Title:
A CLASS OF ARYL GLUCOSIDE DERIVATIVES, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/227440
Kind Code:
A1
Abstract:
Provided are a compound that inhibits sodium-glucose co-transporter 1, and a pharmaceutically acceptable salt and stereoisomer thereof. The compound is used in a pharmaceutical composition and preparation and usage methods, which comprise an application of a drug and composition thereof in the preparation for treating and improving diabetes, cardiovascular and cerebrovascular diseases, weight loss, fatty liver disease, constipation, metabolism-related diseases and tumor treatment.
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Inventors:
ZHANG QIANG (CN)
DU FENGTIAN (CN)
WANG HAIBO (CN)
DU FENGTIAN (CN)
WANG HAIBO (CN)
Application Number:
PCT/CN2020/131249
Publication Date:
November 18, 2021
Filing Date:
November 24, 2020
Export Citation:
Assignee:
SHANGHAI ZHEYE BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07H15/14; A61K31/351; A61K31/395; A61P1/00; A61P1/16; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/12; A61P35/00
Domestic Patent References:
| WO2014081660A1 | 2014-05-30 |
Foreign References:
| CN108610385A | 2018-10-02 | |||
| CN110117300A | 2019-08-13 | |||
| CN106892948A | 2017-06-27 | |||
| CN110092768A | 2019-08-06 |
Other References:
MURILLO BEATRIZ; ZORNOZA BEATRIZ; DE LA IGLESIA OSCAR; TéLLEZ CARLOS; CORONAS JOAQUíN: "Chemocatalysis of sugars to produce lactic acid derivatives on zeolitic imidazolate frameworks", JOURNAL OF CATALYSIS, ACADEMIC PRESS, DULUTH, MN., US, vol. 334, 17 December 2015 (2015-12-17), US , pages 60 - 67, XP029391131, ISSN: 0021-9517, DOI: 10.1016/j.jcat.2015.11.016
LAUREN E. SIROIS, MATTHEW M. ZHAO, NGIAP-KIE LIM, MARK S. BEDNARZ, BRYCE A. HARRISON, WENXUE WU: "Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp 3 –sp 2 Suzuki Coupling of a Benzyl Carbonate", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 23, no. 1, 18 January 2019 (2019-01-18), US , pages 45 - 61, XP055636549, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.8b00325
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JOURNAL OF FLUORESCENCE, vol. 23, no. 1, 2013, pages 181 - 186
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ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 58, no. 21, 2019, pages 6987 - 6992
CHEMISCHE BERICHTE, vol. 118, no. 4, 1985, pages 1564 - 1574
SCIENCE OF SYNTHESIS, vol. 41, 2010, pages 543 - 612
NATURE, vol. 574, no. 7776, 2019, pages 86 - 89
ACTA PHARMACEUTICA SINICA, vol. 52, no. 6, 2017, pages 897 - 903
NATURE PROTOCOLS, vol. 2, no. 3, 2007, pages 753 - 762
JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, vol. 64, no. 3, 2005, pages 207 - 215
DIABETES TECHNOLOGY & THERAPEUTICS, vol. 13, no. 7, 2011, pages 743 - 775
CAS , no. 186689-07-6
LAUREN E. SIROIS, MATTHEW M. ZHAO, NGIAP-KIE LIM, MARK S. BEDNARZ, BRYCE A. HARRISON, WENXUE WU: "Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp 3 –sp 2 Suzuki Coupling of a Benzyl Carbonate", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 23, no. 1, 18 January 2019 (2019-01-18), US , pages 45 - 61, XP055636549, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.8b00325
JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, 2017, pages 710 - 721
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, no. 20, 2014, pages 7205 - 7208
CHEMISTRY - A EUROPEAN JOURNAL, vol. 17, no. 12, 2011, pages 3326 - 3331
JOURNAL OF FLUORESCENCE, vol. 23, no. 1, 2013, pages 181 - 186
JOURNAL OF ORGANIC CHEMISTRY, vol. 76, no. 12, 2011, pages 4964 - 4972
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 58, no. 21, 2019, pages 6987 - 6992
CHEMISCHE BERICHTE, vol. 118, no. 4, 1985, pages 1564 - 1574
SCIENCE OF SYNTHESIS, vol. 41, 2010, pages 543 - 612
NATURE, vol. 574, no. 7776, 2019, pages 86 - 89
ACTA PHARMACEUTICA SINICA, vol. 52, no. 6, 2017, pages 897 - 903
NATURE PROTOCOLS, vol. 2, no. 3, 2007, pages 753 - 762
JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, vol. 64, no. 3, 2005, pages 207 - 215
DIABETES TECHNOLOGY & THERAPEUTICS, vol. 13, no. 7, 2011, pages 743 - 775
CAS , no. 186689-07-6
Attorney, Agent or Firm:
SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)
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