Title:
CHIMERIC ANTIGEN RECEPTOR TARGETING CS1, BISPECIFIC CHIMERIC ANTIGEN RECEPTOR TARGETING BCMA/CS1 AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/125766
Kind Code:
A1
Abstract:
The present invention provides a chimeric antigen receptor targeting CS1, comprising an extracellular antigen recognition domain, a hinge region, a transmembrane region and an intracellular domain, wherein the extracellular antigen recognition domain comprises an scFv antibody against CS1; amino acid sequences of VH complementarity determining regions CDR1, CDR2 and CDR3 of the scFv antibody respectively comprise amino acid sequences as shown in SEQ ID NO: 1, SEQ ID NO: 2 and SEQ ID NO: 3; and amino acid sequences of VL complementarity determining regions CDR1, CDR2 and CDR3 of the scFv antibody respectively comprise amino acid sequences as shown in SEQ ID NO: 4, SEQ ID NO: 5 and SEQ ID NO: 6.
Inventors:
ZHANG CHAO (CN)
DING WEI (CN)
ZHANG QIMENG (CN)
LV LULU (CN)
ZHOU LI (CN)
WANG YONGZENG (CN)
ZHANG YUNLONG (CN)
BAI DAYONG (CN)
LU JIAXING (CN)
DING WEI (CN)
ZHANG QIMENG (CN)
LV LULU (CN)
ZHOU LI (CN)
WANG YONGZENG (CN)
ZHANG YUNLONG (CN)
BAI DAYONG (CN)
LU JIAXING (CN)
Application Number:
PCT/CN2022/143236
Publication Date:
July 06, 2023
Filing Date:
December 29, 2022
Export Citation:
Assignee:
JUVENTAS CELL THERAPY LTD (CN)
International Classes:
C07K19/00; A61K35/17; A61K39/395; A61P35/00; A61P37/06; C07K16/24; C07K16/46; C12N5/10; C12N15/62; C12N15/63
Domestic Patent References:
| WO2020009868A1 | 2020-01-09 | |||
| WO2021045975A1 | 2021-03-11 |
Foreign References:
| CN107429253A | 2017-12-01 | |||
| CN112566643A | 2021-03-26 | |||
| CN112778427A | 2021-05-11 |
Attorney, Agent or Firm:
PEKSUNG INTELLECTUAL PROPERTY LTD. (CN)
Download PDF: