Title:
METHOD AND COMPOSITION FOR REJUVINATING CELLS, TISSUES, ORGANS, HAIR AND NAILS
Document Type and Number:
WIPO Patent Application WO2002062301
Kind Code:
A3
Abstract:
In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomaterials, and any combination thereof. In another embodiment, the compositions and associated methods have utility in vivo to reduce the deleterious effects of sugar-mediated coupling processes in an organism, when the organism is exposed to the compound or composition internally, by ingestion, transdermal application, or other means. In yet another embodiment, the compositions and associated methods are useful for the ex-vivo treatment of organs, cells and tissues and external treatment of hair, nails and skin to rejuvenate them by changing deformability and increase the tissue fissuion coefficient. In a further embodiment, the present invention relates to novel compounds and pharmaceutical compositions.
Inventors:
ULRICH PETER C (US)
FANG SHENG DING
BRINES MICHAEL (US)
XIE QIAO WEN (US)
CERAMI ANTHONY (US)
FANG SHENG DING
BRINES MICHAEL (US)
XIE QIAO WEN (US)
CERAMI ANTHONY (US)
Application Number:
PCT/US2002/003714
Publication Date:
October 17, 2002
Filing Date:
February 07, 2002
Export Citation:
Assignee:
FARRINGTON PHARMACEUTICALS LLC (US)
ULRICH PETER C (US)
FANG SHENG DING
BRINES MICHAEL (US)
XIE QIAO WEN (US)
CERAMI ANTHONY (US)
ULRICH PETER C (US)
FANG SHENG DING
BRINES MICHAEL (US)
XIE QIAO WEN (US)
CERAMI ANTHONY (US)
International Classes:
C07D233/60; A61K8/49; A61K31/415; A61K31/4174; A61K31/425; A61K31/426; A61K31/427; A61K31/428; A61K31/44; A61K31/452; A61K31/495; A61K31/496; A61K31/50; A61K31/505; A61K31/519; A61K31/535; A61K31/5377; A61K31/5383; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P13/02; A61P13/12; A61P17/00; A61P19/02; A61P25/02; A61P25/28; A61P27/02; A61P27/12; A61P27/16; A61P43/00; A61Q3/00; A61Q3/02; A61Q5/00; A61Q5/12; A61Q19/00; A61Q19/08; C07D213/20; C07D213/50; C07D213/57; C07D213/73; C07D233/54; C07D239/26; C07D239/42; C07D265/36; C07D277/22; C07D277/24; C07D277/84; C07D417/06; C07D487/04; C07D498/02; C07D513/04; C07D521/00; (IPC1-7): A61K31/425; A61K31/415; A61K31/44; A61K31/495; A61K31/50; A61K31/505; A61K31/535; C07D213/02; C07D233/54; C07D239/02; C07D277/20; C07D277/30; C07D277/60; C07D401/00; C07D403/02; C07D413/02; C07D417/00; C07D498/02
Other References:
SCOZZAFAVA ET AL.: "Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, no. 2, 27 January 2000 (2000-01-27), pages 292, 294 - 300, XP002953423
DIAZ ET AL.: "Regioselectivity in the Westphal condensation", JOURNAL OF ORGANIC CHEMISTRY, vol. 59, no. 26, 1994, pages 8294 - 8296, XP002953469
ULRICH ET AL.: "Potential antitrypanosomal agents. 1,N2-disubstituted 2-amino-5-hydroxy-4-methylnaphtho(1,2-d)thiazolium salts and related compounds", JOURNAL OF MEDICINAL CHEMISTRY, vol. 25, no. 6, 1982, pages 654 - 657, XP000574885
See also references of EP 1368029A4
DIAZ ET AL.: "Regioselectivity in the Westphal condensation", JOURNAL OF ORGANIC CHEMISTRY, vol. 59, no. 26, 1994, pages 8294 - 8296, XP002953469
ULRICH ET AL.: "Potential antitrypanosomal agents. 1,N2-disubstituted 2-amino-5-hydroxy-4-methylnaphtho(1,2-d)thiazolium salts and related compounds", JOURNAL OF MEDICINAL CHEMISTRY, vol. 25, no. 6, 1982, pages 654 - 657, XP000574885
See also references of EP 1368029A4
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