Title:
MEDIUM FOR TISSUE FOR TRANSPLANTATION
Document Type and Number:
WIPO Patent Application WO/2022/054924
Kind Code:
A1
Abstract:
A purpose of the present invention is to provide a medium suitable for subretinal transplantation of retinal tissue for treating of retinal degenerative disease such as retinitis pigmentosa, and a transplantation composition that contains retinal tissue and said medium. The medium for transplantation according to the present invention is for subretinal transplantation of retinal tissue, has a viscosity of 5-500 mPa•s when shear speed (1/s) is 2 at 25°C, and contains hyaluronic acid and a pharmaceutically acceptable aqueous liquid. The transplantation composition according to the present invention contains retinal tissue for transplantation and the medium for transplantation according to the present invention.
More Like This:
Inventors:
MANDAI MICHIKO (JP)
TAKAHASHI MASAYO (JP)
KAMEI TATSUYA (JP)
ONO KEIICHI (JP)
WATARI KENJI (JP)
KUWAHARA ATSUSHI (JP)
TAKAHASHI MASAYO (JP)
KAMEI TATSUYA (JP)
ONO KEIICHI (JP)
WATARI KENJI (JP)
KUWAHARA ATSUSHI (JP)
Application Number:
PCT/JP2021/033386
Publication Date:
March 17, 2022
Filing Date:
September 10, 2021
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
RIKEN (JP)
RIKEN (JP)
International Classes:
A61K9/08; A61K47/36; A61K35/30; A61K35/545; A61L27/20; A61L27/36; A61L27/40; A61P27/02; C12N5/0793
Domestic Patent References:
| WO2019050015A1 | 2019-03-14 | |||
| WO2019050015A1 | 2019-03-14 | |||
| WO1996022362A1 | 1996-07-25 | |||
| WO2002101057A1 | 2002-12-19 | |||
| WO2005012390A1 | 2005-02-10 | |||
| WO2009148170A1 | 2009-12-10 | |||
| WO2011055855A1 | 2011-05-12 | |||
| WO2013077425A1 | 2013-05-30 | |||
| WO2015025967A1 | 2015-02-26 | |||
| WO2016063985A1 | 2016-04-28 | |||
| WO2016063986A1 | 2016-04-28 | |||
| WO2017183732A1 | 2017-10-26 | |||
| WO2012173207A1 | 2012-12-20 | |||
| WO2015053375A1 | 2015-04-16 | |||
| WO2015053376A1 | 2015-04-16 | |||
| WO2015068505A1 | 2015-05-14 | |||
| WO2017043605A1 | 2017-03-16 | |||
| WO2019017492A1 | 2019-01-24 | |||
| WO2019054514A1 | 2019-03-21 | |||
| WO2019054515A1 | 2019-03-21 | |||
| WO1997021993A2 | 1997-06-19 | |||
| WO2004066929A2 | 2004-08-12 | |||
| WO2004093799A2 | 2004-11-04 | |||
| WO2000039077A2 | 2000-07-06 | |||
| WO2001098256A1 | 2001-12-27 | |||
| WO2003018515A2 | 2003-03-06 | |||
| WO2003084915A1 | 2003-10-16 | |||
| WO2002094319A1 | 2002-11-28 | |||
| WO2003064369A1 | 2003-08-07 | |||
| WO2007132475A1 | 2007-11-22 | |||
| WO2007009913A1 | 2007-01-25 | |||
| WO2003094845A2 | 2003-11-20 | |||
| WO2002051805A1 | 2002-07-04 | |||
| WO2010122980A1 | 2010-10-28 | |||
| WO2019017491A1 | 2019-01-24 |
Foreign References:
| JP2005517468A | 2005-06-16 | |||
| US5843780A | 1998-12-01 | |||
| US6200806B1 | 2001-03-13 | |||
| US6280718B1 | 2001-08-28 | |||
| JP2002053564A | 2002-02-19 | |||
| JP2002370978A | 2002-12-24 | |||
