Title:
CHIMERIC ANTIGEN RECEPTOR CAR OR CAR CONSTRUCT TARGETING BCMA AND CD19 AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/007650
Kind Code:
A1
Abstract:
Provided are a chimeric antigen receptor (CAR) or CAR construct containing antibodies against BCMA and CD19, a nucleic acid molecule encoding the CAR or CAR construct, a modified immune cell, and a method for preparing the immune cell. The CAR or CAR construct and the modified immune cell are used for the prevention and/or treatment of B cell related conditions (e.g. B cell and plasma cell related malignant tumours or autoimmune diseases (such as systemic lupus erythematosus)), and can effectively avoid target escape and prevent the recurrence of multiple myeloma.
More Like This:
Inventors:
CHANG JIANHUI (CN)
ZHU YANLIN (CN)
JING GUANGJUN (CN)
WANG JINGYI (CN)
WANG JIANGMAN (CN)
CAI ZHENZHEN (CN)
HOU PANYAN (CN)
XIAO LIANG (CN)
XUE TONGTONG (CN)
WANG XIAODONG (CN)
ZHU YANLIN (CN)
JING GUANGJUN (CN)
WANG JINGYI (CN)
WANG JIANGMAN (CN)
CAI ZHENZHEN (CN)
HOU PANYAN (CN)
XIAO LIANG (CN)
XUE TONGTONG (CN)
WANG XIAODONG (CN)
Application Number:
PCT/CN2021/102417
Publication Date:
January 13, 2022
Filing Date:
June 25, 2021
Export Citation:
Assignee:
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07K16/46; A61K35/17; A61P35/00; A61P35/02; C07K16/28; C07K19/00; C12N5/07; C12N15/11; C12N15/63
Domestic Patent References:
| WO2020061796A1 | 2020-04-02 | |||
| WO2019099639A1 | 2019-05-23 |
Foreign References:
| CN109468283A | 2019-03-15 | |||
| CN109485734A | 2019-03-19 | |||
| CN110923255A | 2020-03-27 |
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
Download PDF:
Previous Patent: MESSAGE PROCESSING METHOD AND APPARATUS
Next Patent: DATA PROTECTION METHOD AND APPARATUS, AND SERVER AND MEDIUM
Next Patent: DATA PROTECTION METHOD AND APPARATUS, AND SERVER AND MEDIUM