Title:
CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
Document Type and Number:
WIPO Patent Application WO/2005/107762
Kind Code:
A2
Abstract:
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
Inventors:
QIAN XIANGPING (US)
MCDONALD ANDREW I (US)
ZHOU HAN-JIE (US)
ASHCRAFT LUKE W (US)
YAO BING (US)
JIANG HONG (US)
HUANG JENNIFER KUO CHEN (US)
WANG JIANCHAO (US)
MORGANS DAVID J JR (US)
MORGAN BRADLEY P (US)
BERGNES GUSTAVE (US)
DHANAK DASHYANT (US)
KNIGHT STEVEN D (US)
ADAMS NICHOLAS D (US)
PARRISH CYNTHIA A (US)
MCDONALD ANDREW I (US)
ZHOU HAN-JIE (US)
ASHCRAFT LUKE W (US)
YAO BING (US)
JIANG HONG (US)
HUANG JENNIFER KUO CHEN (US)
WANG JIANCHAO (US)
MORGANS DAVID J JR (US)
MORGAN BRADLEY P (US)
BERGNES GUSTAVE (US)
DHANAK DASHYANT (US)
KNIGHT STEVEN D (US)
ADAMS NICHOLAS D (US)
PARRISH CYNTHIA A (US)
Application Number:
PCT/US2005/015666
Publication Date:
November 17, 2005
Filing Date:
May 06, 2005
Export Citation:
Assignee:
CYTOKINETICS INC (US)
SMITHKLINE BEECHAM CORP (US)
QIAN XIANGPING (US)
MCDONALD ANDREW I (US)
ZHOU HAN-JIE (US)
ASHCRAFT LUKE W (US)
YAO BING (US)
JIANG HONG (US)
HUANG JENNIFER KUO CHEN (US)
WANG JIANCHAO (US)
MORGANS DAVID J JR (US)
MORGAN BRADLEY P (US)
BERGNES GUSTAVE (US)
DHANAK DASHYANT (US)
KNIGHT STEVEN D (US)
ADAMS NICHOLAS D (US)
PARRISH CYNTHIA A (US)
SMITHKLINE BEECHAM CORP (US)
QIAN XIANGPING (US)
MCDONALD ANDREW I (US)
ZHOU HAN-JIE (US)
ASHCRAFT LUKE W (US)
YAO BING (US)
JIANG HONG (US)
HUANG JENNIFER KUO CHEN (US)
WANG JIANCHAO (US)
MORGANS DAVID J JR (US)
MORGAN BRADLEY P (US)
BERGNES GUSTAVE (US)
DHANAK DASHYANT (US)
KNIGHT STEVEN D (US)
ADAMS NICHOLAS D (US)
PARRISH CYNTHIA A (US)
International Classes:
A61K31/4184; A61K31/4196; A61K31/421; A61K31/424; A61K31/4745; A61K31/55; C07C235/48; C07C235/50; C07C235/52; C07C237/22; C07C255/57; C07C257/18; C07C259/18; C07C271/20; C07C271/28; C07C275/40; C07C281/06; C07C311/37; C07D207/273; C07D211/76; C07D213/30; C07D231/12; C07D235/18; C07D235/26; C07D261/08; C07D263/10; C07D271/06; C07D277/56; C07D285/02; C07D295/155; C07D333/38; C07D403/10; C07D403/12; C07D471/04; C07D487/02; C07D491/02; C07F9/6506; C07F9/6561; C07D207/26; (IPC1-7): A61K31/55; A61K31/4745; A61K31/424; A61K31/421; A61K31/4196; A61K31/4184; C07D491/02; C07D487/02
Domestic Patent References:
| WO1999013061A1 | 1999-03-18 | |||
| WO2001096593A2 | 2001-12-20 | |||
| WO1998056756A1 | 1998-12-17 |
Foreign References:
| US6361993B1 | 2002-03-26 | |||
| US6331424B1 | 2001-12-18 | |||
| US6544766B1 | 2003-04-08 | |||
| US6440684B1 | 2002-08-27 | |||
| US6448025B1 | 2002-09-10 | |||
| US6355466B1 | 2002-03-12 | |||
| US6387644B1 | 2002-05-14 | |||
| US6461855B1 | 2002-10-08 | |||
| US6492151B1 | 2002-12-10 | |||
| US6617115B1 | 2003-09-09 | |||
| US6420561B1 | 2002-07-16 |
Other References:
T. HIGUCHI; V. STELLA: "Bioreversible Carriers in Drug Design", vol. 14, 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS, article "Pro-drugs as Novel Delivery Systems, Vol. 14 of the A.C.S. Symposium Series"
"Design of Prodrugs", 1985, ELSEVIER
YEN ET AL., NATURE, vol. 359, no. 6395, 1992, pages 536 - 9
THROWER ET AL., EMBO J., vol. 14, 1995, pages 918 - 26
WOOD ET AL., CELL, vol. 91, 1997, pages 357 - 66
See also references of EP 1742907A4
"Design of Prodrugs", 1985, ELSEVIER
YEN ET AL., NATURE, vol. 359, no. 6395, 1992, pages 536 - 9
THROWER ET AL., EMBO J., vol. 14, 1995, pages 918 - 26
WOOD ET AL., CELL, vol. 91, 1997, pages 357 - 66
See also references of EP 1742907A4
Attorney, Agent or Firm:
Garrett, Arthur S. (Henderson Farabow, Garrett & Dunner, LLP,
901 New York Avenue, N, Washington DC, US)
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