Title:
COMMERCIAL PURIFICATION METHOD FOR HIGH-PURITY BACTERIAL EXTRACELLULAR VESICLES
Document Type and Number:
WIPO Patent Application WO/2022/270872
Kind Code:
A1
Abstract:
The present invention relates to a method for mass purifying high-purity bacterial extracellular vesicles and, more specifically, the present invention relates to a method for quickly and conveniently isolating and purifying high-purity bacterial extracellular vesicles from a large amount of bacterial cell culture product by means of calcium or cobalt. The purification method of the present invention is appropriate for obtaining high-purity bacterial extracellular vesicles in a commercial scale by treating a large amount of bacterial cell culture product and, particularly, when using calcium which is innocuous to the human body, is more advantageous in purifying bacterial extracellular vesicles to be used in a drug for human body.
Inventors:
LEE CHANG JIN (KR)
SONG SUNG HYUN (KR)
KIM SI WON (KR)
LEE TAE RYONG (KR)
SONG SUNG HYUN (KR)
KIM SI WON (KR)
LEE TAE RYONG (KR)
Application Number:
PCT/KR2022/008791
Publication Date:
December 29, 2022
Filing Date:
June 21, 2022
Export Citation:
Assignee:
ROSETTA EXOSOME CO LTD (KR)
International Classes:
C12N1/20; B01D15/36
Domestic Patent References:
| WO2020191369A1 | 2020-09-24 |
Foreign References:
| KR20190012130A | 2019-02-08 | |||
| KR20200107981A | 2020-09-16 | |||
| KR101875594B1 | 2018-07-06 | |||
| KR20120023684A | 2012-03-13 | |||
| KR101752506B1 | 2017-06-30 |
Other References:
MOMEN-HERAVI ET AL., METHODS MOL. BIOL., vol. 1660, 2017, pages 25 - 32
GAMEZ-VALERO ET AL., SCI. REP., vol. 6, 2016, pages 33641
NIU ET AL., PLOS ONE, 2017, pages 0186534
GAMEZ-VALERO ET AL., SCI. REP., vol. 6, 2016, pages 33641
NIU ET AL., PLOS ONE, 2017, pages 0186534
Attorney, Agent or Firm:
GURU IP LAW FIRM (KR)
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