Title:
CHIMERIC ANTIGEN RECEPTOR MOLECULE FOR SPECIFICALLY RECOGNIZING BAFF-R AND APPLICATION OF CHIMERIC ANTIGEN RECEPTOR MOLECULE
Document Type and Number:
WIPO Patent Application WO/2022/242710
Kind Code:
A1
Abstract:
The present application discloses a chimeric antigen receptor molecule for specifically recognizing BAFF-R, a nucleic acid encoding the receptor molecule, an engineered immune effector cell comprising the receptor molecule, a pharmaceutical composition, and a use thereof. The receptor molecule comprises a structural domain that specifically recognizes the BAFF-R and an activation stimulation structural domain, and can activate a downstream signal path after specifically recognizing and binding the BAFF-R, thereby causing, promoting or improving an immune response reaction for the BAFF-R, and finally achieving the purpose of treating or preventing diseases caused by B cell BAFF-BAFF-R signal path imbalance.
More Like This:
| JP2023550628 | Antigen binding molecules and their uses |
| JPH0794480 | [Title of Invention] Antibody and its production method |
| JP2000515733 | [Title of Invention] Chemokine β-15 |
Inventors:
ZHANG XINMIN (CN)
NIAN WEIHONG (CN)
XU CHUANYING (CN)
HE FENG (CN)
ZHOU QING (CN)
ZHANG JIANBING (CN)
NIAN WEIHONG (CN)
XU CHUANYING (CN)
HE FENG (CN)
ZHOU QING (CN)
ZHANG JIANBING (CN)
Application Number:
PCT/CN2022/093782
Publication Date:
November 24, 2022
Filing Date:
May 19, 2022
Export Citation:
Assignee:
SHANGHAI ESCUGEN BIOTECHNOLOGY CO LTD (CN)
GUANGZHOU YINNUOLAI BIOTECHNOLOGY CO LTD (CN)
GUANGZHOU YINNUOLAI BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K16/24; A61K35/17; A61P35/00; C12N5/10; C12N15/13
Domestic Patent References:
| WO2021168169A1 | 2021-08-26 | |||
| WO2021163989A1 | 2021-08-26 | |||
| WO1993011161A1 | 1993-06-10 |
Foreign References:
| CN101851291A | 2010-10-06 | |||
| CN112292137A | 2021-01-29 | |||
| US20190201442A1 | 2019-07-04 | |||
| EP0404097A2 | 1990-12-27 | |||
| US5641870A | 1997-06-24 | |||
| US20210261676A1 | 2021-08-26 |
Other References:
DONG ZHENYUAN; CHENG WESLEY A.; SMITH D. LYNNE; HUANG BRIAN; ZHANG TIANTIAN; CHANG WEN-CHUNG; WANG XIULI; FORMAN STEPHEN J.; KWAK : "Antitumor efficacy of BAFF-R targeting CAR T cells manufactured under clinic-ready conditions", CANCER IMMUNOLOGY IMMUNOTHERAPY, SPRINGER, BERLIN/HEIDELBERG, vol. 69, no. 10, 25 May 2020 (2020-05-25), Berlin/Heidelberg , pages 2139 - 2145, XP037253279, ISSN: 0340-7004, DOI: 10.1007/s00262-020-02614-8
L M QIN, QIN HONG, DONG ZHENYUAN, WANG XIULI, CHENG WESLEY A, WEN FENG, XUE WEILI, SUN HAN, WALTER MIRIAM, WEI GUOWEI, SMITH D LYN: "CAR T cells targeting BAFF-R can overcome CD19 antigen loss in B cell malignancies", SCI. TRANSL. MED, 25 September 2019 (2019-09-25), XP055706529, Retrieved from the Internet [retrieved on 20200618], DOI: 10.1126/scitranslmed.aaw9414
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", vol. 1-3, 1991, NIH PUBLICATION 91-3242
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PNAS(USA, vol. 85, 1988, pages 5879 - 5883
HOLLINGER ET AL., PROC. NATL .ACAD.SCI.USA, vol. 90, 1993, pages 6444 - 6448
ZAPATA ET AL., PROTEIN ENG., vol. 8, no. 10, 1995, pages 1057 - 1062
"Remington: The Science and Practice of Pharmacy", 2012, PHARMACEUTICAL PRESS
L M QIN, QIN HONG, DONG ZHENYUAN, WANG XIULI, CHENG WESLEY A, WEN FENG, XUE WEILI, SUN HAN, WALTER MIRIAM, WEI GUOWEI, SMITH D LYN: "CAR T cells targeting BAFF-R can overcome CD19 antigen loss in B cell malignancies", SCI. TRANSL. MED, 25 September 2019 (2019-09-25), XP055706529, Retrieved from the Internet
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", vol. 1-3, 1991, NIH PUBLICATION 91-3242
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PNAS(USA, vol. 85, 1988, pages 5879 - 5883
HOLLINGER ET AL., PROC. NATL .ACAD.SCI.USA, vol. 90, 1993, pages 6444 - 6448
ZAPATA ET AL., PROTEIN ENG., vol. 8, no. 10, 1995, pages 1057 - 1062
"Remington: The Science and Practice of Pharmacy", 2012, PHARMACEUTICAL PRESS
Attorney, Agent or Firm:
BEIJING TANGSONG IP FIRM (CN)
Download PDF: