, LV WEI, WANG JUAN, ZHU BINGDONG: "Id3 and Bcl6 Promote the Development of Long-Term Immune Memory Induced by Tuberculosis Subunit Vaccine", VACCINES, vol. 9, no. 2, 5 February 2021 (2021-02-05), pages 126, XP093005841, DOI: 10.3390/vaccines9020126
FU LINA, HU YUQIONG, SONG MOSHI, LIU ZUNPENG, ZHANG WEIQI, YU FA-XING, WU JUN, WANG SI, IZPISUA BELMONTE JUAN CARLOS, CHAN PIU, QU: "Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis", PLOS BIOLOGY, vol. 17, no. 4, 1 April 2019 (2019-04-01), pages e3000201, XP093005843, DOI: 10.1371/journal.pbio.3000201
KURITA MASAKAZU; ARAOKA TOSHIKAZU; HISHIDA TOMOAKI; O’KEEFE DAVID D.; TAKAHASHI YUTA; SAKAMOTO AKIHISA; SAKURAI MASAHIRO; SU: "In vivo reprogramming of wound-resident cells generates skin epithelial tissue", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 561, no. 7722, 5 September 2018 (2018-09-05), London, pages 243 - 247, XP036590178, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0477-4
ABACI HASAN ERBIL, COFFMAN ABIGAIL, DOUCET YANNE, CHEN JAMES, JACKÓW JOANNA, WANG ETIENNE, GUO ZONGYOU, SHIN JUNG U., JAHODA COLIN: "Tissue engineering of human hair follicles using a biomimetic developmental approach", NATURE COMMUNICATIONS, vol. 9, no. 1, 1 December 2018 (2018-12-01), pages 1038, XP093005811, DOI: 10.1038/s41467-018-07579-y
PHAN QUAN M, FINE GRACELYN M, SALZ LUCIA, HERRERA GERARDO G, WILDMAN BEN, DRISKELL IWONA M, DRISKELL RYAN R: "Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds", ELIFE, vol. 9, pages e60066, XP093005815, DOI: 10.7554/eLife.60066
LIM CHAE HO, SUN QI, RATTI KARAN, LEE SOUNG-HOON, ZHENG YING, TAKEO MAKOTO, LEE WENDY, RABBANI PIUL, PLIKUS MAKSIM V., CAIN JASON : "Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing", NATURE COMMUNICATIONS, vol. 9, no. 1, 1 December 2018 (2018-12-01), pages 4903, XP093005817, DOI: 10.1038/s41467-018-07142-9
MOK KA-WAI, SAXENA NIVEDITA, HEITMAN NICHOLAS, GRISANTI LAURA, SRIVASTAVA DEVIKA, MURARO MAURO J., JACOB TINA, SENNETT RACHEL, WAN: "Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent", DEVELOPMENTAL CELL, CELL PRESS, US, vol. 48, no. 1, 1 January 2019 (2019-01-01), US , pages 32 - 48.e5, XP093005819, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.11.034
GE WEI, TAN SHAO-JING, WANG SHAN-HE, LI LAN, SUN XIAO-FENG, SHEN WEI, WANG XIN: "Single-cell Transcriptome Profiling reveals Dermal and Epithelial cell fate decisions during Embryonic Hair Follicle Development", THERANOSTICS, IVYSPRING INTERNATIONAL PUBLISHER, AU, vol. 10, no. 17, 1 January 2020 (2020-01-01), AU , pages 7581 - 7598, XP093005822, ISSN: 1838-7640, DOI: 10.7150/thno.44306
TELERMAN STEPHANIE B., ROGNONI EMANUEL, SEQUEIRA INÊS, PISCO ANGELA OLIVEIRA, LICHTENBERGER BEATE M., CULLEY OLIVER J., VISWANATHA: "Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth", JOURNAL OF INVESTIGATIVE DERMATOLOGY, ELSEVIER, NL, vol. 137, no. 11, 1 November 2017 (2017-11-01), NL , pages 2270 - 2281, XP093005823, ISSN: 0022-202X, DOI: 10.1016/j.jid.2017.06.015
SONG KE, RAO NIAN-JING, CHEN MEI-LING, HUANG ZHENG-JIANG, CAO YING-GUANG: "Enhanced bone regeneration with sequential delivery of basic fibroblast growth factor and sonic hedgehog", INJURY, JOHN WRIGHT AND SONS, BRISTOL, GB, vol. 42, no. 8, 1 August 2011 (2011-08-01), GB , pages 796 - 802, XP093005825, ISSN: 0020-1383, DOI: 10.1016/j.injury.2011.02.003
DING BAOJIN, CAVE JOHN W., DOBNER PAUL R., MULLIKIN-KILPATRICK DEBRA, BARTZOKIS MARINA, ZHU HONG, CHOW CHI-WING, GRONOSTAJSKI RICH: "Reciprocal autoregulation by NFI occupancy and ETV1 promotes the developmental expression of dendrite-synapse genes in cerebellar granule neurons", MOLECULAR BIOLOGY OF THE CELL, AMERICAN SOCIETY FOR CELL BIOLOGY, US, vol. 27, no. 9, 1 May 2016 (2016-05-01), US , pages 1488 - 1499, XP093005839, ISSN: 1059-1524, DOI: 10.1091/mbc.E15-07-0476
HAN JIANGYUAN, MA YANLIN, MA LAN, TAN DAQUAN, NIU HONGXIA, BAI CHUNXIANG, MI YOUJUN, XIE TAO, LV WEI, WANG JUAN, ZHU BINGDONG: "Id3 and Bcl6 Promote the Development of Long-Term Immune Memory Induced by Tuberculosis Subunit Vaccine", VACCINES, vol. 9, no. 2, 5 February 2021 (2021-02-05), pages 126, XP093005841, DOI: 10.3390/vaccines9020126
FU LINA, HU YUQIONG, SONG MOSHI, LIU ZUNPENG, ZHANG WEIQI, YU FA-XING, WU JUN, WANG SI, IZPISUA BELMONTE JUAN CARLOS, CHAN PIU, QU: "Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis", PLOS BIOLOGY, vol. 17, no. 4, 1 April 2019 (2019-04-01), pages e3000201, XP093005843, DOI: 10.1371/journal.pbio.3000201
Attorney, Agent or Firm:
ISODA Shiro (JP)
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