Title:
CHIMERIC ANTIGEN RECEPTOR COMPRISING ANTI C-MET ANTIBODY OR ANTIGEN BINDING FRAGMENT THEREOF, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/060932
Kind Code:
A1
Abstract:
The present invention relates to a chimeric antigen receptor comprising a c-Met binding domain, and a use thereof. The chimeric antigen receptor comprising a c-Met binding domain, of the present invention, can be effectively usable as an agent for treating various diseases associated with c-Met expression.
Inventors:
CHAE JIN-A (KR)
YU SEUNG SHIN (KR)
YU SEUNG SHIN (KR)
Application Number:
PCT/KR2020/013127
Publication Date:
April 01, 2021
Filing Date:
September 25, 2020
Export Citation:
Assignee:
HELIXMITH CO LTD (KR)
International Classes:
C07K16/28; A61K35/17; A61P35/00; C07K14/725; C12N5/0783
Foreign References:
| CN106008721A | 2016-10-12 | |||
| KR20160017918A | 2016-02-17 | |||
| CN108707198A | 2018-10-26 | |||
| KR20180102116A | 2018-09-14 | |||
| CN108341881A | 2018-07-31 | |||
| KR20190119148A | 2019-10-21 | |||
| US4554101A | 1985-11-19 | |||
| KR20180140196A | 2018-11-14 | |||
| US6451595B1 | 2002-09-17 |
Other References:
"Cellular and Molecular Immunology", 1991, W. B. SAUNDERS CO. PHILADELPHIA, pages: 41 - 50
NISONOFF, A.: "Introduction to Molecular Immunology", vol. 4, 1984, SINAUER ASSOCIATES, INC., pages: 45 - 65
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1987, NATIONAL INSTITUTES OF HEALTH
DEAN ET AL., NATURE, vol. 4, no. 318, 1985, pages 6044
PARK ET AL., PNAS, vol. 84, no. 18, 1976, pages 6379
MAGGIORA ET AL., J. CELL PHYSIOL., vol. 173, 1997, pages 183
H. NEURATHR. L. HILL: "The Proteins", 1979, ACADEMIC PRESS
SCHEIT: "Nucleotide Analogs", 1980, JOHN WILEY
UHLMANPEYMAN, CHEMICAL REVIEWS, vol. 90, 1990, pages 543 - 584
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMANWUNSCH, J. MOL. BIO., vol. 48, 1970, pages 443
PEARSONLIPMAN, METHODS IN MOL. BIOL., vol. 24, 1988, pages 307 - 31
HIGGINSSHARP, GENE, vol. 73, 1988, pages 237 - 44
HIGGINSSHARP, CABIOS, vol. 5, 1989, pages 151 - 3
CORPET ET AL., NUC. ACIDS RES., vol. 16, 1988, pages 10881 - 90
HUANG ET AL., COMP. APPL. BIOSCI., vol. 8, 1992, pages 155 - 65
PEARSON ET AL., METH. MOL. BIOL., vol. 24, 1994, pages 307 - 31
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
ROSENBERG ET AL., NEW ENG. J. OF MED., vol. 319, 1988, pages 1676
See also references of EP 4039703A4
NISONOFF, A.: "Introduction to Molecular Immunology", vol. 4, 1984, SINAUER ASSOCIATES, INC., pages: 45 - 65
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1987, NATIONAL INSTITUTES OF HEALTH
DEAN ET AL., NATURE, vol. 4, no. 318, 1985, pages 6044
PARK ET AL., PNAS, vol. 84, no. 18, 1976, pages 6379
MAGGIORA ET AL., J. CELL PHYSIOL., vol. 173, 1997, pages 183
H. NEURATHR. L. HILL: "The Proteins", 1979, ACADEMIC PRESS
SCHEIT: "Nucleotide Analogs", 1980, JOHN WILEY
UHLMANPEYMAN, CHEMICAL REVIEWS, vol. 90, 1990, pages 543 - 584
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMANWUNSCH, J. MOL. BIO., vol. 48, 1970, pages 443
PEARSONLIPMAN, METHODS IN MOL. BIOL., vol. 24, 1988, pages 307 - 31
HIGGINSSHARP, GENE, vol. 73, 1988, pages 237 - 44
HIGGINSSHARP, CABIOS, vol. 5, 1989, pages 151 - 3
CORPET ET AL., NUC. ACIDS RES., vol. 16, 1988, pages 10881 - 90
HUANG ET AL., COMP. APPL. BIOSCI., vol. 8, 1992, pages 155 - 65
PEARSON ET AL., METH. MOL. BIOL., vol. 24, 1994, pages 307 - 31
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
ROSENBERG ET AL., NEW ENG. J. OF MED., vol. 319, 1988, pages 1676
See also references of EP 4039703A4
Attorney, Agent or Firm:
KONG, Byung-Wook (KR)
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