Title:
CHAGAS DISEASE VACCINE ANTIGENS WITH IMPROVED STABILITY AND DECREASED AGGREGATION
Document Type and Number:
WIPO Patent Application WO/2021/076570
Kind Code:
A3
Abstract:
Provided herein are compositions and methods for the prevention and treatment of Chagas disease and acute and chronic symptoms thereof. The compositions comprise recombinant proteins based on an amino terminal fragment of the TSA-1 protein from Trypanosoma cruzi. In the fragment, one or more Cys residues is mutated to prevent the formation of disulfide bonds and to enhance solubility. The recombinant proteins also include a carboxyl terminal fragment of the TSA-1 protein from Trypanosoma cruzi to provide additional stability and solubility. The resulting recombinant protein remains soluble upon prolonged storage at low temperatures and elicits a robust immune response upon administration, including decreasing the number of inflammatory cells in heart tissue of subjects.
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Inventors:
ZHAN BIN (US)
HOTEZ PETER (US)
BOTAZZI MARIA (US)
MORTEGA LÓPEZ JAIME (MX)
HOTEZ PETER (US)
BOTAZZI MARIA (US)
MORTEGA LÓPEZ JAIME (MX)
Application Number:
PCT/US2020/055504
Publication Date:
May 27, 2021
Filing Date:
October 14, 2020
Export Citation:
Assignee:
BAYLOR COLLEGE MEDICINE (US)
International Classes:
C07K14/44; A61K39/00; A61P37/02
Domestic Patent References:
| WO2017160849A1 | 2017-09-21 | |||
| WO2004067040A1 | 2004-08-12 |
Attorney, Agent or Firm:
WHITHAM, Michael, E. (US)
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