Title:
CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX EXPRESSION ENHANCING COMPOUND, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/241809
Kind Code:
A1
Abstract:
Disclosed in the present invention are a class II major histocompatibility complex (MHC class Ⅱ) expression enhancing compound, and a preparation method therefor and an application thereof. In the present application, experiments prove that the compound has a remarkable effect in enhancing MHC class Ⅱ expression, a remarkable effect in enhancing MHC class Ⅱ tumor neoantigen presentation and promoting tumor tissue CD4+T cell infiltration, and a remarkable effect in inhibiting tumor growth when the compound is used independently or in combination with existing immunotherapy means drugs.
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Inventors:
CHEN LIMING (CN)
HUANG LING (CN)
LI LULU (CN)
XIE LANGUI (CN)
WEI BO (CN)
HUANG LING (CN)
LI LULU (CN)
XIE LANGUI (CN)
WEI BO (CN)
Application Number:
PCT/CN2021/096010
Publication Date:
November 24, 2022
Filing Date:
May 26, 2021
Export Citation:
Assignee:
STAR PHARMACEUTICAL NANJING INC (CN)
International Classes:
C07C69/78; A61K31/01; A61K31/075; A61K31/08; A61K31/10; A61K31/19; A61K31/235; A61K31/496; A61P35/00; A61P37/02; C07C1/20; C07C9/22; C07C43/04; C07C43/178; C07C59/125; C07C69/84; C07C321/14; C07D241/04
Foreign References:
| CN111214462A | 2020-06-02 | |||
| CN104961617A | 2015-10-07 |
Other References:
MALAR, S. S. S , BEULA, J. M. , MENAGA MAGENDRAN: "Computational Screening of the Active Compounds Isolated from the Macro Algae Valaniopsis Pachynema, against AKT1, a Cancer Drug Target Protein.", JOURNAL OF CHEMICAL AND PHARMACEUTICAL RESEARCH, vol. 6, no. 12, 31 December 2014 (2014-12-31), ISSN: 0975-7384
HOLMBERG JENS, TUNCEL JONATAN, YAMADA HISAKATA, LU SHEMIN, OLOFSSON PETER, HOLMDAHL RIKARD: "Pristane, a Non-Antigenic Adjuvant, Induces MHC Class II-Restricted, Arthritogenic T Cells in the Rat", THE JOURNAL OF IMMUNOLOGY, vol. 176, no. 2, 15 January 2006 (2006-01-15), US , pages 1172 - 1179, XP093007252, ISSN: 0022-1767, DOI: 10.4049/jimmunol.176.2.1172
FERIT AVCU; ALI UGUR URAL; MAHMUT ILKER YILMAZ; AYHAN OZCAN; TAYFUN IDE; BULENT KURT; ATILLA YALCIN: "The bisphosphonate zoledronic acid inhibits the development of plasmacytoma induced in BALB/c mice by intraperitoneal injection of pristane", EUROPEAN JOURNAL OF HAEMATOLOGY, vol. 74, no. 6, 5 May 2005 (2005-05-05), DK , pages 496 - 500, XP071758649, ISSN: 0902-4441, DOI: 10.1111/j.1600-0609.2005.00427.x
HOLMBERG JENS, TUNCEL JONATAN, YAMADA HISAKATA, LU SHEMIN, OLOFSSON PETER, HOLMDAHL RIKARD: "Pristane, a Non-Antigenic Adjuvant, Induces MHC Class II-Restricted, Arthritogenic T Cells in the Rat", THE JOURNAL OF IMMUNOLOGY, vol. 176, no. 2, 15 January 2006 (2006-01-15), US , pages 1172 - 1179, XP093007252, ISSN: 0022-1767, DOI: 10.4049/jimmunol.176.2.1172
FERIT AVCU; ALI UGUR URAL; MAHMUT ILKER YILMAZ; AYHAN OZCAN; TAYFUN IDE; BULENT KURT; ATILLA YALCIN: "The bisphosphonate zoledronic acid inhibits the development of plasmacytoma induced in BALB/c mice by intraperitoneal injection of pristane", EUROPEAN JOURNAL OF HAEMATOLOGY, vol. 74, no. 6, 5 May 2005 (2005-05-05), DK , pages 496 - 500, XP071758649, ISSN: 0902-4441, DOI: 10.1111/j.1600-0609.2005.00427.x
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM ( ORDINARY PARTNERSHIP ) (CN)
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