Title:
COMPLEX CONTAINING NEURAL RETINA-CONTAINING CELL AGGREGATES AND MATRIX, AND METHOD FOR MANUFACTURING SAME
Document Type and Number:
WIPO Patent Application WO/2022/054925
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a complex containing two or more neural retina-containing cell aggregates and a matrix, and a method for manufacturing the same. The complex according to the present invention contains two or more cell aggregates, which contain pluripotent stem cell-derived neural retinas, and a matrix, where the two or more cell aggregates are disposed inside the matrix. The method for manufacturing the complex according to the present invention is a method for manufacturing a complex in which two or more neural retina-containing cell aggregates are disposed inside a matrix, the method including: (1) a first step for producing the two or more neural retina cell aggregates from pluripotent stem cells, and (2) a second step for making the matrix into a gel by causing the two or more cell aggregates to come into contact with the matrix or a matrix precursor in a prescribed arrangement.
Inventors:
MANDAI MICHIKO (JP)
TAKAHASHI MASAYO (JP)
YAMASAKI SUGURU (JP)
TAKAHASHI MASAYO (JP)
YAMASAKI SUGURU (JP)
Application Number:
PCT/JP2021/033387
Publication Date:
March 17, 2022
Filing Date:
September 10, 2021
Export Citation:
Assignee:
RIKEN (JP)
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
C12N5/0793; A61L27/22; A61L27/36; A61L27/38; A61L27/44; A61L27/52; A61L27/58; C12N5/0797
Domestic Patent References:
| WO2019028088A1 | 2019-02-07 | |||
| WO2015025967A1 | 2015-02-26 | |||
| WO2016063986A1 | 2016-04-28 | |||
| WO1996022362A1 | 1996-07-25 | |||
| WO2002101057A1 | 2002-12-19 | |||
| WO2011055855A1 | 2011-05-12 | |||
| WO2013077425A1 | 2013-05-30 | |||
| WO2016063985A1 | 2016-04-28 | |||
| WO2017183732A1 | 2017-10-26 | |||
| WO2019017492A1 | 2019-01-24 | |||
| WO2019054514A1 | 2019-03-21 | |||
| WO2019054515A1 | 2019-03-21 | |||
| WO1997021993A2 | 1997-06-19 | |||
| WO2004066929A2 | 2004-08-12 | |||
| WO2004093799A2 | 2004-11-04 | |||
| WO2000039077A2 | 2000-07-06 | |||
| WO2001098256A1 | 2001-12-27 | |||
| WO2003018515A2 | 2003-03-06 | |||
| WO2003084915A1 | 2003-10-16 | |||
| WO2002094319A1 | 2002-11-28 | |||
| WO2003064369A1 | 2003-08-07 | |||
| WO2007132475A1 | 2007-11-22 | |||
| WO2007009913A1 | 2007-01-25 | |||
| WO2003094845A2 | 2003-11-20 | |||
| WO2002051805A1 | 2002-07-04 | |||
| WO2010122980A1 | 2010-10-28 |
Foreign References:
| JP2016052271A | 2016-04-14 | |||
| US5843780A | 1998-12-01 | |||
| US6200806B1 | 2001-03-13 | |||
| US6280718B1 | 2001-08-28 | |||
| JP2002053564A | 2002-02-19 | |||
| JP2002370978A | 2002-12-24 | |||
| JP2000256190A | 2000-09-19 | |||
| JP2020011254W | 2020-03-13 |
Other References:
TAMER A. E. AHMED, RANDY RINGUETTE, VALERIE A. WALLACE, MAY GRIFFITH: "Autologous Fibrin Glue as an Encapsulating Scaffold for Delivery of Retinal Progenitor Cells", FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 2, XP055685326, DOI: 10.3389/fbioe.2014.00085
BEN M’BAREK KARIM, HABELER WALTER, PLANCHERON ALEXANDRA, JARRAYA MOHAMED, REGENT FLORIAN, TERRAY ANGÉLIQUE, YANG YING, CHATROUSSE : "Human ESC–derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration", SCIENCE TRANSLATIONAL MEDICINE, vol. 9, no. 421, 20 December 2017 (2017-12-20), pages 7471, XP055905294, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aai7471
ATSUSHI KUWAHARA, OZONE CHIKAFUMI, NAKANO TOKUSHIGE, SAITO KOICHI, EIRAKU MOTOTSUGU, SASAI YOSHIKI: "Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 6, 19 February 2015 (2015-02-19), UK, pages 6286, XP055371363, ISSN: 2041-1723, DOI: 10.1038/ncomms7286
ATSUSHI KUWAHARA ET AL.: "Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue", NATURE COMMUNICATIONS, vol. 6, 2015, XP055791403, DOI: 10.1038/ncomms7286
TAYLOR ET AL., IOVS, vol. 30, August 1989 (1989-08-01)
M' BAREK ET AL., SCI. TRANSL. MED, vol. 9, December 2017 (2017-12-01)
SEILER ET AL., PROG RETIN EYE RES, vol. 31, no. 6, November 2012 (2012-11-01), pages 661 - 687
TAMER A.E. AHMED ET AL.: "Frontiersin Bioengineering and Biotechnology", BIOMATERIALS, vol. 2, no. 85, February 2015 (2015-02-01), pages 1 - 11
YAMANAKA ET AL., CELL, vol. 126, no. 4, 2006, pages 663 - 676
CELL, vol. 131, no. 5, 2007, pages 861 - 872
SCIENCE, vol. 318, no. 5858, 2007, pages 1917 - 1920
NAT. BIOTECHNOL., vol. 26, no. 1, 2008, pages 101 - 106
BOUCHERIE, C ET AL., STEM CELLS, vol. 31, 2013, pages 408 - 414
SCIENCE, vol. 341, 2013, pages 651 - 654
PLOS ONE, vol. 5, no. 1, 20 January 2010 (2010-01-20), pages e8763
STEM CELLS, vol. 29, no. 8, August 2011 (2011-08-01), pages 1206 - 18
PROC NATL ACAD SCI USA., vol. 111, no. 23, 10 June 2014 (2014-06-10), pages 8518 - 23
NAT COMMUN., vol. 5, 10 June 2014 (2014-06-10), pages 4047
BRYCE T. MCLELLAND ET AL., IOVS, vol. 59, no. 6, May 2018 (2018-05-01), pages 2586
NAKANO, T. ET AL., CELL STEM CELL, vol. 10, 2012, pages 771 - 785
KAWAHARA A. ET AL., NATURE COMMUNICATIONS, vol. 6, 2015, pages 6286
KUWAHARA AYAMASAKI S ET AL., SCI REP, vol. 9, no. 1, 12 December 2019 (2019-12-12), pages 18936
LAMBA, D.A.GUST, JREH, T.A, CELL STEM CELL, vol. 4, 2009, pages 73 - 79
ZHU, J.CIFUENTES, HREYNOLDS, JLAMBA, D.A, CELL STEM CELL, vol. 20, no. 374-384, 2017, pages e375
MEYER, J.S. ET AL., STEM CELLS, vol. 29, 2011, pages 1206 - 1218
ZHONG, X. ET AL., NAT COMMUN, vol. 5, 2014
GONZALEZ-CORDERO, A. ET AL., NAT BIOTECHNOL, vol. 31, 2013, pages 741 - 747
MELLOUGH, C.B. ET AL., STEM CELLS, vol. 33, 2015, pages 2416 - 2430
HALLAM, D. ET AL., STEM CELLS, 2018
REICHMAN, S. ET AL., PNAS, vol. 111, 2014, pages 8518 - 8523
DISTEFANO, T. ET AL., STEM CELL REPORTS, vol. 10, 2018, pages 300 - 313
TUCKER, B.A ET AL., STEM CELLS TRANSL MED, vol. 2, 2013, pages 16 - 24
WAHLIN, K.J. ET AL., SCI REP, vol. 7, 2017, pages 766
NATURE METHODS, vol. 8, 2011, pages 424 - 429
PROC. NATL. ACAD. SCI. USA., vol. 105, no. 36, 9 September 2008 (2008-09-09), pages 13409 - 14
NAT BIOTECHNOL, vol. 28, 2010, pages 611 - 615
NAT COMMUN, vol. 3, 2012, pages 1236
NAT BIOTECHNOL, vol. 19, 2001, pages 971 - 974
"PAGI method", 2006, article "a method for testing photographic gelatin"
SHIRAI ET AL., PNAS, vol. 113, pages E81 - E90
See also references of EP 4206321A4
BEN M’BAREK KARIM, HABELER WALTER, PLANCHERON ALEXANDRA, JARRAYA MOHAMED, REGENT FLORIAN, TERRAY ANGÉLIQUE, YANG YING, CHATROUSSE : "Human ESC–derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration", SCIENCE TRANSLATIONAL MEDICINE, vol. 9, no. 421, 20 December 2017 (2017-12-20), pages 7471, XP055905294, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aai7471
ATSUSHI KUWAHARA, OZONE CHIKAFUMI, NAKANO TOKUSHIGE, SAITO KOICHI, EIRAKU MOTOTSUGU, SASAI YOSHIKI: "Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 6, 19 February 2015 (2015-02-19), UK, pages 6286, XP055371363, ISSN: 2041-1723, DOI: 10.1038/ncomms7286
ATSUSHI KUWAHARA ET AL.: "Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue", NATURE COMMUNICATIONS, vol. 6, 2015, XP055791403, DOI: 10.1038/ncomms7286
TAYLOR ET AL., IOVS, vol. 30, August 1989 (1989-08-01)
M' BAREK ET AL., SCI. TRANSL. MED, vol. 9, December 2017 (2017-12-01)
SEILER ET AL., PROG RETIN EYE RES, vol. 31, no. 6, November 2012 (2012-11-01), pages 661 - 687
TAMER A.E. AHMED ET AL.: "Frontiersin Bioengineering and Biotechnology", BIOMATERIALS, vol. 2, no. 85, February 2015 (2015-02-01), pages 1 - 11
YAMANAKA ET AL., CELL, vol. 126, no. 4, 2006, pages 663 - 676
CELL, vol. 131, no. 5, 2007, pages 861 - 872
SCIENCE, vol. 318, no. 5858, 2007, pages 1917 - 1920
NAT. BIOTECHNOL., vol. 26, no. 1, 2008, pages 101 - 106
BOUCHERIE, C ET AL., STEM CELLS, vol. 31, 2013, pages 408 - 414
SCIENCE, vol. 341, 2013, pages 651 - 654
PLOS ONE, vol. 5, no. 1, 20 January 2010 (2010-01-20), pages e8763
STEM CELLS, vol. 29, no. 8, August 2011 (2011-08-01), pages 1206 - 18
PROC NATL ACAD SCI USA., vol. 111, no. 23, 10 June 2014 (2014-06-10), pages 8518 - 23
NAT COMMUN., vol. 5, 10 June 2014 (2014-06-10), pages 4047
BRYCE T. MCLELLAND ET AL., IOVS, vol. 59, no. 6, May 2018 (2018-05-01), pages 2586
NAKANO, T. ET AL., CELL STEM CELL, vol. 10, 2012, pages 771 - 785
KAWAHARA A. ET AL., NATURE COMMUNICATIONS, vol. 6, 2015, pages 6286
KUWAHARA AYAMASAKI S ET AL., SCI REP, vol. 9, no. 1, 12 December 2019 (2019-12-12), pages 18936
LAMBA, D.A.GUST, JREH, T.A, CELL STEM CELL, vol. 4, 2009, pages 73 - 79
ZHU, J.CIFUENTES, HREYNOLDS, JLAMBA, D.A, CELL STEM CELL, vol. 20, no. 374-384, 2017, pages e375
MEYER, J.S. ET AL., STEM CELLS, vol. 29, 2011, pages 1206 - 1218
ZHONG, X. ET AL., NAT COMMUN, vol. 5, 2014
GONZALEZ-CORDERO, A. ET AL., NAT BIOTECHNOL, vol. 31, 2013, pages 741 - 747
MELLOUGH, C.B. ET AL., STEM CELLS, vol. 33, 2015, pages 2416 - 2430
HALLAM, D. ET AL., STEM CELLS, 2018
REICHMAN, S. ET AL., PNAS, vol. 111, 2014, pages 8518 - 8523
DISTEFANO, T. ET AL., STEM CELL REPORTS, vol. 10, 2018, pages 300 - 313
TUCKER, B.A ET AL., STEM CELLS TRANSL MED, vol. 2, 2013, pages 16 - 24
WAHLIN, K.J. ET AL., SCI REP, vol. 7, 2017, pages 766
NATURE METHODS, vol. 8, 2011, pages 424 - 429
PROC. NATL. ACAD. SCI. USA., vol. 105, no. 36, 9 September 2008 (2008-09-09), pages 13409 - 14
NAT BIOTECHNOL, vol. 28, 2010, pages 611 - 615
NAT COMMUN, vol. 3, 2012, pages 1236
NAT BIOTECHNOL, vol. 19, 2001, pages 971 - 974
"PAGI method", 2006, article "a method for testing photographic gelatin"
SHIRAI ET AL., PNAS, vol. 113, pages E81 - E90
See also references of EP 4206321A4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Download PDF: