Title:
COMBINATION THERAPY FOR CANCER USING AZABICYCLIC COMPOUND AND POLY(ADENOSINE 5'-DIPHOSPHATE-RIBOSE) POLYMERASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2021/025065
Kind Code:
A1
Abstract:
Provided is a novel cancer therapy having a high antitumor effect. This antitumor agent is characterized in that an azabicyclic compound represented by general formula (I) or a salt thereof and a poly(adenosine 5'-diphosphate-ribose) polymerase inhibitor are administered in combination.
Inventors:
MURAOKA HIROMI (JP)
ARIMURA NAOKI (JP)
ARIMURA NAOKI (JP)
Application Number:
PCT/JP2020/030017
Publication Date:
February 11, 2021
Filing Date:
August 05, 2020
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/437; A61K31/4184; A61K31/4462; A61K31/517; A61K31/519; A61K31/5517; A61K45/00; A61P35/00
Domestic Patent References:
| WO2015046498A1 | 2015-04-02 |
Other References:
RASHID GABBASOV, I. DANIEL BENRUBI, SHANE W. O’BRIEN, JOHN J. KRAIS, NEIL JOHNSON, SAMUEL LITWIN, DENISE C. CONNOLLY: "Targeted blockade of HSP90 impairs DNA-damage response proteins and increases the sensitivity of ovarian carcinoma cells to PARP inhibition", CANCER BIOLOGY & THERAPY, LANDES BIOSCIENCE, US, vol. 20, no. 7, 3 July 2019 (2019-07-03), US, pages 1035 - 1045, XP055622540, ISSN: 1538-4047, DOI: 10.1080/15384047.2019.1595279
KONSTANTINOPOULOS P., ET AL.: "In vivo synergism between PARP-inhibitor olaparib and HSP90 inhibitor AT 13387 in high grade serous ovarian cancer patient derived xenografts", JOURNAL OF CLINICAL ONCOLOGY, vol. 34, no. 15, 20 May 2016 (2016-05-20), pages e17045, XP055790900
KONSTANTINOPOULOS P., ET AL.: "In vivo synergism between PARP-inhibitor olaparib and HSP90 inhibitor AT 13387 in high grade serous ovarian cancer patient derived xenografts", JOURNAL OF CLINICAL ONCOLOGY, vol. 34, no. 15, 20 May 2016 (2016-05-20), pages e17045, XP055790900
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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