| JP2000256190A | 2000-09-19 |
Other References:
MITROUSIS NIKOLAOS; HACIBEKIROGLU SABIHA; HO MARGARET T.; SAUVé YVES; NAGY ANDRAS; VAN DER KOOY DEREK; SHOICHET MOLLY S.: "Hydrogel-mediated co-transplantation of retinal pigmented epithelium and photoreceptors restores vision in an animal model of advanced retinal degeneration", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 257, 30 July 2020 (2020-07-30), AMSTERDAM, NL , XP086253012, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2020.120233
TIAN YANGZI, RICHARD DAVIS, MICHAEL R ZONCA JR, JEFFREY H STERN, SALLY TEMPLE, YUBING XIE : "Screening and optimization of potential injection vehicles for storage of retinal pigment epithelial stem cell before transplantation", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, WILEY, US, vol. 13, no. 1, 31 January 2019 (2019-01-31), US , pages 76 - 86, XP055911599, ISSN: 1932-7005
HUMAYUN MARK S, DE JUAN, DEL CERRO MANUEL, DAGNELIE GISLIN, RADNER WOLFGANG, SADDA SRINIVAS R, CONSTANCIA DEL CERRO: "Human Neural Retinal Transplantation", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY, US, vol. 41, no. 10, 1 September 2000 (2000-09-01), US , pages 3100 - 3106, XP055911595, ISSN: 0146-0404
JUTHAPORN ASSAWACHANANONT, MICHIKO MANDAI, SATOSHI OKAMOTO, CHIKAKO YAMADA, MOTOTSUGU EIRAKU, SHIGENOBU YONEMURA, YOSHIKI SASAI, M: "Transplantation of Embryonic and Induced Pluripotent Stem Cell-Derived 3D Retinal Sheets into Retinal Degenerative Mice", STEM CELL REPORTS, CELL PRESS, UNITED STATES, vol. 2, no. 5, 1 May 2014 (2014-05-01), United States , pages 662 - 674, XP055617220, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2014.03.011
A. KUWAHARA ET AL.: "Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue", NATURE COMMUNICATIONS, vol. 6, 2015, XP055791403, DOI: 10.1038/ncomms7286
M. MANDAI ET AL.: "Autologous InducedStem-Cell-Derived Retinal Cells for Macular Degeneration", NEW ENGLAND JOURNAL OF MEDICINE, vol. 376, no. 11, 2017, pages 1038 - 1046, XP055782260, DOI: 10.1056/NEJMoa1608368
Y. TIAN ET AL.: "Screening and optimization of potential injection vehicles for storage of retinalpigment epithelial stem cell before transplantation", J TISSUE ENG REGEN MED, vol. 13, no. 1, 2019, pages 76 - 86, XP055911599
T. NAKAZAWA ET AL.: "Tumor Necrosis Factor-Mediates Photoreceptor Death in a Rodent Model of Retinal Detachment", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 52, no. 3, 2011, pages 1384 - 1391
BRYCE T. MCLELLAND ET AL., IOVS, vol. 59, no. 6, May 2018 (2018-05-01), pages 2586
NAKANO,T. ET AL., CELL STEM CELL, vol. 10, no. 6, 2012, pages 771 - 785
KAWAHARAA. ET AL., NATURE COMMUNICATIONS, vol. 6, 2015, pages 6286
KUWAHARAAYAMASAKI S ET AL., SCI REP, vol. 9, no. 1, 12 December 2019 (2019-12-12), pages 18936
LAMBA,D. AGUST, J.REH, T. A, CELL STEM CELL, vol. 4, 2009, pages 73 - 79
ZHU,J.CIFUENTES, HREYNOLDS, JLAMBA, D. A, CELL STEM CELL, vol. 20, no. 374-384, 2017, pages e375
MEYER,J. S. ET AL., STEM CELLS, vol. 29, 2011, pages 1206 - 1218
ZHONG,X. ET AL.: "5", NAT COMMUN, 2014
BOUCHERIE,C ET AL., STEM CELLS, vol. 31, 2013, pages 458 - 466
GONZALEZ-CORDERO,A. ET AL., NAT BIOTECHNOL, vol. 31, 2013, pages 741 - 747
MELLOUGH,C. B. ET AL., STEM CELLS, vol. 33, 2015, pages 2416 - 2430
HALLAM,D. ET AL., STEM CELLS, 2018
REICHMAN,S. ET AL., PNAS, vol. 111, 2014, pages 8518 - 8523
GAGLIARDI,G. ET AL.: "11", STEM CELL REPORTS, vol. 10, 2018, pages 665 - 680
TUCKER,B. A. ET AL., STEM CELLS TRANSL MED, vol. 2, 2013, pages 16 - 24
WAHLIN,K. J. ET AL., SCI REP, vol. 7, 2017, pages 766
YAMANAKA ET AL., CELL, vol. 126, no. 4, 2006, pages 663 - 676
CELL, vol. 131, no. 5, 2007, pages 861 - 872
SCIENCE, vol. 318, no. 5858, 2007, pages 1917 - 1920
NAT. BIOTECHNOL., vol. 26, no. 1, 2008, pages 101 - 106
"341", SCIENCE, 2013, pages 651 - 654
PLOS ONE, vol. 5, no. 1, 20 January 2010 (2010-01-20), pages e8763
STEM CELLS, vol. 29, no. 8, August 2011 (2011-08-01), pages 1206 - 18
PROC NATL ACAD SCI USA., vol. 111, no. 23, 10 June 2014 (2014-06-10), pages 8518 - 23
NAT COMMUN., vol. 5, 10 June 2014 (2014-06-10), pages 4047
STEM CELL REPORTS, vol. 2, no. 2, 2014, pages 205 - 218
ZHONG,X. ET AL., NAT COMMUN, vol. 5, 2014
NATURE METHODS, vol. 8, 2011, pages 424 - 429
PROC. NATL. ACAD. SCI. USA., vol. 105, no. 36, 9 September 2008 (2008-09-09), pages 13409 - 14
NAT BIOTECHNOL, vol. 28, 2010, pages 611 - 615
NAT COMMUN, vol. 3, 2012, pages 1236
NAT BIOTECHNOL, vol. 19, 2001, pages 971 - 974
SHIRAI ET AL., PROC NATL ACAD SCI U S A, vol. 113, 2016, pages E81 - 90
SHIRAI ET AL., PNAS, vol. 113, pages E81 - E90
TIAN YANGZI, RICHARD DAVIS, MICHAEL R ZONCA JR, JEFFREY H STERN, SALLY TEMPLE, YUBING XIE : "Screening and optimization of potential injection vehicles for storage of retinal pigment epithelial stem cell before transplantation", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, WILEY, US, vol. 13, no. 1, 31 January 2019 (2019-01-31), US , pages 76 - 86, XP055911599, ISSN: 1932-7005
HUMAYUN MARK S, DE JUAN, DEL CERRO MANUEL, DAGNELIE GISLIN, RADNER WOLFGANG, SADDA SRINIVAS R, CONSTANCIA DEL CERRO: "Human Neural Retinal Transplantation", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY, US, vol. 41, no. 10, 1 September 2000 (2000-09-01), US , pages 3100 - 3106, XP055911595, ISSN: 0146-0404
JUTHAPORN ASSAWACHANANONT, MICHIKO MANDAI, SATOSHI OKAMOTO, CHIKAKO YAMADA, MOTOTSUGU EIRAKU, SHIGENOBU YONEMURA, YOSHIKI SASAI, M: "Transplantation of Embryonic and Induced Pluripotent Stem Cell-Derived 3D Retinal Sheets into Retinal Degenerative Mice", STEM CELL REPORTS, CELL PRESS, UNITED STATES, vol. 2, no. 5, 1 May 2014 (2014-05-01), United States , pages 662 - 674, XP055617220, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2014.03.011
A. KUWAHARA ET AL.: "Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue", NATURE COMMUNICATIONS, vol. 6, 2015, XP055791403, DOI: 10.1038/ncomms7286
M. MANDAI ET AL.: "Autologous InducedStem-Cell-Derived Retinal Cells for Macular Degeneration", NEW ENGLAND JOURNAL OF MEDICINE, vol. 376, no. 11, 2017, pages 1038 - 1046, XP055782260, DOI: 10.1056/NEJMoa1608368
Y. TIAN ET AL.: "Screening and optimization of potential injection vehicles for storage of retinalpigment epithelial stem cell before transplantation", J TISSUE ENG REGEN MED, vol. 13, no. 1, 2019, pages 76 - 86, XP055911599
T. NAKAZAWA ET AL.: "Tumor Necrosis Factor-Mediates Photoreceptor Death in a Rodent Model of Retinal Detachment", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 52, no. 3, 2011, pages 1384 - 1391
BRYCE T. MCLELLAND ET AL., IOVS, vol. 59, no. 6, May 2018 (2018-05-01), pages 2586
NAKANO,T. ET AL., CELL STEM CELL, vol. 10, no. 6, 2012, pages 771 - 785
KAWAHARAA. ET AL., NATURE COMMUNICATIONS, vol. 6, 2015, pages 6286
KUWAHARAAYAMASAKI S ET AL., SCI REP, vol. 9, no. 1, 12 December 2019 (2019-12-12), pages 18936
LAMBA,D. AGUST, J.REH, T. A, CELL STEM CELL, vol. 4, 2009, pages 73 - 79
ZHU,J.CIFUENTES, HREYNOLDS, JLAMBA, D. A, CELL STEM CELL, vol. 20, no. 374-384, 2017, pages e375
MEYER,J. S. ET AL., STEM CELLS, vol. 29, 2011, pages 1206 - 1218
ZHONG,X. ET AL.: "5", NAT COMMUN, 2014
BOUCHERIE,C ET AL., STEM CELLS, vol. 31, 2013, pages 458 - 466
GONZALEZ-CORDERO,A. ET AL., NAT BIOTECHNOL, vol. 31, 2013, pages 741 - 747
MELLOUGH,C. B. ET AL., STEM CELLS, vol. 33, 2015, pages 2416 - 2430
HALLAM,D. ET AL., STEM CELLS, 2018
REICHMAN,S. ET AL., PNAS, vol. 111, 2014, pages 8518 - 8523
GAGLIARDI,G. ET AL.: "11", STEM CELL REPORTS, vol. 10, 2018, pages 665 - 680
TUCKER,B. A. ET AL., STEM CELLS TRANSL MED, vol. 2, 2013, pages 16 - 24
WAHLIN,K. J. ET AL., SCI REP, vol. 7, 2017, pages 766
YAMANAKA ET AL., CELL, vol. 126, no. 4, 2006, pages 663 - 676
CELL, vol. 131, no. 5, 2007, pages 861 - 872
SCIENCE, vol. 318, no. 5858, 2007, pages 1917 - 1920
NAT. BIOTECHNOL., vol. 26, no. 1, 2008, pages 101 - 106
"341", SCIENCE, 2013, pages 651 - 654
PLOS ONE, vol. 5, no. 1, 20 January 2010 (2010-01-20), pages e8763
STEM CELLS, vol. 29, no. 8, August 2011 (2011-08-01), pages 1206 - 18
PROC NATL ACAD SCI USA., vol. 111, no. 23, 10 June 2014 (2014-06-10), pages 8518 - 23
NAT COMMUN., vol. 5, 10 June 2014 (2014-06-10), pages 4047
STEM CELL REPORTS, vol. 2, no. 2, 2014, pages 205 - 218
ZHONG,X. ET AL., NAT COMMUN, vol. 5, 2014
NATURE METHODS, vol. 8, 2011, pages 424 - 429
PROC. NATL. ACAD. SCI. USA., vol. 105, no. 36, 9 September 2008 (2008-09-09), pages 13409 - 14
NAT BIOTECHNOL, vol. 28, 2010, pages 611 - 615
NAT COMMUN, vol. 3, 2012, pages 1236
NAT BIOTECHNOL, vol. 19, 2001, pages 971 - 974
SHIRAI ET AL., PROC NATL ACAD SCI U S A, vol. 113, 2016, pages E81 - 90
SHIRAI ET AL., PNAS, vol. 113, pages E81 - E90
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Download PDF: