CHOLESTEROL-LOWERING AGENTS AS TREATMENT FOR PSYCHOLOGICAL AND COGNITIVE DISORDERS

Title:

CHOLESTEROL-LOWERING AGENTS AS TREATMENT FOR PSYCHOLOGICAL AND COGNITIVE DISORDERS

Document Type and Number:

WIPO Patent Application WO2002062300

Kind Code:

A3

Abstract:

Provided are methods for treating a membrane fluidity-related conginitive or psychological disorder in a human patient. The methods include the steps of: (a) performing a diagnostic test on the patient to determine that the patient has a cognitive or psychological disorder, and (b) administering to the patient a cholesterol-lowering agent in an amount sufficient to lower the serum choloesterol of the patient enough to increase brain membrane fluidity adequately to treat the cognitive or psychological disorder.

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Inventors:

RENSHAW PERRY F (US)
COHEN BRUCE M (US)

Application Number:

PCT/US2002/003668

Publication Date:

October 24, 2002

Filing Date:

February 07, 2002

Export Citation:

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Assignee:

MCLEAN HOSPITAL CORP (US)
RENSHAW PERRY F (US)
COHEN BRUCE M (US)

International Classes:

A61K31/195; A61K31/205; A61K31/225; A61K31/335; A61K31/34; A61K31/366; A61K31/40; A61K31/401; (IPC1-7): A61K31/40; A61K31/335; A61K31/34; A61K31/205; A61K31/195

Foreign References:

US20010028895A1	2001-10-11
US6274603B1	2001-08-14
US6080778A	2000-06-27

Other References: